621d376c2cde1ca4846dd2e034680263 pmc_10177401.pdf 94268bfeab6cfae4ad55e54c7043db870958e3ae pmc_10177401.pdf 4bd3e451327c2ea869d9fc32d61f2f558e49f4689516a19355788e12fd0eb317 pmc_10177401.pdf Title: Quality of Life after Mandibular Reconstruction Using Free Fibula Flap and Customized Plates: A Case Series and Comparison with the Literature Subject: A single-center retrospective study was conducted to assess health-related quality of life (HRQoL) in 23 consecutive patients undergoing mandibular reconstruction using the computer-aided design (CAD) and computer-aided manufacturing (CAM) technology, free fibula flap, and titanium patient-specific implants (PSIs). HRQoL was evaluated after at least 12 months of surgery using the University of Washington Quality of Life (UW-QOL) questionnaire for head and neck cancer patients. In the 12 single question domains, the highest mean scores were found for “taste” (92.9), “shoulder” (90.9), “anxiety” (87.5), and “pain” (86.4), whereas the lowest scores were observed for “chewing” (57.1), “appearance” (67.9), and “saliva” (78.1). In the three global questions of the UW-QOL questionnaire, 80% of patients considered that their HRQoL was as good as or even better than it was compared to their HRQoL before cancer, and only 20% reported that their HRQoL had worsened after the presence of the disease. Overall QoL during the past 7 days was rated as good, very good or outstanding by 81% of patients, respectively. No patient reported poor or very poor QoL. In the present study, restoring mandibular continuity with free fibula flap and patient-specific titanium implants designed with the CAD-CAM technology improved HRQoL. Keywords: quality of life; mandibular reconstruction; free fibula flap; patient-specific implant; plates; University of Washington Quality of Life Questionnaire Author: Jorge Pamias-Romero, Manel Saez-Barba, Alba de-Pablo-García-Cuenca, Pablo Vaquero-Martínez, Joan Masnou-Pratdesaba and Coro Bescós-Atín Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri May 5 08:22:21 2023 CEST ModDate: Fri May 5 08:38:44 2023 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 925623 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KPNHET+VnURWPalladioL Type 1 Custom yes yes no 10 0 XOSZEH+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 BIMGTD+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 LUNIFU+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 YWWVQQ+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 47 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 72 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 76 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 80 0 BCDHEE+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 84 0 BCDIEE+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 90 0 BCDJEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 96 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 108 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 112 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 116 0 BCDHEE+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 120 0 BCDIEE+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 126 0 BCDJEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 132 0 URYLRZ+URWPalladioL-BoldItal Type 1 Custom yes yes no 158 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-09-01 08:22:26 CEST RepresentationInformation: pmc_10177401.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-07-06 02:32:12 CEST Size: 925623 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 314 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design and Participants Destination: subsection.2.1 Item: Title: Protocol for Mandibular Reconstruction with Free Fibula Flap Destination: subsection.2.2 Item: Title: Evaluation and Follow-up Destination: subsection.2.3 Item: Title: Health-Related Quality of Life Destination: subsection.2.4 Item: Title: Study Outcomes Destination: subsection.2.5 Item: Title: Statistical Analysis Destination: subsection.2.6 Item: Title: Results Destination: section.3 Children: Item: Title: Clinical and Surgical Characteristics Destination: subsection.3.1 Item: Title: Health-Related Quality of Life Destination: subsection.3.2 Item: Title: PSI-Related Complications Destination: subsection.3.3 Item: Title: PEEK Prosthesis-Related Complications Destination: subsection.3.4 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Quality of Life after Mandibular Reconstruction Using Free Fibula Flap and Customized Plates: A Case Series and Comparison with the Literature Author: Jorge Pamias-Romero, Manel Saez-Barba, Alba de-Pablo-García-Cuenca, Pablo Vaquero-Martínez, Joan Masnou-Pratdesaba and Coro Bescós-Atín Subject: A single-center retrospective study was conducted to assess health-related quality of life (HRQoL) in 23 consecutive patients undergoing mandibular reconstruction using the computer-aided design (CAD) and computer-aided manufacturing (CAM) technology, free fibula flap, and titanium patient-specific implants (PSIs). HRQoL was evaluated after at least 12 months of surgery using the University of Washington Quality of Life (UW-QOL) questionnaire for head and neck cancer patients. In the 12 single question domains, the highest mean scores were found for “taste” (92.9), “shoulder” (90.9), “anxiety” (87.5), and “pain” (86.4), whereas the lowest scores were observed for “chewing” (57.1), “appearance” (67.9), and “saliva” (78.1). In the three global questions of the UW-QOL questionnaire, 80% of patients considered that their HRQoL was as good as or even better than it was compared to their HRQoL before cancer, and only 20% reported that their HRQoL had worsened after the presence of the disease. Overall QoL during the past 7 days was rated as good, very good or outstanding by 81% of patients, respectively. No patient reported poor or very poor QoL. In the present study, restoring mandibular continuity with free fibula flap and patient-specific titanium implants designed with the CAD-CAM technology improved HRQoL. 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