e31c31bd69c02665fa46c4bf01536aeb pmc_10182650.pdf 0cec15236f052cc460f94fa227b139c746f4cd5c pmc_10182650.pdf 02d8a38688b263ef2416f0f1bbeb02f362e048869e4a80f7d72db1a1b547b45b pmc_10182650.pdf Title: Mycobacterium manresensis induces trained immunity in vitro Subject: ISCIENCE, 26 (2023) 106873. doi:10.1016/j.isci.2023.106873 Author: Miquel de Homdedeu Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri May 26 16:56:04 2023 CEST ModDate: Fri May 26 16:57:31 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 28 Encrypted: no Page size: 602.986 x 782.986 pts Page rot: 0 File size: 4181796 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GEKNMB+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 1921 0 GEKNMC+AdvPSA5BC Type 1C WinAnsi yes yes no 1924 0 GEKNMD+AdvPSA5CE Type 1C WinAnsi yes yes no 1927 0 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'bib82' cannot be found Offset: 4134080 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib38' cannot be found Offset: 4134080 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib83' cannot be found Offset: 4134080 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 2026 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: ISCI106873_proof_v26i6.pdf Children: Item: Title: Mycobacterium manresensis induces trained immunity in vitro Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: hkMm induces trained immunity in the human monocytic THP-1 cell line Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: hkMm induces trained immunity in human primary monocytes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: hkMm induces epigenetic modifications in human monocytes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Oral administration of hkMm does not influence SARS-CoV-2 infection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Oral administration of hkMm does not modify the inflammatory responses of peripheral blood monocytes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Oral administration of hkMm changes the profile of circulating immune cell populations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: Limitations of the study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Supplemental information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Declaration of interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: STAR★Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: Key resources table Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Resource availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: Lead contact Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Materials availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Data and code availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Experimental model and subject details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Children: Item: Title: Trained immunity model in THP-1 monocytes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Trained immunity in primary monocytes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Manrecovid19 clinical trial Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Children: Item: Title: Design and participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Data collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Randomization and masking Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Outcomes and follow-up Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Method details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Children: Item: Title: Reagents Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Monocyte isolation from buffy coats Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Functional analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Metabolic activity assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: RNA extraction and quantitative RT-PCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Chromatin immunoprecipitation analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Leukocyte staining for flow cytometry analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: In vitro stimulation of monocytes from MANRECOVID19 clinical trial Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Cytokine measurements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Quantification and statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: Additional resources Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Info: Title: Mycobacterium manresensis induces trained immunity in vitro Author: Miquel de Homdedeu Subject: ISCIENCE, 26 (2023) 106873. 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doi:10.1016/j.isci.2023.106873 Mycobacterium manresensis induces trained immunity in vitro Miquel de Homdedeu Lidia Sanchez-Moral Concepció Violán Neus Ràfols Dan Ouchi Berta Martín Miguel A. Peinado Alhelí Rodríguez-Cortés Marta Arch-Sisquella Daniel Perez-Zsolt Jordana Muñoz-Basagoiti Nuria Izquierdo-Useros Betlem Salvador Joan Matllo Sergi López-Serrano Joaquim Segalés Cristina Vilaplana Pere Torán-Monserrat Rosa Morros Ramon Monfà Maria-Rosa Sarrias Pere-Joan Cardona Biological sciences Molecular biology Immunology Microbiology ISCIENCE, 26 (2023) 106873. doi:10.1016/j.isci.2023.106873 The Authors journal ISCIENCE © 2023 The Authors. 2589-0042 26 6 16 June 2023 2023-06-16 106873 106873 10.1016/j.isci.2023.106873 https://doi.org/10.1016/j.isci.2023.106873 2010-04-23 true 10.1016/j.isci.2023.106873 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.isci.2023.106873 noindex true 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2023-05-26T20:26:04+05:30 2023-05-26T20:27:31+05:30 2023-05-26T20:27:31+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:8ae714e5-b184-4379-9b01-1fd4cdc063a9 uuid:1699a14f-8b8e-4aa0-a76c-609ce86c04df 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Annotation: Subtype: Link Rect: 238, 89, 373, 96 Annotation: Subtype: Link Rect: 238, 81, 336, 88 Annotation: Subtype: Link Rect: 238, 73, 347, 80 Annotation: Subtype: Link Rect: 238, 65, 353, 72 Annotation: Subtype: Link Rect: 238, 57, 361, 64 Annotation: Subtype: Link Rect: 238, 49, 265, 56 Annotation: Subtype: Link Rect: 406, 346, 544, 353 Annotation: Subtype: Link Rect: 406, 338, 533, 345 Annotation: Subtype: Link Rect: 406, 330, 530, 337 Annotation: Subtype: Link Rect: 406, 322, 544, 329 Annotation: Subtype: Link Rect: 406, 314, 518, 321 Annotation: Subtype: Link Rect: 406, 306, 539, 313 Annotation: Subtype: Link Rect: 406, 298, 503, 305 Annotation: Subtype: Link Rect: 406, 282, 539, 289 Annotation: Subtype: Link Rect: 406, 274, 544, 281 Annotation: Subtype: Link Rect: 406, 266, 543, 273 Annotation: Subtype: Link Rect: 406, 258, 434, 265 Annotation: Subtype: Link Rect: 406, 241, 530, 248 Annotation: Subtype: Link Rect: 406, 233, 541, 240 Annotation: Subtype: Link Rect: 406, 225, 544, 232 Annotation: Subtype: Link Rect: 406, 217, 475, 224 Annotation: Subtype: Link Rect: 406, 201, 531, 208 Annotation: Subtype: Link Rect: 406, 193, 544, 200 Annotation: Subtype: Link Rect: 406, 185, 538, 192 Annotation: Subtype: Link Rect: 406, 177, 544, 184 Annotation: Subtype: Link Rect: 406, 169, 461, 176 Annotation: Subtype: Link Rect: 406, 153, 528, 160 Annotation: Subtype: Link Rect: 406, 145, 523, 152 Annotation: Subtype: Link Rect: 406, 137, 532, 144 Annotation: Subtype: Link Rect: 406, 129, 544, 136 Annotation: Subtype: Link Rect: 406, 121, 534, 128 Annotation: Subtype: Link Rect: 406, 113, 534, 120 Annotation: Subtype: Link Rect: 406, 105, 541, 112 Annotation: Subtype: Link Rect: 406, 89, 518, 96 Annotation: Subtype: Link Rect: 406, 81, 526, 88 Annotation: Subtype: Link Rect: 406, 73, 539, 80 Annotation: Subtype: Link Rect: 406, 65, 534, 72 Annotation: Subtype: Link Rect: 406, 57, 541, 64 Annotation: Subtype: Link Rect: 406, 49, 465, 56 Page: Label: 17 Annotations: 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Annotation: Subtype: Link Rect: 69, 496, 206, 503 Annotation: Subtype: Link Rect: 69, 488, 160, 495 Annotation: Subtype: Link Rect: 69, 472, 199, 479 Annotation: Subtype: Link Rect: 69, 464, 208, 471 Annotation: Subtype: Link Rect: 69, 456, 195, 463 Annotation: Subtype: Link Rect: 69, 448, 194, 455 Annotation: Subtype: Link Rect: 69, 440, 196, 447 Annotation: Subtype: Link Rect: 69, 432, 187, 439 Annotation: Subtype: Link Rect: 69, 424, 128, 431 Annotation: Subtype: Link Rect: 69, 408, 193, 415 Annotation: Subtype: Link Rect: 69, 400, 191, 407 Annotation: Subtype: Link Rect: 69, 392, 198, 399 Annotation: Subtype: Link Rect: 69, 384, 208, 391 Annotation: Subtype: Link Rect: 69, 376, 208, 383 Annotation: Subtype: Link Rect: 69, 368, 201, 375 Annotation: Subtype: Link Rect: 69, 360, 159, 367 Annotation: Subtype: Link Rect: 131, 336, 206, 343 Annotation: Subtype: Link Rect: 69, 320, 208, 327 Annotation: Subtype: Link Rect: 69, 312, 205, 319 Annotation: Subtype: Link Rect: 69, 304, 207, 311 Annotation: Subtype: Link Rect: 69, 296, 197, 303 Annotation: Subtype: Link Rect: 69, 288, 206, 295 Annotation: Subtype: Link Rect: 69, 280, 185, 287 Annotation: Subtype: Link Rect: 69, 272, 135, 279 Annotation: Subtype: Link Rect: 69, 256, 195, 263 Annotation: Subtype: Link Rect: 69, 248, 186, 255 Annotation: Subtype: Link Rect: 69, 240, 192, 247 Annotation: Subtype: Link Rect: 69, 232, 174, 239 Annotation: Subtype: Link Rect: 69, 224, 185, 231 Annotation: Subtype: Link Rect: 69, 216, 203, 223 Annotation: Subtype: Link Rect: 69, 208, 202, 215 Annotation: Subtype: Link Rect: 69, 200, 165, 207 Annotation: Subtype: Link Rect: 69, 184, 195, 191 Annotation: Subtype: Link Rect: 69, 176, 194, 183 Annotation: Subtype: Link Rect: 69, 168, 206, 175 Annotation: Subtype: Link Rect: 69, 160, 194, 167 Annotation: Subtype: Link Rect: 69, 152, 208, 159 Annotation: Subtype: Link Rect: 69, 144, 203, 151 Annotation: Subtype: Link Rect: 69, 136, 180, 143 Annotation: Subtype: Link Rect: 69, 128, 208, 135 Annotation: Subtype: Link Rect: 69, 120, 204, 127 Annotation: Subtype: Link Rect: 69, 112, 114, 119 Annotation: Subtype: Link Rect: 69, 96, 200, 103 Annotation: Subtype: Link Rect: 69, 88, 205, 95 Annotation: Subtype: Link Rect: 69, 80, 201, 87 Annotation: Subtype: Link Rect: 69, 72, 196, 79 Annotation: Subtype: Link Rect: 69, 64, 198, 71 Annotation: Subtype: Link Rect: 69, 56, 205, 63 Annotation: Subtype: Link Rect: 69, 48, 198, 55 Annotation: Subtype: Link Rect: 238, 672, 376, 679 Annotation: Subtype: Link Rect: 238, 664, 352, 671 Annotation: Subtype: Link Rect: 238, 656, 263, 663 Annotation: Subtype: Link Rect: 238, 640, 362, 647 Annotation: Subtype: Link Rect: 238, 632, 358, 639 Annotation: Subtype: Link Rect: 238, 624, 367, 631 Annotation: Subtype: Link Rect: 238, 616, 366, 623 Annotation: Subtype: Link Rect: 238, 608, 375, 615 Annotation: Subtype: Link Rect: 238, 600, 361, 607 Annotation: Subtype: Link Rect: 238, 592, 361, 599 Annotation: Subtype: Link Rect: 238, 584, 367, 591 Annotation: Subtype: Link Rect: 238, 576, 370, 583 Annotation: Subtype: Link Rect: 238, 568, 376, 575 Annotation: Subtype: Link Rect: 238, 560, 334, 567 Annotation: Subtype: Link Rect: 238, 544, 371, 551 Annotation: Subtype: Link Rect: 238, 536, 376, 543 Annotation: Subtype: Link Rect: 238, 528, 341, 535 Annotation: Subtype: Link Rect: 345, 528, 366, 535 Annotation: Subtype: Link Rect: 238, 520, 376, 527 Annotation: Subtype: Link Rect: 238, 512, 368, 519 Annotation: Subtype: Link Rect: 238, 504, 361, 511 Annotation: Subtype: Link Rect: 238, 496, 376, 503 Annotation: Subtype: Link Rect: 238, 488, 376, 495 Annotation: Subtype: Link Rect: 238, 480, 367, 487 Annotation: Subtype: Link Rect: 238, 472, 376, 479 Annotation: Subtype: Link Rect: 238, 464, 290, 471 Annotation: Subtype: Link Rect: 238, 448, 375, 455 Annotation: Subtype: Link Rect: 238, 440, 362, 447 Annotation: Subtype: Link Rect: 238, 432, 376, 439 Annotation: Subtype: Link Rect: 238, 424, 360, 431 Annotation: Subtype: Link Rect: 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Subtype: Link Rect: 238, 241, 367, 247 Annotation: Subtype: Link Rect: 238, 233, 363, 239 Annotation: Subtype: Link Rect: 238, 225, 298, 231 Annotation: Subtype: Link Rect: 238, 208, 373, 215 Annotation: Subtype: Link Rect: 238, 200, 372, 207 Annotation: Subtype: Link Rect: 238, 192, 360, 199 Annotation: Subtype: Link Rect: 238, 184, 346, 191 Annotation: Subtype: Link Rect: 238, 176, 365, 183 Annotation: Subtype: Link Rect: 238, 169, 349, 175 Annotation: Subtype: Link Rect: 238, 161, 370, 167 Annotation: Subtype: Link Rect: 238, 153, 372, 160 Annotation: Subtype: Link Rect: 238, 145, 339, 152 Annotation: Subtype: Link Rect: 238, 128, 367, 135 Annotation: Subtype: Link Rect: 238, 120, 368, 127 Annotation: Subtype: Link Rect: 238, 112, 376, 119 Annotation: Subtype: Link Rect: 238, 104, 368, 111 Annotation: Subtype: Link Rect: 238, 97, 340, 103 Annotation: Subtype: Link Rect: 238, 89, 359, 96 Annotation: Subtype: Link Rect: 238, 81, 313, 88 Annotation: Subtype: Link Rect: 461, 648, 539, 655 Annotation: Subtype: Link Rect: 406, 640, 451, 647 Annotation: Subtype: Link Rect: 406, 623, 544, 630 Annotation: Subtype: Link Rect: 406, 615, 538, 622 Annotation: Subtype: Link Rect: 406, 607, 544, 614 Annotation: Subtype: Link Rect: 406, 599, 528, 606 Annotation: Subtype: Link Rect: 406, 591, 522, 598 Annotation: Subtype: Link Rect: 406, 583, 511, 590 Annotation: Subtype: Link Rect: 516, 583, 544, 590 Annotation: Subtype: Link Rect: 406, 576, 544, 582 Annotation: Subtype: Link Rect: 406, 568, 535, 574 Annotation: Subtype: Link Rect: 406, 551, 536, 558 Annotation: Subtype: Link Rect: 406, 543, 518, 550 Annotation: Subtype: Link Rect: 406, 535, 534, 542 Annotation: Subtype: Link Rect: 406, 527, 473, 534 Annotation: Subtype: Link Rect: 406, 510, 523, 517 Annotation: Subtype: Link Rect: 406, 502, 533, 509 Annotation: Subtype: Link Rect: 406, 494, 526, 501 Annotation: Subtype: Link Rect: 406, 486, 528, 493 Annotation: Subtype: Link Rect: 406, 478, 524, 485 Annotation: Subtype: Link 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Annotation: Subtype: Link Rect: 406, 284, 533, 291 Annotation: Subtype: Link Rect: 406, 276, 464, 283 Annotation: Subtype: Link Rect: 406, 259, 544, 266 Annotation: Subtype: Link Rect: 406, 251, 543, 258 Annotation: Subtype: Link Rect: 406, 243, 527, 250 Annotation: Subtype: Link Rect: 406, 235, 517, 242 Annotation: Subtype: Link Rect: 406, 227, 515, 234 Annotation: Subtype: Link Rect: 406, 219, 466, 226 Annotation: Subtype: Link Rect: 406, 202, 540, 209 Annotation: Subtype: Link Rect: 406, 194, 542, 201 Annotation: Subtype: Link Rect: 406, 186, 544, 193 Annotation: Subtype: Link Rect: 406, 178, 534, 185 Annotation: Subtype: Link Rect: 406, 170, 544, 177 Annotation: Subtype: Link Rect: 406, 162, 541, 169 Annotation: Subtype: Link Rect: 406, 154, 468, 161 Annotation: Subtype: Link Rect: 406, 137, 530, 144 Annotation: Subtype: Link Rect: 406, 129, 529, 136 Annotation: Subtype: Link Rect: 406, 121, 539, 128 Annotation: Subtype: Link Rect: 406, 113, 518, 120 Annotation: Subtype: Link Rect: 406, 105, 527, 112 Annotation: Subtype: Link Rect: 406, 97, 524, 104 Annotation: Subtype: Link Rect: 406, 89, 433, 96 Annotation: Subtype: Link Rect: 406, 72, 543, 79 Annotation: Subtype: Link Rect: 406, 64, 544, 71 Annotation: Subtype: Link Rect: 406, 56, 544, 63 Annotation: Subtype: Link Rect: 406, 48, 539, 55 Page: Label: 18 Annotations: Annotation: Subtype: Link Rect: 69, 672, 202, 679 Annotation: Subtype: Link Rect: 69, 664, 137, 671 Annotation: Subtype: Link Rect: 69, 648, 208, 655 Annotation: Subtype: Link Rect: 69, 640, 183, 647 Annotation: Subtype: Link Rect: 69, 632, 206, 639 Annotation: Subtype: Link Rect: 69, 624, 197, 631 Annotation: Subtype: Link Rect: 69, 616, 193, 623 Annotation: Subtype: Link Rect: 69, 608, 194, 615 Annotation: Subtype: Link Rect: 69, 600, 126, 607 Annotation: Subtype: Link Rect: 69, 584, 206, 591 Annotation: Subtype: Link Rect: 69, 576, 203, 583 Annotation: Subtype: Link Rect: 69, 568, 208, 575 Annotation: Subtype: Link Rect: 69, 560, 185, 567 Annotation: Subtype: Link Rect: 69, 552, 194, 559 Annotation: Subtype: Link Rect: 69, 544, 204, 551 Annotation: Subtype: Link Rect: 69, 536, 163, 543 Annotation: Subtype: Link Rect: 69, 520, 199, 527 Annotation: Subtype: Link Rect: 69, 512, 208, 519 Annotation: Subtype: Link Rect: 69, 504, 194, 511 Annotation: Subtype: Link Rect: 69, 496, 176, 503 Annotation: Subtype: Link Rect: 69, 488, 172, 495 Annotation: Subtype: Link Rect: 69, 472, 202, 479 Annotation: Subtype: Link Rect: 69, 464, 190, 471 Annotation: Subtype: Link Rect: 69, 456, 193, 463 Annotation: Subtype: Link Rect: 69, 448, 208, 455 Annotation: Subtype: Link Rect: 69, 440, 199, 447 Annotation: Subtype: Link Rect: 69, 432, 196, 439 Annotation: Subtype: Link Rect: 69, 424, 89, 431 Annotation: Subtype: Link Rect: 69, 408, 208, 415 Annotation: Subtype: Link Rect: 69, 400, 175, 407 Annotation: Subtype: Link Rect: 69, 392, 186, 399 Annotation: Subtype: Link Rect: 69, 384, 190, 391 Annotation: Subtype: Link Rect: 69, 376, 195, 383 Annotation: Subtype: Link Rect: 69, 368, 198, 375 Annotation: Subtype: Link Rect: 69, 360, 93, 367 Annotation: Subtype: Link Rect: 69, 344, 208, 351 Annotation: Subtype: Link Rect: 69, 336, 180, 343 Annotation: Subtype: Link Rect: 69, 328, 178, 335 Annotation: Subtype: Link Rect: 69, 320, 208, 327 Annotation: Subtype: Link Rect: 69, 312, 204, 319 Annotation: Subtype: Link Rect: 69, 305, 96, 311 Annotation: Subtype: Link Rect: 69, 288, 208, 295 Annotation: Subtype: Link Rect: 69, 280, 196, 287 Annotation: Subtype: Link Rect: 69, 272, 183, 279 Annotation: Subtype: Link Rect: 69, 264, 203, 271 Annotation: Subtype: Link Rect: 69, 256, 114, 263 Annotation: Subtype: Link Rect: 69, 240, 206, 247 Annotation: Subtype: Link Rect: 69, 232, 208, 239 Annotation: Subtype: Link Rect: 69, 224, 187, 231 Annotation: Subtype: Link Rect: 69, 216, 179, 223 Annotation: Subtype: Link Rect: 69, 200, 201, 207 Annotation: Subtype: Link Rect: 69, 192, 203, 199 Annotation: Subtype: Link Rect: 69, 184, 195, 191 Annotation: Subtype: Link Rect: 69, 176, 207, 183 Annotation: Subtype: Link Rect: 69, 169, 180, 175 Annotation: Subtype: Link Rect: 69, 161, 156, 167 Annotation: Subtype: Link Rect: 69, 144, 208, 151 Annotation: Subtype: Link Rect: 69, 136, 208, 143 Annotation: Subtype: Link Rect: 69, 128, 208, 135 Annotation: Subtype: Link Rect: 69, 120, 150, 127 Annotation: Subtype: Link Rect: 69, 104, 195, 111 Annotation: Subtype: Link Rect: 69, 96, 199, 103 Annotation: Subtype: Link Rect: 69, 88, 196, 95 Annotation: Subtype: Link Rect: 69, 81, 179, 87 Annotation: Subtype: Link Rect: 69, 64, 201, 71 Annotation: Subtype: Link Rect: 69, 56, 194, 63 Annotation: Subtype: Link Rect: 69, 48, 164, 55 Annotation: Subtype: Link Rect: 238, 672, 328, 679 Annotation: Subtype: Link Rect: 238, 664, 363, 671 Annotation: Subtype: Link Rect: 238, 656, 370, 663 Annotation: Subtype: Link Rect: 238, 648, 328, 655 Annotation: Subtype: Link Rect: 238, 632, 366, 639 Annotation: Subtype: Link Rect: 238, 624, 375, 631 Annotation: Subtype: Link Rect: 238, 616, 367, 623 Annotation: Subtype: Link Rect: 238, 608, 363, 615 Annotation: Subtype: Link Rect: 238, 600, 359, 607 Annotation: Subtype: Link Rect: 238, 592, 366, 599 Annotation: Subtype: Link Rect: 238, 576, 359, 583 Annotation: Subtype: Link Rect: 238, 568, 376, 575 Annotation: Subtype: Link Rect: 238, 560, 347, 567 Annotation: Subtype: Link Rect: 238, 552, 360, 559 Annotation: Subtype: Link Rect: 238, 544, 363, 551 Annotation: Subtype: Link Rect: 238, 536, 364, 543 Annotation: Subtype: Link Rect: 238, 528, 374, 535 Annotation: Subtype: Link Rect: 238, 520, 374, 527 Annotation: Subtype: Link Rect: 238, 512, 272, 519 Annotation: Subtype: Link Rect: 238, 496, 375, 503 Annotation: Subtype: Link Rect: 238, 488, 376, 495 Annotation: Subtype: Link Rect: 238, 480, 374, 487 Annotation: Subtype: Link Rect: 238, 472, 363, 479 Annotation: Subtype: Link Rect: 238, 464, 371, 471 Annotation: Subtype: Link Rect: 238, 456, 287, 463 Annotation: Subtype: Link Rect: 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Subtype: Link Rect: 238, 256, 355, 263 Annotation: Subtype: Link Rect: 238, 248, 317, 255 Annotation: Subtype: Link Rect: 238, 232, 363, 239 Annotation: Subtype: Link Rect: 238, 224, 371, 231 Annotation: Subtype: Link Rect: 238, 216, 376, 223 Annotation: Subtype: Link Rect: 238, 208, 374, 215 Annotation: Subtype: Link Rect: 238, 200, 374, 207 Annotation: Subtype: Link Rect: 238, 192, 375, 199 Annotation: Subtype: Link Rect: 238, 184, 365, 191 Annotation: Subtype: Link Rect: 238, 176, 366, 183 Annotation: Subtype: Link Rect: 238, 168, 294, 175 Annotation: Subtype: Link Rect: 298, 104, 372, 111 Annotation: Subtype: Link Rect: 238, 96, 280, 103 Annotation: Subtype: Link Rect: 238, 80, 375, 87 Annotation: Subtype: Link Rect: 238, 72, 376, 79 Annotation: Subtype: Link Rect: 238, 64, 372, 71 Annotation: Subtype: Link Rect: 238, 56, 372, 63 Annotation: Subtype: Link Rect: 238, 48, 340, 55 Annotation: Subtype: Link Rect: 406, 672, 544, 679 Annotation: Subtype: Link Rect: 406, 664, 542, 671 Annotation: Subtype: Link Rect: 406, 656, 542, 663 Annotation: Subtype: Link Rect: 406, 648, 544, 655 Annotation: Subtype: Link Rect: 406, 640, 524, 647 Annotation: Subtype: Link Rect: 406, 632, 531, 639 Annotation: Subtype: Link Rect: 406, 624, 544, 631 Annotation: Subtype: Link Rect: 406, 616, 474, 623 Annotation: Subtype: Link Rect: 406, 599, 531, 606 Annotation: Subtype: Link Rect: 406, 591, 538, 598 Annotation: Subtype: Link Rect: 406, 583, 523, 590 Annotation: Subtype: Link Rect: 406, 566, 535, 573 Annotation: Subtype: Link Rect: 406, 559, 537, 566 Annotation: Subtype: Link Rect: 406, 551, 540, 558 Annotation: Subtype: Link Rect: 406, 543, 544, 550 Annotation: Subtype: Link Rect: 406, 535, 533, 542 Annotation: Subtype: Link Rect: 406, 527, 529, 534 Annotation: Subtype: Link Rect: 406, 510, 543, 517 Annotation: Subtype: Link Rect: 406, 502, 538, 509 Annotation: Subtype: Link Rect: 406, 494, 521, 501 Annotation: Subtype: Link Rect: 406, 486, 537, 493 Annotation: Subtype: Link Rect: 406, 478, 535, 485 Annotation: Subtype: Link Rect: 406, 470, 525, 477 Annotation: Subtype: Link Rect: 406, 453, 525, 460 Annotation: Subtype: Link Rect: 406, 445, 517, 452 Annotation: Subtype: Link Rect: 406, 437, 536, 444 Annotation: Subtype: Link Rect: 406, 429, 530, 436 Annotation: Subtype: Link Rect: 406, 421, 523, 428 Annotation: Subtype: Link Rect: 406, 413, 519, 420 Annotation: Subtype: Link Rect: 406, 405, 472, 412 Annotation: Subtype: Link Rect: 406, 388, 534, 395 Annotation: Subtype: Link Rect: 406, 380, 535, 387 Annotation: Subtype: Link Rect: 406, 372, 499, 379 Annotation: Subtype: Link Rect: 406, 364, 505, 371 Annotation: Subtype: Link Rect: 406, 356, 544, 363 Annotation: Subtype: Link Rect: 406, 348, 477, 355 Annotation: Subtype: Link Rect: 406, 331, 544, 338 Annotation: Subtype: Link Rect: 406, 323, 531, 330 Annotation: Subtype: Link Rect: 406, 315, 490, 322 Annotation: Subtype: Link Rect: 406, 307, 518, 314 Annotation: Subtype: Link Rect: 406, 300, 544, 306 Annotation: 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