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Title:          G protein-coupled receptor 183 mediates the sensitization of Burkitt lymphoma tumors to CD47 immune checkpoint blockade by anti-CD20/PI3Kdi dual therapy
Subject:        Ribeiro ML, Profitós-Pelejà N, Santos JC, Blecua P, Reyes-Garau D, Armengol M, Fernández-Serrano M, Miskin HP, Bosch F, Esteller M, Normant E and Roué G (2023) G protein-coupled receptor 183 mediates the sensitization of Burkitt lymphoma tumors to CD47 i
Keywords:       B-NHL, immune checkpoint blockade, drug combination, ADCP, M1 macrophage, 3D spheroid, CAM assay, inflammatory receptor
Author:         Marcelo Lima Ribeiro
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      Title: G protein-coupled receptor 183 mediates the sensitization of Burkitt lymphoma tumors to CD47 immune checkpoint blockade by anti-CD20/PI3Kδi dual therapy
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      Children: 
       Item: 
        Title: 1 Introduction
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       Item: 
        Title: 2 Materials and methods
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        Children: 
         Item: 
          Title: 2.1 Cell lines
          Destination: s2_1
         Item: 
          Title: 2.2 Occupancy assay
          Destination: s2_2
         Item: 
          Title: 2.3 Peripheral blood mononuclear cells isolation and macrophage polarization
          Destination: s2_3
         Item: 
          Title: 2.4 Antibody-dependent cell-mediated cytotoxicity and phagocytosis assays
          Destination: s2_4
         Item: 
          Title: 2.5 Xenograft mouse model and tumor immunophenotyping
          Destination: s2_5
         Item: 
          Title: 2.6 Chicken embryo chorioallantoic membrane model
          Destination: s2_6
         Item: 
          Title: 2.7 RNA sequencing analysis
          Destination: s2_7
         Item: 
          Title: 2.8 Generation of Raji-GPR183KO cells
          Destination: s2_8
         Item: 
          Title: 2.9 Western blot analysis
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         Item: 
          Title: 2.10 3D multicellular spheroid generation
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         Item: 
          Title: 2.11 Transwell migration assay and F-actin staining
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         Item: 
          Title: 2.12 Ethics
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         Item: 
          Title: 2.13 Statistical analysis
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       Item: 
        Title: 3 Results
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        Children: 
         Item: 
          Title: 3.1 Anti-CD20/PI3Kδi dual asset cooperates with CD47 blockade therapy in CD19+ B-cell tumors
          Destination: s3_1
         Item: 
          Title: 3.2 GPR183 is upregulated in response to CD47/CD20/PI3Kδi triplet treatment
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         Item: 
          Title: 3.3 GPR183 is required for B-cell trafficking and macrophage-dependent phagocytosis after the triplet treatment
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        Title: 4 Discussion
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       Item: 
        Title: Data availability statement
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       Item: 
        Title: Author contributions
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        Title: Funding
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        Title: Acknowledgments
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       Item: 
        Title: Supplementary material
        Destination: bmark_632582120
       Item: 
        Title: References
        Destination: bmark_2090415954
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    Title: G protein-coupled receptor 183 mediates the sensitization of Burkitt lymphoma tumors to CD47 immune checkpoint blockade by anti-CD20/PI3Kdi dual therapy
    Author: Marcelo Lima Ribeiro
    Subject: Ribeiro ML, Profitós-Pelejà N, Santos JC, Blecua P, Reyes-Garau D, Armengol M, Fernández-Serrano M, Miskin HP, Bosch F, Esteller M, Normant E and Roué G (2023) G protein-coupled receptor 183 mediates the sensitization of Burkitt lymphoma tumors to CD47 i
    Keywords: B-NHL, immune checkpoint blockade, drug combination, ADCP, M1 macrophage, 3D spheroid, CAM assay, inflammatory receptor
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   Type: CRC32
  Checksum: e9840d377a7cdeda2d8a6545a2bd504e
   Type: MD5
  Checksum: 5fa91dee9ad4e1632c919dcaee7d9ed1c00a98d4
   Type: SHA-1
  Checksum: aeb40576b1dc5bf511ab16a489d99638a964b9e025758a96a9fc015594ee5bf1
   Type: SHA-256