df47838e7d5f55208417344217a7cc82  pmc_10160086.pdf
7957574729dd01f591139a1f7a4cde80143829bc  pmc_10160086.pdf
276d539b45a2b2a534f05111918ad61eb20d7caff3557708a42a5fb3afd99e4b  pmc_10160086.pdf

Title:          Integrated gene expression profiles reveal a transcriptomic network underlying the thermogenic response in adipose tissue
Subject:        Scientific Reports, https://doi.org/10.1038/s41598-023-33367-w
Author:         Jordi Rodó 
Creator:        Springer
Producer:       Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:   Thu May  4 13:14:03 2023 CEST
ModDate:        Thu May  4 15:19:58 2023 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          13
Encrypted:      no
Page size:      595.276 x 782.362 pts
Page rot:       0
File size:      6878053 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MVQEXF+Wingdings-Regular             Type 1C           WinAnsi          yes yes yes    508  0
MinionPro-Regular                    Type 1C           Custom           yes no  yes     21  0
ULIXDU+Corbel-Bold                   CID TrueType      Identity-H       yes yes yes     23  0
Corbel2                              TrueType          WinAnsi          yes no  yes     24  0
FJWVBY+Corbel                        CID TrueType      Identity-H       yes yes yes     25  0
Corbel3                              CID TrueType      Identity-H       yes no  yes    544  0
Corbel4                              TrueType          WinAnsi          yes no  yes     66  0
MinionPro-Bold                       Type 1C           Custom           yes no  yes     22  0
MinionPro-It                         Type 1C           Custom           yes no  yes     61  0
RMMLKA+TimesNewRomanPSMT             TrueType          WinAnsi          yes yes yes    297  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-01-11 02:29:50 CET
 RepresentationInformation: pmc_10160086.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2023-12-02 02:19:00 CET
  Size: 6878053
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 590
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Integrated gene expression profiles reveal a transcriptomic network underlying the thermogenic response in adipose tissue
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Analysis of gene expression profiles of adipose depots during induction of non-shivering thermogenesis. 
         Item: 
          Title: Specific transcriptomic changes triggered by cold adaptation. 
         Item: 
          Title: Protein–protein interaction network analysis of DEGs. 
         Item: 
          Title: Identification of transcription factors regulating iWAT network of DEGs. 
         Item: 
          Title: Differentially expressed miRNAs. 
         Item: 
          Title: Gene regulatory network of iWAT​. 
       Item: 
        Title: Discussion
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Animal procedures. 
         Item: 
          Title: Microarray analysis of miRNA and mRNA. 
         Item: 
          Title: Differential expression analysis. 
         Item: 
          Title: Functional analysis. 
         Item: 
          Title: Construction of protein–protein interaction (PPI) network. 
         Item: 
          Title: MiRNA-target network construction. 
         Item: 
          Title: Identification of regulatory transcription factors. 
         Item: 
          Title: Gene expression quantification by real-time quantitative PCR (qRT–PCR). 
         Item: 
          Title: Histology. 
       Item: 
        Title: References
       Item: 
        Title: Acknowledgements
   Info: 
    Title: Integrated gene expression profiles reveal a transcriptomic network underlying the thermogenic response in adipose tissue
    Author: Jordi Rodó 
    Subject: Scientific Reports, https://doi.org/10.1038/s41598-023-33367-w
    Creator: Springer
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Thu May 04 13:44:03 CEST 2023
    ModDate: Thu May 04 15:19:58 CEST 2023
   ID: 0x0664aa4f7656b2f10481db2d4639848e, 0xf3c15612f22df4503ac456bb4ee8c466
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1772
      ImageHeight: 1387
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1772
      ImageHeight: 1296
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1680
      ImageHeight: 2362
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1695
      ImageHeight: 2362
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1772
      ImageHeight: 1403
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1772
      ImageHeight: 1447
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: ULIXDU+Corbel-Bold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: FJWVBY+Corbel
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: MinionPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -290, -360, 1684, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -319, -360, 1684, 1024
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MVQEXF+Wingdings-Regular
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MVQEXF+Wingdings-Regular
       Flags: Nonsymbolic
       FontBBox: 0, -103, 1359, 439
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -201, -360, 1684, 1002
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: Corbel2
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Corbel2
       Flags: Nonsymbolic
       FontBBox: -553, -239, 1110, 952
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: RMMLKA+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: RMMLKA+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: ULIXDU+Corbel-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: ULIXDU+Corbel-Bold
       Flags: Symbolic
       FontBBox: -556, -239, 1155, 952
       FontFile2: true
     Font: 
      BaseFont: WAMQZQ+Corbel
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: WAMQZQ+Corbel
       Flags: Symbolic
       FontBBox: -553, -239, 1110, 952
       FontFile2: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2019/10/10-02:41:22        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2023-05-04T16:44:03+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2023-05-04T15:19:58+02:00</xmp:ModifyDate>
         <xmp:MetadataDate>2023-05-04T15:19:58+02:00</xmp:MetadataDate>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1038/s41598-023-33367-w</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Nature Publishing Group UK</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Scientific Reports, https://doi.org/10.1038/s41598-023-33367-w</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Integrated gene expression profiles reveal a transcriptomic network underlying the thermogenic response in adipose tissue</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Jordi Rodó </rdf:li>
               <rdf:li>Miquel Garcia </rdf:li>
               <rdf:li>Estefania Casana </rdf:li>
               <rdf:li>Sergio Muñoz </rdf:li>
               <rdf:li>Claudia Jambrina </rdf:li>
               <rdf:li>Victor Sacristan </rdf:li>
               <rdf:li>Sylvie Franckhauser </rdf:li>
               <rdf:li>Ignasi Grass </rdf:li>
               <rdf:li>Veronica Jimenez </rdf:li>
               <rdf:li>Fatima Bosch </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1038/s41598-023-33367-w</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1038/s41598-023-33367-w</prism:url>
         <prism:doi>10.1038/s41598-023-33367-w</prism:doi>
         <prism:issn>2045-2322</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Scientific Reports</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1038/s41598-023-33367-w</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:8ba949c7-89c1-4f49-9b2a-96b4c4de40a1</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:8bd8d442-c321-48fd-8f74-11cdbd10f3e7</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:889591b9-43cb-4254-9f86-02950f8f9cec</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2023-05-04T16:45:26+05:30</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:c604164d-d149-4f9c-bce5-9207f6766552</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2023-05-04T16:46:04+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 334, 302, 336, 290
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 184, 262, 187, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 188, 262, 191, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 549, 232, 552, 220
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 417, 212, 420, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 423, 212, 426, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 203, 192, 206, 180
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 209, 192, 212, 180
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 289, 162, 292, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 430, 142, 433, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 436, 142, 442, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 481, 675, 556, 658
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 199, 734, 205, 722
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 366, 654, 371, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 375, 654, 380, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 200, 502, 204, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 488, 492, 493, 480
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 494, 724, 498, 712
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 276, 704, 280, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 246, 684, 250, 672
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 487, 674, 492, 662
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 543, 664, 547, 652
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 384, 612, 388, 600
       Flags: Print
       AppearanceDictionary: true
       Destination: 34
      Annotation: 
       Subtype: Link
       Rect: 391, 582, 395, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 34
      Annotation: 
       Subtype: Link
       Rect: 403, 562, 407, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 34
      Annotation: 
       Subtype: Link
       Rect: 394, 552, 398, 540
       Flags: Print
       AppearanceDictionary: true
       Destination: 34
      Annotation: 
       Subtype: Link
       Rect: 268, 532, 272, 520
       Flags: Print
       AppearanceDictionary: true
       Destination: 34
      Annotation: 
       Subtype: Link
       Rect: 243, 512, 248, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 34
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 443, 714, 448, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: 34
      Annotation: 
       Subtype: Link
       Rect: 419, 704, 423, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 34
      Annotation: 
       Subtype: Link
       Rect: 367, 642, 372, 630
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 543, 632, 548, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 543, 622, 547, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 198, 602, 202, 590
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 239, 562, 244, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 448, 552, 452, 540
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 453, 522, 458, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 421, 512, 425, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 195, 430, 201, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 341, 430, 347, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 348, 430, 354, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 448, 400, 452, 388
       Flags: Print
       AppearanceDictionary: true
       Destination: 151
      Annotation: 
       Subtype: Link
       Rect: 233, 370, 237, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 151
      Annotation: 
       Subtype: Link
       Rect: 321, 340, 326, 328
       Flags: Print
       AppearanceDictionary: true
       Destination: 151
      Annotation: 
       Subtype: Link
       Rect: 446, 330, 451, 318
       Flags: Print
       AppearanceDictionary: true
       Destination: 151
      Annotation: 
       Subtype: Link
       Rect: 295, 320, 300, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 151
      Annotation: 
       Subtype: Link
       Rect: 261, 290, 265, 278
       Flags: Print
       AppearanceDictionary: true
       Destination: 151
      Annotation: 
       Subtype: Link
       Rect: 361, 280, 365, 268
       Flags: Print
       AppearanceDictionary: true
       Destination: 151
      Annotation: 
       Subtype: Link
       Rect: 543, 270, 547, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 151
      Annotation: 
       Subtype: Link
       Rect: 279, 250, 284, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 151
      Annotation: 
       Subtype: Link
       Rect: 276, 188, 281, 176
       Flags: Print
       AppearanceDictionary: true
       Destination: 161
      Annotation: 
       Subtype: Link
       Rect: 219, 178, 224, 166
       Flags: Print
       AppearanceDictionary: true
       Destination: 161
      Annotation: 
       Subtype: Link
       Rect: 518, 178, 522, 166
       Flags: Print
       AppearanceDictionary: true
       Destination: 161
      Annotation: 
       Subtype: Link
       Rect: 174, 158, 178, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 161
      Annotation: 
       Subtype: Link
       Rect: 348, 148, 352, 136
       Flags: Print
       AppearanceDictionary: true
       Destination: 161
      Annotation: 
       Subtype: Link
       Rect: 236, 128, 242, 116
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 245, 128, 250, 116
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 464, 96, 468, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 151
      Annotation: 
       Subtype: Link
       Rect: 487, 96, 492, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 161
      Annotation: 
       Subtype: Link
       Rect: 274, 86, 279, 74
       Flags: Print
       AppearanceDictionary: true
       Destination: 176
      Annotation: 
       Subtype: Link
       Rect: 368, 76, 372, 64
       Flags: Print
       AppearanceDictionary: true
       Destination: 176
     Thumb: true
    Page: 
     Sequence: 5
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 544, 69, 549, 57
       Flags: Print
       AppearanceDictionary: true
       Destination: 176
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 393, 296, 399, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 318, 276, 322, 264
       Flags: Print
       AppearanceDictionary: true
       Destination: 176
      Annotation: 
       Subtype: Link
       Rect: 420, 266, 424, 254
       Flags: Print
       AppearanceDictionary: true
       Destination: 176
      Annotation: 
       Subtype: Link
       Rect: 277, 236, 281, 224
       Flags: Print
       AppearanceDictionary: true
       Destination: 176
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 423, 239, 429, 227
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 430, 239, 436, 227
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 361, 219, 367, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 192, 199, 197, 187
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 446, 189, 452, 177
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 453, 189, 459, 177
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 525, 69, 531, 57
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 532, 69, 538, 57
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 421, 365, 495, 353
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 458, 724, 463, 712
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 466, 724, 472, 712
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 231, 654, 236, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 417, 614, 422, 602
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 295, 524, 301, 512
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 438, 514, 443, 502
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 332, 494, 338, 482
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 339, 494, 345, 482
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 383, 474, 389, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 390, 474, 396, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 412, 464, 418, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 510, 434, 516, 422
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 483, 414, 489, 402
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 423, 384, 429, 372
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 430, 384, 436, 372
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 437, 384, 443, 372
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 352, 344, 358, 332
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 367, 284, 373, 272
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 411, 244, 416, 232
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 182, 234, 188, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 189, 234, 195, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 441, 402, 447, 390
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 268, 278, 274, 266
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 277, 278, 283, 266
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 192, 206, 198, 194
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 199, 206, 205, 194
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 199, 154, 205, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 206, 154, 211, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 444, 112, 450, 100
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 451, 112, 457, 100
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 209, 102, 215, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 364, 102, 370, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 465, 82, 470, 70
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 260, 734, 266, 722
       Flags: Print
       AppearanceDictionary: true
       Destination: 278
      Annotation: 
       Subtype: Link
       Rect: 267, 734, 273, 722
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 232, 522, 237, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 202, 440, 440, 428
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 440, 554, 428
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 155, 430, 347, 418
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 12
     Thumb: true
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 499, 692, 554, 680
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 155, 682, 261, 670
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 351, 652, 443, 640
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 358, 542, 517, 530
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: d9848fa8
   Type: CRC32
  Checksum: df47838e7d5f55208417344217a7cc82
   Type: MD5
  Checksum: 7957574729dd01f591139a1f7a4cde80143829bc
   Type: SHA-1
  Checksum: 276d539b45a2b2a534f05111918ad61eb20d7caff3557708a42a5fb3afd99e4b
   Type: SHA-256