d321558be1739e82cb355bc3765238c4 pmc_10209542.pdf 6f44fac0c7cbc9ac6e6083630a5675aa8cfb176d pmc_10209542.pdf f00922c9b48a068794e2eb8ab191e0a68fe2adabc83407e9f18f3ce314cd0ece pmc_10209542.pdf Title: Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning Subject: ISCIENCE, 26 (2023) 106847. doi:10.1016/j.isci.2023.106847 Author: Moisés Castellá Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri May 19 16:22:19 2023 CEST ModDate: Fri May 19 16:24:36 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 21 Encrypted: no Page size: 602.986 x 782.986 pts Page rot: 0 File size: 4770710 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AENOIC+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 962 0 AENOID+AdvPSA5BC Type 1C WinAnsi yes yes no 964 0 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edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec4.2.1' cannot be found Offset: 4742383 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 4742383 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib34' cannot be found Offset: 4742383 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib63' cannot be found Offset: 4742383 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib64' cannot be found Offset: 4742383 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 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cannot be found Offset: 4742383 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib35' cannot be found Offset: 4742383 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib25' cannot be found Offset: 4742383 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1057 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: ISCI106847_proof_v26i6.pdf Children: Item: Title: Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Evidence of browning in adipose tissue from pheochromocytoma patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Transcriptomics analysis of differentially expressed genes in adipose tissue from pheochromocytoma patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Gene expression profile associated with UCP1 expression in human adipose tissue Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Downregulation of splicing factors and splicing-related proteins in association with browning Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Method details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Splicing-driven transcript isoform expression of master regulators of browning and metabolism-related genes is altered in a ..⸩㸾൥湤潢樍㄰㌹‰扪഼㰯偡牥湴‱〳㘠〠刯乥硴‱〳㠠〠刯䑥獴⣾＀猀氀椀渀欀㔩⽐牥瘠㄰㐰‰⁒⽔楴汥⣾＀䌀攀氀氀ⴀ愀甀琀漀渀漀洀漀甀猀 栀甀洀愀渀 戀爀漀眀渀椀渀最 爀攀挀愀瀀椀琀甀氀愀琀攀猀 琀栀攀 愀氀琀攀爀攀搀 最攀渀攀 攀砀瀀爀攀猀猀椀漀渀 瀀愀琀琀攀爀渀猀 漀昀 猀瀀氀椀挀椀渀最 昀愀挀琀漀爀猀 愀渀搀 猀瀀氀椀挀椀渀最ⴀ爀攀氀愀琀攀搀  ⸀⸀ Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: Limitations of the study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Supplemental information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Declaration of interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Inclusion and diversity Destination: 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and processing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: SGBS cell culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Method details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Children: Item: Title: RNA isolation and RNA-sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Analysis of correlation with UCP1 expression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Functional enrichment analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Comparative omics analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: RT-qPCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Quantification and statistical analysis Destination: 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EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1016/j.isci.2023.106847 Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning Moisés Castellá Albert Blasco-Roset Marion Peyrou Aleix Gavaldà-Navarro Joan Villarroya Tania Quesada-López Leyre Lorente-Poch Juan Sancho Florian Szymczak Anthony Piron Sonia Rodríguez-Fernández Stefania Carobbio Albert Goday Pere Domingo Antonio Vidal-Puig Marta Giralt Décio L. Eizirik Francesc Villarroya Rubén Cereijo Biopsy sample Specialized functions of cells Transcriptomics ISCIENCE, 26 (2023) 106847. doi:10.1016/j.isci.2023.106847 The Authors journal ISCIENCE © 2023 The Authors. 2589-0042 26 6 16 June 2023 2023-06-16 106847 106847 10.1016/j.isci.2023.106847 https://doi.org/10.1016/j.isci.2023.106847 2010-04-23 true 10.1016/j.isci.2023.106847 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.isci.2023.106847 noindex true 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2023-05-19T19:52:19+05:30 2023-05-19T19:54:36+05:30 2023-05-19T19:54:36+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:f10a83d3-4769-4561-9f04-9cc7c4ed2883 uuid:dbaa028c-38eb-455c-99b9-fde55ca8beb4 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 455, 436, 505, 442 Annotation: Subtype: Link Rect: 455, 427, 500, 433 Annotation: Subtype: Link Rect: 455, 68, 520, 74 Annotation: Subtype: Link Rect: 455, 60, 503, 66 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