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PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 492 FreeObjects: 3 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Overexpressing high levels of human vaspin limits high fat diet-induced obesity and enhances energy expenditure in a transgenic mouse Destination: bmark_351558823 Children: Item: Title: Introduction Destination: s1 Item: Title: Materials and methods Destination: s2 Children: Item: Title: Generation of vaspin-transgenic mice (h-vaspinTG) Destination: s2_1 Item: Title: Animals Destination: s2_2 Item: Title: Phenotypic characterization of h-vaspinTG mice Destination: s2_3 Item: Title: Gene expression analysis Destination: s2_4 Item: Title: Ex vivo glucose uptake into isolated skeletal muscle and mature adipocytes Destination: s2_5 Item: Title: Statistical analysis Destination: s2_6 Item: Title: Results Destination: s3 Children: Item: Title: Vaspin transgenic mice present highly supraphysiological levels of circulating vaspin Destination: s3_1 Item: Title: Vaspin transgenic mice are less sensitive to diet-induced obesity Destination: s3_2 Item: Title: Vaspin transgenic mice exhibit less adipocyte hypertrophy and ectopic lipid deposition in liver Destination: s3_3 Item: Title: Vaspin transgenic mice show improved metabolic profile after HFD Destination: s3_4 Item: Title: Discussion Destination: s4 Item: Title: Data availability statement Destination: s5 Item: Title: Ethics statement Destination: s6 Item: Title: Author contributions Destination: s7 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: References Destination: bmark_2090415954 Info: Keywords: serpin, metabolic disease, obesity, adipose tissue, mouse model, inflammation ID: 0xf81f3ac4e187a2a10cda969f8210a4a4, 0x7e279fc9abf42c408f13c5f4300b9749 Filters: FilterPipeline: FlateDecode 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-187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DGENHC+AdvTT749c1f5a.I FontSubset: true FirstChar: 69 LastChar: 120 FontDescriptor: FontName: DGENHC+AdvTT749c1f5a.I Flags: Nonsymbolic FontBBox: -145, -208, 989, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DGENGB+AdvOTd877c31c FontSubset: true FirstChar: 174 LastChar: 174 FontDescriptor: FontName: DGENGB+AdvOTd877c31c Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding XMP: Inka Rapöhn Ivet Elias Juliane Weiner Anna Pujol Stephanie Kehr Alexandra Chadt Hadi Al-Hasani Ralph Burkhardt Nora Klöting Michael Stumvoll Fatima Bosch Peter Kovacs John T. Heiker Jana Breitfeld Rapöhn I, Elias I, Weiner J, Pujol A, Kehr S, Chadt A, Al-Hasani H, Burkhardt R, Klöting N, Stumvoll M, Bosch F, Kovacs P, Heiker JT and Breitfeld J (2023) Overexpressing high levels of human vaspin limits high fat diet-induced obesity and enhances energy expenditure in a transgenic mouse. Front. Endocrinol. 14:1146454 Copyright © 2023 Rapöhn, Elias, Weiner, Pujol, Kehr, Chadt, Al-Hasani, Burkhardt, Klöting, Stumvoll, Bosch, Kovacs, Heiker and Breitfeld. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. 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