303e4e8ce307476607874dfc2ebb2b6e pmc_10104169.pdf 5db74750600f0ddf9a85f8c473c758df36f05be6 pmc_10104169.pdf 81bc5a8ec3fd492fbec1e950127de6ce172735c4e1e631c14d49832deeae3031 pmc_10104169.pdf Title: Neural substrates of cognitive impairment in a NMDAR hypofunction mouse model of schizophrenia and partial rescue by risperidone Subject: N-methyl D-aspartate receptor (NMDAR) hypofunction is a pathophysiological mechanism relevant for schizophrenia. Keywords: phencyclidine, atypical antipsychotic drugs, theta and gamma oscillations, neural synchrony, novel object recognition, auditory evoked potentials, prefrontal cortex, hippocampus Author: Cristina Delgado-Sallent Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Mon Mar 27 12:09:42 2023 CEST ModDate: Mon Mar 27 13:19:24 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 5660064 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- TWKGQU+MinionPro-Regular Type 1 Custom yes yes no 27 0 SYFAYB+MuseoSans-700 Type 1 Custom yes yes no 28 0 SBQCTN+MuseoSans-300 Type 1 Custom yes yes no 29 0 YMHZHH+MuseoSans-300Italic Type 1 Custom yes yes no 34 0 OVESSF+MuseoSans-500 Type 1 Custom yes yes no 35 0 MLYTRF+MTSYN Type 1 Builtin yes yes no 36 0 OLELCW+MinionPro-It Type 1 Custom yes yes no 103 0 JYDOCF+MTGU Type 1 Builtin yes yes no 113 0 UZFHLO+RBLMI Type 1 Builtin yes yes no 114 0 QFWRXY+MinionPro-Bold Type 1 Custom yes yes no 115 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-08-11 02:27:26 CEST RepresentationInformation: pmc_10104169.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-08-01 02:37:43 CEST Size: 5660064 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 921 FreeObjects: 6 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Neural substrates of cognitive impairment in a NMDAR hypofunction mouse model of schizophrenia and partial rescue by risperidone Children: Item: Title: Introduction Item: Title: Materials and methods Children: Item: Title: Animals Item: Title: Surgeries Item: Title: Behavioral tests Children: Item: Title: Resting states Item: Title: Novel object recognition test (NOR) Item: Title: Auditory evoked potential (AEP) and mismatch negativity (MMN) tests Item: Title: Subchronic PCP model and pharmacology Item: Title: Neurophysiological recordings and data analyses Children: Item: Title: Oscillatory activity Item: Title: Spiking activity Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: Chronic risperidone prevented sPCP-induced short-term and long-term memory deficits Item: Title: Risperidone partially rescued sPCP-induced disruptions of theta and gamma synchronization in prefrontal-hippocampal circuits during quiet alertness Item: Title: Risperidone partially restored the neural correlates of sPCP-induced poor recognition memory in prefrontal-hippocampal circuits Item: Title: Risperidone improved the neurophysiological signatures of auditory processing in sPCP-treated mice but did not reinstate MMN Item: Title: Discussion Item: Title: Data availability statement Item: Title: Ethics statement Item: Title: Author contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: Conflict of interest Item: Title: Publisher's note Item: Title: Supplementary material Item: Title: References Info: Title: Neural substrates of cognitive impairment in a NMDAR hypofunction mouse model of schizophrenia and partial rescue by risperidone Author: Cristina Delgado-Sallent Subject: N-methyl D-aspartate receptor (NMDAR) hypofunction is a pathophysiological mechanism relevant for schizophrenia. 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Cristina Delgado-Sallent Thomas Gener Pau Nebot Cristina López-Cabezón M. 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