743935e9b9c947fec7a0eb3536af34a8 pmc_10102678.pdf c92954103af20dd9fef0be09a980b9880024bd97 pmc_10102678.pdf 589dbfd731a7b362dba6c6d1584ea66f401ac23dd88cab6875841e0050649926 pmc_10102678.pdf Title: Safety and immunogenicity of the protein-based PHH-1V compared to BNT162b2 as a heterologous SARS-CoV-2 booster vaccine in adults vaccinated against COVID-19: a multicentre, randomised, double-blind, non-inferiority phase IIb trial Subject: The Lancet Regional Health - Europe, 28 (2023) 100613. doi:10.1016/j.lanepe.2023.100613 Author: Júlia Corominas Creator: Elsevier Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Tue Apr 25 13:07:33 2023 CEST ModDate: Tue Apr 25 13:08:18 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1321698 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FFIIDE+AdvOT20212610.B Type 1C WinAnsi yes yes no 958 0 FFIIDF+AdvOT2867105d.I Type 1C WinAnsi yes yes no 960 0 FFIIGF+AdvstixtSym Type 1C Custom yes yes yes 970 0 FFIIGG+AdvOT3f9da5b7 Type 1C WinAnsi yes yes no 972 0 FFIIHG+AdvOT3f9da5b7+20 Type 1C WinAnsi yes yes no 965 0 FFIIHH+AdvOT3f9da5b7+fb Type 1C Custom yes yes yes 982 0 FFIIHI+AdvTTae869a4c Type 1C WinAnsi yes yes no 984 0 FFIIHJ+AdvTTac2dc932 Type 1C WinAnsi yes yes no 986 0 FFIIHK+AdvTTae869a4c+fb Type 1C Custom yes yes yes 976 0 FFIILM+AdvTT0d8bc80f.B+20 Type 1C WinAnsi yes yes no 483 0 FFIILN+AdvOTe3b1fbf3.B+22 Type 1C Custom yes yes yes 484 0 FFIILO+AdvOTe3b1fbf3.B+03 Type 1C Custom yes yes yes 485 0 FFIIMP+AdvTTae869a4c+20 Type 1C WinAnsi yes yes no 488 0 FFIILK+AdvTT0d8bc80f.B Type 1C WinAnsi yes yes no 493 0 FFIILL+AdvTT0d8bc80f.B+fb Type 1C Custom yes yes yes 475 0 FFIINA+AdvTTae869a4c+22 Type 1C Custom yes yes no 500 0 FFIIOA+AdvOTb0c9bf5d+03 Type 1C Custom yes yes yes 504 0 FFIJCP+ArialMT Type 1C Custom yes yes no 523 0 FFIJDA+AdvTTb4077e6a Type 1C WinAnsi yes yes no 519 0 FFIJDB+AdvOT2867105d.I+fb Type 1C Custom yes yes yes 520 0 FFIJDC+AdvOT2867105d.I+20 Type 1C WinAnsi yes yes no 526 0 FFIJED+AdvOT20212610.B+fb Type 1C Custom yes yes yes 536 0 FFIJEE+AdvOT3f9da5b7+22 Type 1C Custom yes yes no 533 0 FFIJFF+AdvOT20212610.B+20 Type 1C WinAnsi yes yes no 543 0 FFIJHF+Arial-BoldMT Type 1C WinAnsi yes yes no 549 0 FFIJHG+Helvetica Type 1C WinAnsi yes yes no 552 0 FFIKNO+Verdana Type 1C WinAnsi yes yes no 555 0 FFIKNP+Verdana-Bold Type 1C WinAnsi yes yes no 556 0 FFILBP+Symbol Type 1C Custom yes yes yes 566 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-08-31 02:28:56 CEST RepresentationInformation: pmc_10102678.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-27 02:24:35 CEST Size: 1321698 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'appsec1' cannot be found Offset: 1286280 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 1286280 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 1286280 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl1fna' cannot be found Offset: 1286280 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 1286280 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 1286280 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'bib37' cannot be found Offset: 1286280 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib37' cannot be found Offset: 1286280 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1092 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Safety and immunogenicity of the protein-based PHH-1V compared to BNT162b2 as a heterologous SARS-CoV-2 booster vaccine in ..⸩㸾൥湤潢樍㄰㜴‰扪഼㰯偡牥湴‱〷㌠〠刯乥硴‱〸㌠〠刯䑥獴⣾＀昀氀椀渀欀ㄩ⽔楴汥⣾＀䤀渀琀爀漀搀甀挀琀椀漀温㸾൥湤潢樍㄰㜵‰扪഼㰯偡牥湴‱〷㌠〠刯䑥獴⣾＀戀氀椀渀欀㔩⽐牥瘠㄰㜶‰⁒⽔楴汥⣾＀刀攀昀攀爀攀渀挀攀猩㸾൥湤潢樍㄰㜶‰扪഼㰯偡牥湴‱〷㌠〠刯乥硴‱〷㔠〠刯䑥獴⣾＀昀氀椀渀欀㔩⽐牥瘠㄰㜷‰⁒⽔楴汥⣾＀䄀瀀瀀攀渀搀椀砀 䄀⸀ 匀甀瀀瀀氀攀洀攀渀琀愀爀礀 搀愀琀愩㸾൥湤潢樍㄰㜷‰扪഼㰯偡牥湴‱〷㌠〠刯乥硴‱〷㘠〠刯䑥獴⣾＀戀氀椀渀欀㐩⽐牥瘠㄰㜸‰⁒⽔楴汥⣾＀䄀挀欀渀漀眀氀攀搀最攀洀攀渀琀猩㸾൥湤潢樍㄰㜸‰扪഼㰯偡牥湴‱〷㌠〠刯乥硴‱〷㜠〠刯䑥獴⣾＀戀氀椀渀欀㌩⽐牥瘠㄰㜹‰⁒⽔楴汥⣾＀䐀攀挀氀愀爀愀琀椀漀渀 漀昀 椀渀琀攀爀攀猀琀猩㸾൥湤潢樍㄰㜹‰扪഼㰯偡牥湴‱〷㌠〠刯乥硴‱〷㠠〠刯䑥獴⣾＀戀氀椀渀欀㈩⽐牥瘠㄰㠰‰⁒⽔楴汥⣾＀䐀愀琀愀 猀栀愀爀椀渀最 猀琀愀琀攀洀攀渀琀䄀氀氀 搀愀琀愀 爀攀氀攀瘀愀渀琀 琀漀 琀栀攀 猀琀甀搀礀 愀爀攀 椀渀挀氀甀搀攀搀 椀渀 琀栀攀 愀爀琀椀挀氀攀 漀爀 甀瀀氀漀愀搀攀搀 愀猀 猀甀瀀瀀氀攀洀攀渀琀愀爀礀 椀渀昀漀爀洀愀琀椀漀渀⸀  ⸀⸀ Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Study design and participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Randomisation and masking Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Study vaccine Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Procedures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Role of the funding source Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Data sharing statementAll data relevant to the study are included in the article or uploaded as supplementary information. ..⸩㸾൥湤潢樍㄰㠰‰扪഼㰯偡牥湴‱〷㌠〠刯乥硴‱〷㤠〠刯䑥獴⣾＀戀氀椀渀欀ㄩ⽐牥瘠㄰㠱‰⁒⽔楴汥⣾＀䌀漀渀琀爀椀戀甀琀漀爀猀嘀攀爀椀猀琀愀琀 眀愀猀 爀攀猀瀀漀渀猀椀戀氀攀 昀漀爀 洀愀渀愀最椀渀最 琀栀攀 搀愀琀愀⸀ 䄀甀琀栀漀爀猀 挀漀渀琀爀椀戀甀琀攀搀 琀漀 琀栀攀 愀挀焀甀椀猀椀琀椀漀渀Ⰰ 愀渀愀氀礀猀椀猀Ⰰ 愀渀搀⼀漀爀 椀渀琀攀爀瀀 ⸀⸀ Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Declaration of interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Appendix A. Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Info: Title: Safety and immunogenicity of the protein-based PHH-1V compared to BNT162b2 as a heterologous SARS-CoV-2 booster vaccine in adults vaccinated against COVID-19: a multicentre, randomised, double-blind, non-inferiority phase IIb trial Author: Júlia Corominas Subject: The Lancet Regional Health - Europe, 28 (2023) 100613. doi:10.1016/j.lanepe.2023.100613 Creator: Elsevier Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Tue Apr 25 13:37:33 CEST 2023 ModDate: Tue Apr 25 13:38:18 CEST 2023 ID: 0x1dc7beb17d5999157cfdeace6e9e1cc9, 0x5e038f5fd1f8e344bb2160d4dd4447cc Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 127 ImageHeight: 580 ColorSpace: CMYK BitsPerSample: 8 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-52, -239, 833, 833 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.lanepe.2023.100613 Safety and immunogenicity of the protein-based PHH-1V compared to BNT162b2 as a heterologous SARS-CoV-2 booster vaccine in adults vaccinated against COVID-19: a multicentre, randomised, double-blind, non-inferiority phase IIb trial Júlia Corominas Carme Garriga Antoni Prenafeta Alexandra Moros Manuel Cañete Antonio Barreiro Luis González-González Laia Madrenas Irina Güell Bonaventura Clotet Nuria Izquierdo-Useros Dàlia Raïch-Regué Marçal Gallemí Julià Blanco Edwards Pradenas Benjamin Trinité Julia G. Prado Oscar Blanch-Lombarte Raúl Pérez-Caballero Montserrat Plana Ignasi Esteban Carmen Pastor-Quiñones Xavier Núñez-Costa Rachel Abu Taleb Paula McSkimming Alex Soriano Jocelyn Nava Jesse Omar Anagua Rafel Ramos Ruth Martí Lluch Aida Corpes Comes Susana Otero Romero Xavier Martinez Gomez Carla Sans-Pola José Moltó Susana Benet Lucía Bailón Jose R. Arribas Alberto M. Borobia Javier Queiruga Parada Jorge Navarro-Pérez Maria José Forner Giner Rafael Ortí Lucas María del Mar Vázquez Jiménez Salvador Oña Compán Melchor Alvarez-Mon Daniel Troncoso Eunate Arana-Arri Susana Meijide Natale Imaz-Ayo Patricia Muñoz García Sofía de la Villa Martínez Sara Rodríguez Fernández Teresa Prat Èlia Torroella Laura Ferrer SARS-CoV-2 Protein-based vaccine Heterologous boost SARS-CoV-2 variants Neutralizing antibodies The Lancet Regional Health - Europe, 28 (2023) 100613. doi:10.1016/j.lanepe.2023.100613 The Author(s) journal The Lancet Regional Health - Europe © 2023 The Author(s). Published by Elsevier Ltd. 2666-7762 28 May 2023 100613 100613 10.1016/j.lanepe.2023.100613 https://doi.org/10.1016/j.lanepe.2023.100613 2010-04-23 true 10.1016/j.lanepe.2023.100613 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.lanepe.2023.100613 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2023-04-25T16:37:33+05:30 2023-04-25T16:38:18+05:30 2023-04-25T16:38:18+05:30 True Acrobat Distiller 8.0.0 (Windows) uuid:82fc49ba-0502-412c-8146-a09af119112f uuid:a422c8b2-0f2b-4ccc-8b1d-4961cc460139 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 85, 566, 85, 568 Annotation: Subtype: Link Rect: 87, 567, 90, 573 Destination: 771 Annotation: Subtype: Link Rect: 91, 567, 97, 573 Destination: 771 Annotation: Subtype: Link Rect: 142, 566, 142, 568 Annotation: Subtype: Link Rect: 143, 567, 146, 573 Destination: 771 Annotation: Subtype: Link Rect: 147, 567, 153, 573 Destination: 771 Annotation: Subtype: Link Rect: 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