TYPE Editorial PUBLISHED 05 May 2023 DOI 10.3389/fvets.2023.1200687 Editorial: Feline tumors of OPEN ACCESS nervous system EDITED BY Andrea Tipold, University of Veterinary Medicine Maria Teresa Mandara1* and Martí Pumarola2 Hannover, Germany 1 Department of Veterinary Medicine, University of Perugia, Perugia, Italy, 2 Department of Animal REVIEWED BY Medicine and Surgery, Universitat Autònoma de Barcelona, Barcelona, Spain Marco Rosati, AstraZeneca, United Kingdom Kristel Kegler, KEYWORDS University of Helsinki, Finland *CORRESPONDENCE cat, embryonal tumor, lymphoma, magnetic resonance, nervous system, schwannoma, Maria Teresa Mandara immunophenotype mandara@unipg.it RECEIVED 05 April 2023 ACCEPTED 19 April 2023 PUBLISHED 05 May 2023 CITATION Editorial on the Research Topic Mandara MT and Pumarola M (2023) Editorial: Feline tumors of nervous system Feline tumors of nervous system. Front. Vet. Sci. 10:1200687. doi: 10.3389/fvets.2023.1200687 COPYRIGHT Cats and dogs share human environments and habits which in the last decades have © 2023 Mandara and Pumarola. This is an extended life expectancy in pets as in man, and they will do more in the next (1). This is open-access article distributed under the terms why we have no doubts to assess that the cat develops tumors with an incidence similar of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction to the dog, except for species-related predisposition or viral oncogenetic infections. If this in other forums is permitted, provided the assumption is correct and probably no far from the true also for tumors of the nervous original author(s) and the copyright owner(s) system, a large number of nervous system tumors still escape from specialist investigations, are credited and that the original publication in this journal is cited, in accordance with diagnosis, therapeutic approaches and, finally, from studies. Considering the number of accepted academic practice. No use, papers published about feline tumors of nervous system in 2022, in PubMed website we find distribution or reproduction is permitted which only nine papers vs. more than 30 papers for the dog. Additionally, more difficult is to detect does not comply with these terms. wide case series studies also for tumors with high incidence in this species, as it is lymphoma. Based on these premises, in this Research Topic we wanted to promote and collect researches on this subject, and the obtained results are consistent with the aim enough to be proud to have contributed by increasing the literature on feline tumors of the nervous system of about 50% for the last year. This Research Topic includes two case reports and two original researches. The high- quality description and the originality of the case reports confirm how much medicine science and specifically feline medicine need them to add details and information in a broader context or to create a new context of focus. I owe it to Dr. Robert J. Higgins of UC of Davis in California (USA), who left us just over a year ago, to have taught us, when we were young people entering the world of research, to not neglect the value of case reports since, as he said, “their importance in knowledge advancement is all the more recognized, the less we know about.” Contrarily to the Editorial policy of many scientific journals, we are also pleased that Frontiers included Case Reports. That’s how today we know that the cat can develop neuroblastoma-like schwannoma and Embryonal Tumor with Abundant Neuropil and True Rosettes (ETANTR), thanks to detailed histological descriptions, in the first case also supported by electron microscopy analysis, and wide immunohistochemistry investigations in both. In the paper of Chen et al. the identification of pseudo-Homer-Wright rosettes characterizing the neuroblastoma- like schwannoma is really an intriguing issue. In this study negative immunolabelling for synaptophysin definitely excluded typical figures of neuroblastoma, while periaxin (2–4) and SOX-10 (5) have proven their selves as useful markers to identify the Schwann cells in the cat, further supported by strong reaction to laminin, in the controversial field of differential diagnoses to peripheral nerve sheath tumors. However, if Mahjoub et al. (6) Frontiers in Veterinary Science 01 frontiersin.org Mandara and Pumarola 10.3389/fvets.2023.1200687 assumed the pseudo-rosette pattern should be distinguished from nervous system also as a primary neoplastic disease and the typical Verocay bodies based on different arrangement of the neoplastic involvement of the optic chiasm in the cranial cavity. In the Schwann cells (horizontal rows vs. pseudo-circular alignment of second work related with feline lymphoma affecting the spinal palisaded nuclei), we think that this difference does not definitely cord (Lorenzo et al.) it is worth appreciating the collaborative support they really represent two different morphological patterns, effort among clinic, imaging, surgery, and neuropathology made although the former is collagen-rich, the latter no. Therefore, to add more information about the most common spinal cord further studies on this morphological variant are welcome also to tumor in this species. Collecting data in all these fields from define its potential biological meaning in the tumor behavior. each case is not always an easy task. Combining localization of Again, human neuropathology shows us many histological tumors, clinical findings, cerebrospinal fluid analysis, magnetic variants of tumors of the nervous system which, far from having resonance imaging characteristics and their possible correlations to simply be assumed in veterinary classification, represent a with histopathological findings, especially for the presence of continuous pressure for comparative and behavioral studies in necrosis, have provided useful markers for both final diagnosis and veterinary neuropathology. Embryonal Tumor with Multilayered prognosis of the cases. Rosettes (ETMR) is a clear example of this, encouraging Upon completion of this editorial project, we want to us to reconsider the large group of non-cerebellar Primitive thank all the contributing authors since new interesting and Neuroectodermal Tumors in pets. The paper by Foiani et al. updated information on feline tumors of the nervous system have rises up a couple of questions: (1) based on the only case of been provided for use by scientific community and veterinary feline embryonal tumor of the central nervous system (CNS) neurologists, and their daily work progress. reported in the literature, can really this species be assumed as not predisposed to juvenile CNS tumor? (2) what should “juvenile” mean in cats? Less than 2 years or <1 year? Or Author contributions rather generically <5 years, considering five as the line beyond which the incidence of neoplastic diseases tends to increase in MM wrote the body of the editorial. MP wrote part of pets? Whatever our answers are, as from today ETANTR must comments and added references. Both authors contributed to the be included in differential diagnosis of non-cerebellar PNET in article and approved the submitted version. cats and domestic animals, and classification of CNS tumors should be updated in veterinary medicine. Of course, we are Conflict of interest long way from made diagnosis by genetic investigations as in humans, but we think that for juvenile tumors a greater effort The authors declare that the research was conducted in the may be worth making in veterinary oncology. As for the feline absence of any commercial or financial relationships that could be lymphoma (Mandara et al.), one of the most common tumors of construed as a potential conflict of interest. the nervous system, the anatomical patterns have been confirmed to be numerous, as in the past review (7), and they call for different clinical weights and approaches. Albeit a long way Publisher’s note still to go in characterizing lymphoma of the nervous system to therapeutic and prognostic purposes, the authors collected All claims expressed in this article are solely those sufficient data to strongly suggest that extra-axial lymphoma, of the authors and do not necessarily represent those of except for leptomeningeal lymphomatosis, mainly expresses B- their affiliated organizations, or those of the publisher, cell phenotype. Along with the highest surgical accessibility to the editors and the reviewers. Any product that may be extra-axial tumors, this result further supports the most favorable evaluated in this article, or claim that may be made by prognosis of this anatomical pattern compared to the intra-axial its manufacturer, is not guaranteed or endorsed by the counterpart. And remember not to overlook lymphoma of the publisher. References 1. U.S. Pet Ownership & Demographics Sourcebook. Schaumburger IL: AVMA (2012). occurring canine model of CNS neuroinflammation. PLoS ONE. (2015) 10:e0133916. doi: 10.1371/journal.pone.0133916 2. Warren AL, Miller AD, de Lahunta A, Kortz G, Summers BA. Four cases of the melanotic variant of malignant nerve sheath tumor: a rare, aggressive neoplasm 5. Higgins RJ, Bollen AW, Dickinson PJ, Sisó-Llonch S. Tumors of the nervous in young dogs with a predilection for the spinal cord. J Comp Pathol. (2020) 178:1– system. In: DJ Meuten, editor. Tumors in Domestic Animals. Hoboken, NJ: Wiley 8. doi: 10.1016/j.jcpa.2020.03.010 (2016), p. 834–91. doi: 10.1002/9781119181200.ch19 3. Spitzbarth I, Heinrich F, Herder V, Recker T, Wohlsein P, Baumgärtner 6. Mahjoub WK, Jouini R, Khanchel F, Brahim EB, Llamas-Velasco M, Helel I, et al. W. Canine central nervous system neoplasm phenotyping using tissue Neuroblastoma-like schwannoma with giant rosette: a potential diagnostic pitfall for microarray technique. Vet Pathol. (2017) 54:369–79. doi: 10.1177/030098581 hyalinizing spindle cell tumor. J Cutan Pathol. (2019) 46:234–7. doi: 10.1111/cup.13405 6688745 7. Mandara MT, Motta L, Calò P. Distribution of feline lymphoma in the central 4. Kegler K, Spitzbarth I, Imbschweiler I, Wewetzer K, Baumgärtner W, and peripheral nervous systems. Vet J. (2016) 216:109–16. doi: 10.1016/j.tvjl.2016. Seehusen F. Contribution of Schwann cells to remyelination in a naturally 07.013 Frontiers in Veterinary Science 02 frontiersin.org