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Neurosci. 17:1143319. doi: 10.3389/fncel.2023.1143319 Keywords: Reelin, striatum, interneurons, dopamine projections, schizophrenia, Tourette's syndrome Author: Mònica Pardo Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Thu Apr 13 17:07:38 2023 CEST ModDate: Thu Apr 13 17:24:33 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 6234171 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FLQFJB+MinionPro-Regular Type 1 Custom yes yes no 27 0 QZNZQI+MuseoSans-700 Type 1 Custom yes yes no 28 0 NUQBNP+MuseoSans-300 Type 1 Custom yes yes no 29 0 UKXUYP+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 34 0 LVUTSU+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 35 0 IKDEMC+MuseoSans-300Italic Type 1 Custom yes yes no 36 0 JRZLDT+MuseoSans-500 Type 1 Custom yes yes no 37 0 CFTLTF+MTGU Type 1 Builtin yes yes no 52 0 IVONAC+MinionPro-It Type 1 Custom yes yes no 220 0 HPSZKK+MTSYN Type 1 Builtin yes yes no 305 0 TMMZQP+RBLMI Type 1 Builtin yes yes no 355 0 JFMESI+MinionPro-Bold Type 1 Custom yes yes no 362 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-02 02:35:22 CET RepresentationInformation: pmc_10157100.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-08-01 02:30:59 CEST Size: 6234171 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1160 FreeObjects: 7 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Adult-specific Reelin expression alters striatal neuronal organization: implications for neuropsychiatric disorders Children: Item: Title: 1. Introduction Item: Title: 2. Materials and methods Children: Item: Title: 2.1. Animals Item: Title: 2.2. PCR genotyping Item: Title: 2.3. Tamoxifen administration Item: Title: 2.4. Immunohistochemistry Item: Title: 2.5. D1-/D2-cell specific mRNA extraction Item: Title: 2.6. Real-time PCR Item: Title: 2.7. Western blot Item: Title: 2.8. Immunohistochemical analysis Item: Title: 2.9. Statistics Item: Title: 3. Results Children: Item: Title: 3.1. Reelin is highly expressed in striatonigral MSNs Item: Title: 3.2. Striatal MSNs organization is independent of Reelin expression levels Item: Title: 3.3. Reelin overexpression alters striatal interneuron population Item: Title: 3.4. Reelin levels control dopaminergic projections Item: Title: 4. Discussion Children: Item: Title: 4.1. A role for Reelin in the striatum Item: Title: 4.2. Reelin, psychiatric behavioral phenotypes, and drug sensitization Item: Title: 4.3. Reelin as a possible therapeutic target for psychiatric diseases Item: Title: Data availability statement Item: Title: Ethics statement Item: Title: Author contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: Conflict of interest Item: Title: Publisher's note Item: Title: References Info: Title: Adult-specific Reelin expression alters striatal neuronal organization: implications for neuropsychiatric disorders Author: Mònica Pardo Subject: Pardo M, Gregorio S, Montalban E, Pujadas L, Elias-Tersa A, Masachs N, Vílchez-Acosta A, Parent A, Auladell C, Girault J-A, Vila M, Nairn AC, Manso Y and Soriano E (2023) Adult-specific Reelin expression alters striatal neuronal organization: implications for neuropsychiatric disorders Front. Cell. Neurosci. 17:1143319. doi: 10.3389/fncel.2023.1143319 Keywords: Reelin, striatum, interneurons, dopamine projections, schizophrenia, Tourette's syndrome Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Thu Apr 13 17:37:38 CEST 2023 ModDate: Thu Apr 13 17:54:33 CEST 2023 ID: 0x9e0dc7c4c9f802d905653d3405b98074, 0x09c82bb85cd6ca48a49fd970353efd64 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: HPSZKK+MTSYN FontSubset: true FirstChar: 0 LastChar: 67 FontDescriptor: FontName: HPSZKK+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: UKXUYP+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 134 LastChar: 134 FontDescriptor: FontName: UKXUYP+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -166, -218, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LVUTSU+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 135 LastChar: 135 FontDescriptor: FontName: LVUTSU+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -166, -214, 1050, 967 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: TMMZQP+RBLMI FontSubset: true FirstChar: 49 LastChar: 60 FontDescriptor: FontName: TMMZQP+RBLMI Flags: Symbolic FontBBox: -11, -230, 987, 750 FontFile: true Font: BaseFont: IKDEMC+MuseoSans-300Italic FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: IKDEMC+MuseoSans-300Italic Flags: Symbolic FontBBox: -245, -210, 1030, 883 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CFTLTF+MTGU FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: CFTLTF+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true Font: BaseFont: JRZLDT+MuseoSans-500 FontSubset: true FirstChar: 2 LastChar: 250 FontDescriptor: FontName: JRZLDT+MuseoSans-500 Flags: Symbolic FontBBox: -121, -210, 1088, 892 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JFMESI+MinionPro-Bold FontSubset: true FirstChar: 44 LastChar: 150 FontDescriptor: FontName: JFMESI+MinionPro-Bold Flags: Symbolic FontBBox: -318, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FLQFJB+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: FLQFJB+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QZNZQI+MuseoSans-700 FontSubset: true FirstChar: 39 LastChar: 150 FontDescriptor: FontName: QZNZQI+MuseoSans-700 Flags: Symbolic FontBBox: -125, -210, 1126, 902 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: IVONAC+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: IVONAC+MinionPro-It Flags: Symbolic FontBBox: -201, -360, 1684, 919 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: NUQBNP+MuseoSans-300 FontSubset: true FirstChar: 2 LastChar: 246 FontDescriptor: FontName: NUQBNP+MuseoSans-300 Flags: Symbolic FontBBox: -118, -210, 1088, 883 FontFile: true EncodingDictionary: Differences: true XMP: Reelin, striatum, interneurons, dopamine projections, schizophrenia, Tourette's syndrome pdfTeX-1.40.15 1.5 True https://www.frontiersin.org/legal/copyright-statement application/pdf fncel-17-1143319.tex Adult-specific Reelin expression alters striatal neuronal organization: implications for neuropsychiatric disorders Pardo M, Gregorio S, Montalban E, Pujadas L, Elias-Tersa A, Masachs N, Vílchez-Acosta A, Parent A, Auladell C, Girault J-A, Vila M, Nairn AC, Manso Y and Soriano E (2023) Adult-specific Reelin expression alters striatal neuronal organization: implications for neuropsychiatric disorders Front. Cell. Neurosci. 17:1143319. doi: 10.3389/fncel.2023.1143319 Copyright © 2023 Pardo, Gregorio, Montalban, Pujadas, Elias-Tersa, Masachs, Vílchez-Acosta, Parent, Auladell, Girault, Vila, Nairn, Manso and Soriano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Mònica Pardo Sara Gregorio Enrica Montalban Lluís Pujadas Alba Elias-Tersa Núria Masachs Alba Vílchez-Acosta Annabelle Parent Carme Auladell Jean-Antoine Girault Miquel Vila Angus C. Nairn Yasmina Manso Eduardo Soriano 2023-04-13T20:37:38+05:30 Reelin striatum interneurons dopamine projections schizophrenia Tourette's syndrome 2023-04-13T20:37:38+05:30 2023-04-13T20:54:33+05:30 2023-04-13T20:54:33+05:30 LaTeX with hyperref package uuid:dcea39bb-b188-4d7f-9188-82bbbb62b182 uuid:f4fa9314-3800-4eca-bc33-ed031b3a8e65 Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 48, 791, 272, 807 Annotation: Subtype: Link Rect: 433, 798, 514, 807 Annotation: Subtype: Link Rect: 433, 789, 518, 798 Annotation: Subtype: Link Rect: 433, 779, 544, 789 Annotation: Subtype: Link Rect: 48, 704, 126, 721 Annotation: Subtype: Link Rect: 62, 227, 154, 234 Annotation: Subtype: Link Rect: 158, 168, 186, 175 Annotation: Subtype: Link Rect: 48, 159, 84, 166 Annotation: Subtype: Link Rect: 84, 159, 120, 166 Annotation: Subtype: Link Rect: 120, 159, 146, 166 Annotation: Subtype: Link Rect: 146, 159, 172, 166 Annotation: Subtype: Link Rect: 213, 625, 546, 722 Annotation: Subtype: 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