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Item: Title: Results Children: Item: Title: Cumulative incidence of VA-LRTI by pandemic waves and by geographic region. Item: Title: Microbiology. Item: Title: VA-LRTI clinical characteristics and outcomes. Item: Title: Impact of VA-LRTI on hospital mortality. Item: Title: Risk factors associated with the development of VA-LRTI. Item: Title: Ethics approval and consent to participate. 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977 FontFile2: true XMP: 2023-04-19T18:25:53+05:30 Springer 2023-04-21T12:00:20+02:00 2023-04-21T12:00:20+02:00 application/pdf https://doi.org/10.1038/s41598-023-32265-5 Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-023-32265-5 Risk factors for developing ventilator-associated lower respiratory tract infection in patients with severe COVID-19: a multinational, multicentre study, prospective, observational study Luis Felipe Reyes Alejandro Rodriguez Yuli V. Fuentes Sara Duque Esteban García-Gallo Alirio Bastidas Cristian C. Serrano-Mayorga Elsa D. Ibáñez-Prada Gerard Moreno Paula C. Ramirez-Valbuena Gustavo Ospina-Tascon Glenn Hernandez Edwin Silva Ana Maria Díaz Manuel Jibaja Magdalena Vera-Alarcon Emili Díaz María Bodí Jordi Solé-Violán Ricard Ferrer Antonio Albaya-Moreno Lorenzo Socias William Figueroa Jose L. Lozano-Villanueva Fabio Varón-Vega Ángel Estella Ana Loza-Vazquez Ruth Jorge-García Isabel Sancho Manu Shankar-Hari Ignacio Martin-Loeches Luis Antonio Gorordo Ricardo Buitrago Marcela Poveda Lina Maria Saucedo Elisa Estenssoro Guillermo Ortiz Nicolas Nin Alfonso Jose Arango Alvaro Aguilar Andrea Lizeth Ayala Andrea Viviana Bayona Andrea Lizeth Ayala Angelica Rodriguez Carol Viviana Aponte Carolina Forero-Carreño Conny Stefanny Muñoz Cristian Augusto Estrada Cristopher Romero Danilo Trujillo Diego Holguin Jesus Chavez-Villegas Faure Rodriguez Francisco Franco Hernan Sánchez Janett Vanessa Moncayo Jennifer A. Pinedo Jesica Valeria Bravo Jose David Cruz Jose Miguel Angel Jovany Castro-Lara Karen Andrea Mantilla Lorena Garcia Lorena Pabón Luis Arturo Lopez Luis Fernando Mamani Marisa Lucrecia Yupa Valeria Catalina Quevedo Ana Loza Diego Matallana Zapata Isabel Díaz Torres Sonia Ibañez Cuadros María Recuerda Nuñez Maria Luz Carmona Pérez Jorge Gómez Ramos Alba Villares Casas María Luisa Cantón José Javier González Contreras Helena Pérez Chomón Nerissa Alvarez Chicote Alberto Sousa González María De Alba Aparicio Ruth Jorge García Laura Sánchez Montori Sandra Herrero García Paula Abanses Moreno Carlos Mayordomo García Tomás Mallor Bonet Paula Omedas Bonafonte Enric Franquesa Gonzalez Nestor Bueno Vidales Paula Ocabo Buil Carlos Serón Arbeloa Isabel Sancho Pablo Guerrero Ibañez Pablo Gutierrez María Concepción Valdovinos Raquel Canto Ruth Jorge García Laura Sánchez Montori Sandra Herrero García Paula Abanses Moreno Carlos Mayordomo García Tomás Mallor Bonet Paula Omedas Bonafonte Enric Franquesa Gonzalez Nestor Bueno Vidales Paula Ocabo Buil Carlos Serón Arbeloa Isabel Sancho Pablo Guerrero Ibañez Pablo Gutierrez María Concepción Valdovinos Raquel Canto Ana Luz Balán Mariño María José Gutiérrez Fernández Marta Martín Cuadrado Belén García Arias Lorena Forcelledo Espina Lucía Viña Soria Lorena Martín Iglesias Lucía López Amor Elisabet Fernández Rey Emilio García Prieto Débora Fernández Ruíz Carla Martínez González Lorenzo Socias Marcio Borges‐Sá María Aranda Pérez Antonia Socias José Ma Bonell Goytisolo Inmaculada Alcalde Mayayo Carlos Corradini Isabel Ceniceros Edwin Rodríguez Jose Ignacio Ayestarán Rota Mariana Andrea Novo Joaquim Colomina Climent Albert Figueras Castilla Tomàs Leal Rullan Maria Magdalena Garcias Sastre Rossana Pérez Senoff Ramón Fernández Juan Carlos Martín González Carmen Pérez Ortiz José Luciano Cabrera Santana Juan José Cáceres Agra Domingo González Romero Ana Casamitjana Ortega Luis Alberto Ramos Gómez Carolina Montelongo Ojeda Jordi Solé-Violán Alejandro Rodríguez María Bodí Gerard Moreno Sandra Trefler Laura Claverias Raquel Carbonell Erika Esteve Montserrat Olona Xavier Teixidó Monserrat Vallverdú Vidal Begoña Balsera Garrido Elisabeth Papiol Gallofré Raquel Albertos Martell Rosa Alcaráz Peñarrocha Xavier Nuvials Casals Ricard Ferrer Roca Eric Adrián Mayor Vázquez Ferrán Roche Campo Pablo Concha Martínez Diego Franch Llasat Joan Ramón Masclanz Judith Marín‐ Corral Purificación Pérez Rosana Muñoz Clara Vila Francisco Javier González de Molina Elisabeth Navas Moya Josep Trenado Imma Vallverdú Eric Castañé Emili Díaz Santos Gemma Goma Gemma Edg Borja Suberviola Antonio Albaya Moreno Carlos Marian Crespo Carmen Carolina Sena Pérez Francisca Arbol Linde Diana Monge Donaire Vega Losada Martínez Nuria Rodrigo Castroviejo Gerardo Ferrigno Reyes Beltrán Carolina Sanmartino Concepción Tarancón Maján Alfredo Marcos Gutiérrez Virginia Hidalgo Valverde Caridad Martín López Oihane Badallo María del Valle Ortiz Rebeca Vara Arlanzón David Iglesias Posadilla María Teresa Recio Juan Carlos Ballesteros Enrique Laza Elena Gallego Curto Ma Car‐men Sánchez García Miguel Díaz‐Tavora Rosa Mancha Ana Ortega Montes Isabel Gallego Barbachano Eva Sanmartín Mantiñán María Lourdes Cordero Raquel María Rodríguez García Jorge Gámez Zapata María Gestal Vázquez María José Castro Orjales María Isabel Álvarez Diéguez Carmen Rivero Velasco Beatriz Lence Massa María Gestal Vázquez Ignacio Martí Diego Matallana Zapata Alberto Hernández Tejedor Esther Ma López Ramos Laura Alcázar Sánchez Elvira Rocío Molina Montero Ma Consuelo Pintado Delgado María Trascasa Muñoz de la Peña Yaiza Betania Ortiz de Zárate Ansotegui Alejandra Acha Aranda Juan Higuera Lucas Juan Antonio Sanchez Giralt Marta Chicot Llano Nuria Arevalillo Fernández Marta Sánchez Galindo Ricardo Andino Ruiz Alfonso Canabal Berlanga Miguel Sánchez Mercedes Nieto Eduardo Arias Sarmiento Adoración Bueno Blázquez Rosa María de la Casa Fátima Martín Samuel González Elena Martínez Quintana Bernardo Gil Rueda Áurea Higon Cañigral Laura López Gómez Pablo Safwat Bayoumi Delis Augusto Montenegro Muore Ángel Andrés Agamez Luengas Enriqueta Andreu Soler Ana Beatriz Pérez José Higinio de Gea García Rubén Jara Rubio Silvia Sánchez Cámara Alba Moreno Flores José Moya Sánchez Daniel Fran‐cisco Pérez Martínez Ma Desamparados del Rey Carrión María José Rico Lledó Juana María Serrano Navarro Juan Fran‐cisco Martín Ruíz Julián Triviño Hidalgo África López Ferrer Isabel Cremades Navalón Josefa Murcia Payá J. 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Allegre Gallego María del Carmen Lorente Ruth González Natera Raquel Garrido López de Murillo Tania Ojuel Gros Raquel Flecha Viguera Isabel López González Adriana García Herrera Loreto Vidaur Tello Maialen Aseguinolaza Itziar Eguibar Asunción Marqués Parra Sergio García Marti Alberto Lorenzo Aguilar Laura Bellver Bosch Victor Gascón Sanchez Sonia De la Guía Ortega Martín Parejo Montell Alberto Belenguer Muncharaz Hector Hernández Garces Victor Ramírez Montero Mónica Crespo Gómez Verónica Martí Algarra Susana Sancho Chinesta Joaquin Arguedas Cervera Faustino Álvarez Cebrian Begoña Balerdi Pérez Rosa Jannone Fores Javier Botella de Maglia Nieves Carbonell Monleón Jose Ferreres Franco Ainhoa Serrano Lazaro Mar Juan Díaz María Luisa Blasco Cortés Laura Fayos Julia Giménez Gaspar Soriano Ricardo Navarro Sonia Mas Elena Bisbal Laura Albert Johncard Romero Juan Fernández Cabreara Andrea Ortíz Antonio Margarit Ribas Neus Guasch 10.1038/s41598-023-32265-5 2010-04-23 true springer.com springerlink.com https://doi.org/10.1038/s41598-023-32265-5 10.1038/s41598-023-32265-5 2045-2322 journal Scientific Reports The Author(s) 2010-04-23 true 10.1038/s41598-023-32265-5 noindex springer.com springerlink.com VoR uuid:5f63a634-fe59-433d-be1b-3266a324aabc uuid:1c2dcaa6-763b-4ff9-9b5a-79fcbc312c02 default 1 converted uuid:152279ea-303d-4e7b-a5ba-5dca1cffa8fc converted to PDF/A-2b pdfToolbox 2023-04-19T18:27:26+05:30 converted uuid:d5b6f066-a2cf-403e-bac4-9c7ac3f522da converted to PDF/A-2b pdfToolbox 2023-04-19T18:28:11+05:30 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. 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Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 12 Thumb: true Page: Sequence: 13 Thumb: true Page: Sequence: 14 Thumb: true Page: Sequence: 15 Thumb: true Checksum: 6dddc57e Type: CRC32 Checksum: 5629dba48ee7c28886f11d613433c223 Type: MD5 Checksum: d6a6487f814cde500e551d45b77d47577ca89acc Type: SHA-1