cf69a7c3bf3b5ee37032c0d43085b6b9 pmc_10272342.pdf a6d09efb3af544312464d7ef562d4e52567ec2aa pmc_10272342.pdf 2d2e55addb544e29dda831ccfef43c7ca5b54976eb45dd5d66b76ec74321229c pmc_10272342.pdf Title: Tele-supervised home-based transcranial alternating current stimulation (tACS) for Alzheimer's disease: a pilot study Subject: Cappon D, Fox R, den Boer T, Yu W, LaGanke N, Cattaneo G, Perellón-Alfonso R, Bartrés-Faz D, Manor B and Pascual-Leone A (2023) Tele-supervised home-based transcranial alternating current stimulation (tACS) for Alzheimer's disease: a pilot study Front. Hum. Neurosci. 17:1168673. doi: 10.3389/fnhum.2023.1168673 Keywords: Alzheimer's disease, neuromodulation, transcranial alternating current stimulation (tACS), memory, cognition, electroencephalography (EEG) Author: Davide Cappon Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.16 CreationDate: Fri May 26 12:57:54 2023 CEST ModDate: Fri May 26 13:14:25 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1713811 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MERGRC+MinionPro-Regular Type 1 Custom yes yes no 27 0 OMDZWW+MuseoSans-700 Type 1 Custom yes yes no 28 0 NJZYXG+MuseoSans-300 Type 1 Custom yes yes no 29 0 WFZHCK+MuseoSans-300Italic Type 1 Custom yes yes no 34 0 HCZEMZ+MuseoSans-500 Type 1 Custom yes yes no 35 0 VPGQTI+MTSYN Type 1 Builtin yes yes no 46 0 YAGRLE+MTGU Type 1 Builtin yes yes no 139 0 BZRHWK+MinionPro-Bold Type 1 Custom yes yes no 190 0 FLSVKK+MinionPro-It Type 1 Custom yes yes no 521 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-05 02:29:23 CEST RepresentationInformation: pmc_10272342.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-27 02:24:10 CEST Size: 1713811 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 749 FreeObjects: 3 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Tele-supervised home-based transcranial alternating current stimulation (tACS) for Alzheimer's disease: a pilot study Children: Item: Title: Introduction Item: Title: Materials and methods Children: Item: Title: Participants Item: Title: Study design Item: Title: Study procedures Item: Title: Optimized tACS current flow modeling to target the left angular gyrus Item: Title: Home-based study companion-led tACS administration Item: Title: Study outcomes Children: Item: Title: Safety Children: Item: Title: Side effects questionnaire and adverse events Item: Title: Feasibility Children: Item: Title: Adherence and compliance Item: Title: Clinical outcomes Item: Title: Montreal cognitive assessment (MoCA) Item: Title: Memory Index Score (MIS) Item: Title: EEG recording and analysis Item: Title: Results Children: Item: Title: Safety Children: Item: Title: Side effects questionnaire and adverse events Item: Title: Feasibility Children: Item: Title: Adherence Item: Title: Cognitive outcomes Children: Item: Title: Memory Index Score (MIS) Item: Title: Montreal Cognitive Assessment (MoCA) Item: Title: Neurophysiological outcome Children: Item: Title: EEG resting-state Item: Title: Discussion Item: Title: Conclusion Item: Title: Data availability statement Item: Title: Ethics statement Item: Title: Author contributions Item: Title: Funding Item: Title: Conflict of interest Item: Title: Publisher's note Item: Title: References Info: Title: Tele-supervised home-based transcranial alternating current stimulation (tACS) for Alzheimer's disease: a pilot study Author: Davide Cappon Subject: Cappon D, Fox R, den Boer T, Yu W, LaGanke N, Cattaneo G, Perellón-Alfonso R, Bartrés-Faz D, Manor B and Pascual-Leone A (2023) Tele-supervised home-based transcranial alternating current stimulation (tACS) for Alzheimer's disease: a pilot study Front. Hum. Neurosci. 17:1168673. doi: 10.3389/fnhum.2023.1168673 Keywords: Alzheimer's disease, neuromodulation, transcranial alternating current stimulation (tACS), memory, cognition, electroencephalography (EEG) Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.16 CreationDate: Fri May 26 13:27:54 CEST 2023 ModDate: Fri May 26 13:44:25 CEST 2023 ID: 0xae9b769b7ed6bd3736e23c8d1a753091, 0xb447b0b789194b45a4033bdb92a3e6b1 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: WFZHCK+MuseoSans-300Italic FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: WFZHCK+MuseoSans-300Italic Flags: Symbolic FontBBox: -245, -210, 1030, 883 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: HCZEMZ+MuseoSans-500 FontSubset: true FirstChar: 3 LastChar: 243 FontDescriptor: FontName: HCZEMZ+MuseoSans-500 Flags: Symbolic FontBBox: -121, -210, 1088, 892 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FLSVKK+MinionPro-It FontSubset: true FirstChar: 2 LastChar: 233 FontDescriptor: FontName: FLSVKK+MinionPro-It Flags: Symbolic FontBBox: -201, -360, 1684, 919 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: MERGRC+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: MERGRC+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: YAGRLE+MTGU FontSubset: true FirstChar: 43 LastChar: 98 FontDescriptor: FontName: YAGRLE+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true Font: BaseFont: OMDZWW+MuseoSans-700 FontSubset: true FirstChar: 39 LastChar: 122 FontDescriptor: FontName: OMDZWW+MuseoSans-700 Flags: Symbolic FontBBox: -125, -210, 1126, 902 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: NJZYXG+MuseoSans-300 FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: NJZYXG+MuseoSans-300 Flags: Symbolic FontBBox: -118, -210, 1088, 883 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VPGQTI+MTSYN FontSubset: true FirstChar: 0 LastChar: 13 FontDescriptor: FontName: VPGQTI+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: BZRHWK+MinionPro-Bold FontSubset: true FirstChar: 49 LastChar: 117 FontDescriptor: FontName: BZRHWK+MinionPro-Bold Flags: Symbolic FontBBox: -318, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true XMP: Alzheimer's disease, neuromodulation, transcranial alternating current stimulation (tACS), memory, cognition, electroencephalography (EEG) pdfTeX-1.40.16 1.5 True https://www.frontiersin.org/legal/copyright-statement application/pdf fnhum-17-1168673.tex Tele-supervised home-based transcranial alternating current stimulation (tACS) for Alzheimer's disease: a pilot study Cappon D, Fox R, den Boer T, Yu W, LaGanke N, Cattaneo G, Perellón-Alfonso R, Bartrés-Faz D, Manor B and Pascual-Leone A (2023) Tele-supervised home-based transcranial alternating current stimulation (tACS) for Alzheimer's disease: a pilot study Front. Hum. Neurosci. 17:1168673. doi: 10.3389/fnhum.2023.1168673 Copyright © 2023 Cappon, Fox, den Boer, Yu, LaGanke, Cattaneo, Perellón-Alfonso, Bartrés-Faz, Manor and Pascual-Leone. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Davide Cappon Rachel Fox Tim den Boer Wanting Yu Nicole LaGanke Gabriele Cattaneo Ruben Perellón-Alfonso David Bartrés-Faz Brad Manor Alvaro Pascual-Leone 2023-05-26T16:27:54+05:30 Alzheimer's disease neuromodulation transcranial alternating current stimulation (tACS) memory cognition electroencephalography (EEG) 2023-05-26T16:27:54+05:30 2023-05-26T16:44:25+05:30 2023-05-26T16:44:25+05:30 LaTeX with hyperref package uuid:8dce41d7-a39b-4bbb-bb6c-e462b6c9bbb1 uuid:b5feb53c-eead-4d9f-a7d3-db23f910e8ea Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 48, 791, 274, 807 Annotation: Subtype: Link Rect: 433, 799, 496, 807 Annotation: Subtype: Link Rect: 433, 790, 520, 798 Annotation: Subtype: Link Rect: 433, 779, 550, 789 Annotation: Subtype: Link Rect: 48, 704, 126, 721 Annotation: Subtype: Link Rect: 62, 442, 160, 450 Annotation: Subtype: Link Rect: 48, 384, 76, 391 Annotation: Subtype: Link Rect: 76, 384, 112, 391 Annotation: Subtype: Link Rect: 112, 384, 148, 391 Annotation: Subtype: Link Rect: 148, 384, 174, 391 Annotation: Subtype: Link Rect: 48, 373, 75, 382 Annotation: Subtype: Link Rect: 213, 625, 546, 722 Annotation: Subtype: Link Rect: 48, 33, 159, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 447, 799, 546, 807 Annotation: Subtype: Link Rect: 338, 602, 546, 613 Annotation: Subtype: Link Rect: 206, 589, 373, 600 Annotation: Subtype: Link Rect: 247, 425, 291, 436 ActionDest: 509 Annotation: Subtype: Link Rect: 48, 413, 92, 424 ActionDest: 509 Annotation: Subtype: Link Rect: 95, 413, 114, 424 ActionDest: 509 Annotation: Subtype: Link Rect: 117, 413, 220, 424 ActionDest: 556 Annotation: Subtype: Link Rect: 223, 413, 242, 424 ActionDest: 556 Annotation: Subtype: Link Rect: 84, 365, 127, 376 ActionDest: 509 Annotation: Subtype: Link Rect: 129, 365, 148, 376 ActionDest: 509 Annotation: Subtype: Link Rect: 150, 365, 205, 376 ActionDest: 509 Annotation: Subtype: Link Rect: 207, 365, 226, 376 ActionDest: 509 Annotation: Subtype: Link Rect: 51, 329, 115, 340 ActionDest: 509 Annotation: Subtype: Link Rect: 121, 329, 140, 340 ActionDest: 509 Annotation: Subtype: Link Rect: 146, 329, 212, 340 ActionDest: 556 Annotation: Subtype: Link Rect: 217, 329, 237, 340 ActionDest: 556 Annotation: Subtype: Link Rect: 159, 305, 217, 316 ActionDest: 509 Annotation: Subtype: Link Rect: 224, 305, 243, 316 ActionDest: 509 Annotation: Subtype: Link Rect: 51, 233, 98, 244 ActionDest: 509 Annotation: Subtype: Link Rect: 99, 233, 119, 244 ActionDest: 509 Annotation: Subtype: Link Rect: 121, 233, 171, 244 ActionDest: 556 Annotation: Subtype: Link Rect: 173, 233, 192, 244 ActionDest: 556 Annotation: Subtype: Link Rect: 194, 233, 245, 244 ActionDest: 509 Annotation: Subtype: Link Rect: 247, 233, 266, 244 ActionDest: 509 Annotation: Subtype: Link Rect: 268, 233, 291, 244 ActionDest: 556 Annotation: Subtype: Link Rect: 48, 221, 92, 232 ActionDest: 556 Annotation: Subtype: Link Rect: 96, 221, 115, 232 ActionDest: 556 Annotation: Subtype: Link Rect: 119, 221, 141, 232 ActionDest: 556 Annotation: Subtype: Link Rect: 145, 221, 164, 232 ActionDest: 556 Annotation: Subtype: Link Rect: 170, 150, 227, 161 ActionDest: 509 Annotation: Subtype: Link Rect: 231, 150, 250, 161 ActionDest: 509 Annotation: Subtype: Link Rect: 254, 150, 291, 161 ActionDest: 509 Annotation: Subtype: Link Rect: 48, 139, 69, 149 ActionDest: 509 Annotation: Subtype: Link Rect: 73, 139, 93, 149 ActionDest: 509 Annotation: Subtype: Link Rect: 97, 139, 140, 149 ActionDest: 509 Annotation: Subtype: Link Rect: 145, 139, 164, 149 ActionDest: 509 Annotation: Subtype: Link Rect: 169, 139, 228, 149 ActionDest: 556 Annotation: Subtype: Link Rect: 233, 139, 252, 149 ActionDest: 556 Annotation: Subtype: Link Rect: 190, 102, 222, 113 ActionDest: 556 Annotation: Subtype: Link Rect: 224, 102, 244, 113 ActionDest: 556 Annotation: Subtype: Link Rect: 246, 102, 291, 113 ActionDest: 509 Annotation: Subtype: Link Rect: 48, 91, 67, 101 ActionDest: 509 Annotation: Subtype: Link Rect: 69, 91, 89, 101 ActionDest: 509 Annotation: Subtype: Link Rect: 91, 91, 163, 101 ActionDest: 556 Annotation: Subtype: Link Rect: 166, 91, 185, 101 ActionDest: 556 Annotation: Subtype: Link Rect: 306, 450, 356, 460 ActionDest: 556 Annotation: Subtype: Link Rect: 360, 450, 379, 460 ActionDest: 556 Annotation: Subtype: Link Rect: 384, 450, 452, 460 ActionDest: 509 Annotation: Subtype: Link Rect: 456, 450, 476, 460 ActionDest: 509 Annotation: Subtype: Link Rect: 480, 450, 544, 460 ActionDest: 509 Annotation: Subtype: Link Rect: 303, 437, 322, 448 ActionDest: 509 Annotation: Subtype: Link Rect: 325, 437, 375, 448 ActionDest: 509 Annotation: Subtype: Link Rect: 378, 437, 397, 448 ActionDest: 509 Annotation: Subtype: Link Rect: 399, 437, 419, 448 ActionDest: 509 Annotation: Subtype: Link Rect: 496, 399, 544, 409 ActionDest: 509 Annotation: Subtype: Link Rect: 303, 387, 322, 397 ActionDest: 509 Annotation: Subtype: Link Rect: 324, 387, 361, 397 ActionDest: 509 Annotation: Subtype: Link Rect: 363, 387, 382, 397 ActionDest: 509 Annotation: Subtype: Link Rect: 385, 387, 433, 397 ActionDest: 509 Annotation: Subtype: Link Rect: 435, 387, 455, 397 ActionDest: 509 Annotation: Subtype: Link Rect: 457, 387, 497, 397 ActionDest: 556 Annotation: Subtype: Link Rect: 499, 387, 519, 397 ActionDest: 556 Annotation: Subtype: Link Rect: 395, 207, 444, 218 ActionDest: 509 Annotation: Subtype: Link Rect: 446, 207, 465, 218 ActionDest: 509 Annotation: Subtype: Link Rect: 48, 33, 159, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 447, 799, 546, 807 Annotation: Subtype: Link Rect: 97, 628, 127, 639 ActionDest: 181 Annotation: Subtype: Link Rect: 313, 745, 341, 753 ActionDest: 181 Annotation: Subtype: Link Rect: 389, 636, 424, 646 ActionDest: 209 Annotation: Subtype: Link Rect: 48, 33, 159, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 447, 799, 546, 807 Annotation: Subtype: Link Rect: 77, 427, 138, 438 Annotation: Subtype: Link Rect: 398, 379, 448, 391 ActionDest: 556 Annotation: Subtype: Link Rect: 452, 379, 472, 391 ActionDest: 556 Annotation: Subtype: Link Rect: 411, 343, 445, 354 ActionDest: 209 Annotation: Subtype: Link Rect: 455, 319, 499, 330 ActionDest: 509 Annotation: Subtype: Link Rect: 503, 319, 523, 330 ActionDest: 509 Annotation: Subtype: Link Rect: 48, 33, 159, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 447, 799, 546, 807 Annotation: Subtype: Link Rect: 51, 730, 101, 741 ActionDest: 509 Annotation: Subtype: Link Rect: 103, 730, 122, 741 ActionDest: 509 Annotation: Subtype: Link Rect: 204, 471, 260, 481 ActionDest: 509 Annotation: Subtype: Link Rect: 267, 471, 286, 481 ActionDest: 509 Annotation: Subtype: Link Rect: 165, 422, 215, 433 ActionDest: 509 Annotation: Subtype: Link Rect: 218, 422, 237, 433 ActionDest: 509 Annotation: Subtype: Link Rect: 256, 422, 291, 433 ActionDest: 509 Annotation: Subtype: Link Rect: 48, 411, 67, 421 ActionDest: 509 Annotation: Subtype: Link Rect: 70, 411, 89, 421 ActionDest: 509 Annotation: Subtype: Link Rect: 222, 260, 264, 271 ActionDest: 509 Annotation: Subtype: Link Rect: 267, 260, 286, 271 ActionDest: 509 Annotation: Subtype: Link Rect: 48, 236, 78, 247 ActionDest: 331 Annotation: Subtype: Link Rect: 372, 446, 437, 457 ActionDest: 556 Annotation: Subtype: Link Rect: 440, 446, 460, 457 ActionDest: 556 Annotation: Subtype: Link Rect: 404, 411, 449, 422 ActionDest: 556 Annotation: Subtype: Link Rect: 452, 411, 471, 422 ActionDest: 556 Annotation: Subtype: Link Rect: 379, 351, 423, 362 ActionDest: 556 Annotation: Subtype: Link Rect: 425, 351, 445, 362 ActionDest: 556 Annotation: Subtype: Link Rect: 438, 316, 470, 326 ActionDest: 509 Annotation: Subtype: Link Rect: 472, 316, 492, 326 ActionDest: 509 Annotation: Subtype: Link Rect: 306, 173, 366, 184 ActionDest: 509 Annotation: Subtype: Link Rect: 368, 173, 387, 184 ActionDest: 509 Annotation: Subtype: Link Rect: 48, 33, 159, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 447, 799, 546, 807 Annotation: Subtype: Link Rect: 111, 704, 193, 715 ActionDest: 509 Annotation: Subtype: Link Rect: 197, 704, 217, 715 ActionDest: 509 Annotation: Subtype: Link Rect: 81, 641, 145, 652 ActionDest: 509 Annotation: Subtype: Link Rect: 150, 641, 170, 652 ActionDest: 509 Annotation: Subtype: Link Rect: 280, 629, 291, 640 ActionDest: 509 Annotation: Subtype: Link Rect: 48, 616, 88, 627 ActionDest: 509 Annotation: Subtype: Link Rect: 93, 616, 112, 627 ActionDest: 509 Annotation: Subtype: Link Rect: 160, 541, 202, 552 ActionDest: 556 Annotation: Subtype: Link Rect: 204, 541, 224, 552 ActionDest: 556 Annotation: Subtype: Link Rect: 51, 516, 96, 527 ActionDest: 509 Annotation: Subtype: Link Rect: 100, 516, 119, 527 ActionDest: 509 Annotation: Subtype: Link Rect: 202, 478, 262, 489 ActionDest: 556 Annotation: Subtype: Link Rect: 266, 478, 286, 489 ActionDest: 556 Annotation: Subtype: Link Rect: 117, 454, 191, 464 ActionDest: 556 Annotation: Subtype: Link Rect: 193, 454, 212, 464 ActionDest: 556 Annotation: Subtype: Link Rect: 51, 365, 103, 376 ActionDest: 509 Annotation: Subtype: Link Rect: 106, 365, 125, 376 ActionDest: 509 Annotation: Subtype: Link Rect: 51, 340, 76, 351 ActionDest: 556 Annotation: Subtype: Link Rect: 79, 340, 98, 351 ActionDest: 556 Annotation: Subtype: Link Rect: 303, 652, 332, 663 ActionDest: 331 Annotation: Subtype: Link Rect: 410, 593, 441, 603 ActionDest: 380 Annotation: Subtype: Link Rect: 303, 544, 332, 555 ActionDest: 331 Annotation: Subtype: Link Rect: 513, 375, 544, 385 ActionDest: 380 Annotation: Subtype: Link Rect: 369, 67, 391, 75 ActionDest: 380 Annotation: Subtype: Link Rect: 48, 33, 159, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 447, 799, 546, 807 Annotation: Subtype: Link Rect: 102, 600, 136, 611 ActionDest: 380 Annotation: Subtype: Link Rect: 232, 600, 272, 611 ActionDest: 419 Annotation: Subtype: Link Rect: 57, 578, 86, 586 ActionDest: 442 Annotation: Subtype: Link Rect: 124, 494, 157, 504 ActionDest: 380 Annotation: Subtype: Link Rect: 250, 494, 289, 504 ActionDest: 419 Annotation: Subtype: Link Rect: 94, 470, 122, 480 ActionDest: 442 Annotation: Subtype: Link Rect: 429, 445, 468, 455 ActionDest: 419 Annotation: Subtype: Link Rect: 515, 342, 546, 353 ActionDest: 509 Annotation: Subtype: Link Rect: 303, 331, 322, 341 ActionDest: 509 Annotation: Subtype: Link Rect: 324, 331, 343, 341 ActionDest: 509 Annotation: Subtype: Link Rect: 503, 198, 544, 209 ActionDest: 509 Annotation: Subtype: Link Rect: 303, 187, 322, 197 ActionDest: 509 Annotation: Subtype: Link Rect: 48, 33, 159, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 447, 799, 546, 807 Annotation: Subtype: Link Rect: 106, 102, 175, 113 ActionDest: 509 Annotation: Subtype: Link Rect: 178, 102, 197, 113 ActionDest: 509 Annotation: Subtype: Link Rect: 48, 33, 159, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 447, 799, 546, 807 Annotation: Subtype: Link Rect: 48, 33, 159, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Rotate: 90 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 447, 799, 546, 807 Annotation: Subtype: Link Rect: 269, 718, 291, 729 ActionDest: 509 Annotation: Subtype: Link Rect: 48, 706, 67, 717 ActionDest: 509 Annotation: Subtype: Link Rect: 70, 706, 89, 717 ActionDest: 509 Annotation: Subtype: Link Rect: 129, 622, 183, 633 ActionDest: 556 Annotation: Subtype: Link Rect: 188, 622, 207, 633 ActionDest: 556 Annotation: Subtype: Link Rect: 186, 610, 241, 621 ActionDest: 556 Annotation: Subtype: Link Rect: 246, 610, 266, 621 ActionDest: 556 Annotation: Subtype: Link Rect: 48, 33, 159, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 447, 799, 546, 807 Annotation: Subtype: Link Rect: 210, 507, 291, 516 Annotation: Subtype: Link Rect: 57, 501, 68, 507 Annotation: Subtype: Link Rect: 207, 471, 291, 480 Annotation: Subtype: Link Rect: 57, 465, 66, 471 Annotation: Subtype: Link Rect: 230, 412, 291, 421 Annotation: Subtype: Link Rect: 57, 406, 84, 412 Annotation: Subtype: Link Rect: 154, 385, 245, 393 Annotation: Subtype: Link Rect: 127, 348, 214, 357 Annotation: Subtype: Link Rect: 49, 313, 149, 321 Annotation: Subtype: Link Rect: 239, 285, 291, 294 Annotation: Subtype: Link Rect: 57, 278, 84, 285 Annotation: Subtype: Link Rect: 253, 249, 291, 258 Annotation: Subtype: Link Rect: 57, 243, 79, 249 Annotation: Subtype: Link Rect: 166, 212, 276, 221 Annotation: Subtype: Link Rect: 117, 192, 197, 201 Annotation: Subtype: Link Rect: 236, 163, 291, 172 Annotation: Subtype: Link Rect: 57, 157, 86, 163 Annotation: Subtype: Link Rect: 238, 127, 291, 136 Annotation: Subtype: Link Rect: 57, 121, 84, 128 Annotation: Subtype: Link Rect: 159, 91, 244, 100 Annotation: Subtype: Link Rect: 252, 63, 291, 72 Annotation: Subtype: Link Rect: 57, 57, 105, 64 Annotation: Subtype: Link Rect: 413, 523, 525, 532 Annotation: Subtype: Link Rect: 360, 495, 463, 504 Annotation: Subtype: Link Rect: 389, 459, 483, 468 Annotation: Subtype: Link Rect: 304, 423, 414, 432 Annotation: Subtype: Link Rect: 479, 395, 546, 404 Annotation: Subtype: Link Rect: 312, 389, 319, 396 Annotation: Subtype: Link Rect: 484, 360, 546, 368 Annotation: Subtype: Link Rect: 312, 352, 342, 360 Annotation: Subtype: Link Rect: 425, 324, 502, 332 Annotation: Subtype: Link Rect: 487, 296, 546, 304 Annotation: Subtype: Link Rect: 312, 289, 338, 296 Annotation: Subtype: Link Rect: 368, 260, 456, 269 Annotation: Subtype: Link Rect: 421, 232, 494, 241 Annotation: Subtype: Link Rect: 377, 196, 441, 205 Annotation: Subtype: Link Rect: 533, 167, 546, 176 Annotation: Subtype: Link Rect: 312, 159, 396, 168 Annotation: Subtype: Link Rect: 426, 131, 546, 140 Annotation: Subtype: Link Rect: 437, 103, 522, 112 Annotation: Subtype: Link Rect: 472, 76, 545, 84 Annotation: Subtype: Link Rect: 48, 33, 159, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 447, 799, 546, 807 Annotation: Subtype: Link Rect: 137, 755, 291, 764 Annotation: Subtype: Link Rect: 57, 747, 291, 756 Annotation: Subtype: Link Rect: 57, 739, 184, 748 Annotation: Subtype: Link Rect: 214, 710, 291, 719 Annotation: Subtype: Link Rect: 57, 704, 61, 710 Annotation: Subtype: Link Rect: 115, 674, 198, 683 Annotation: Subtype: Link Rect: 209, 646, 291, 655 Annotation: Subtype: Link Rect: 57, 640, 69, 647 Annotation: Subtype: Link Rect: 248, 610, 291, 619 Annotation: Subtype: Link Rect: 57, 602, 128, 611 Annotation: Subtype: Link Rect: 248, 575, 291, 583 Annotation: Subtype: Link Rect: 57, 567, 119, 575 Annotation: Subtype: Link Rect: 82, 539, 160, 547 Annotation: Subtype: Link Rect: 198, 518, 266, 526 Annotation: Subtype: Link Rect: 240, 496, 291, 505 Annotation: Subtype: Link Rect: 57, 490, 76, 496 Annotation: Subtype: Link Rect: 304, 747, 414, 756 Annotation: Subtype: Link Rect: 367, 727, 436, 736 Annotation: Subtype: Link Rect: 503, 699, 546, 708 Annotation: Subtype: Link Rect: 312, 693, 361, 699 Annotation: Subtype: Link Rect: 492, 671, 546, 680 Annotation: Subtype: Link Rect: 312, 665, 338, 671 Annotation: Subtype: Link Rect: 448, 635, 519, 644 Annotation: Subtype: Link Rect: 304, 607, 387, 616 Annotation: Subtype: Link Rect: 412, 580, 504, 588 Annotation: Subtype: Link Rect: 304, 545, 403, 553 Annotation: Subtype: Link Rect: 304, 504, 403, 513 Annotation: Subtype: Link Rect: 48, 33, 159, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Checksum: 749b3020 Type: CRC32 Checksum: cf69a7c3bf3b5ee37032c0d43085b6b9 Type: MD5 Checksum: a6d09efb3af544312464d7ef562d4e52567ec2aa Type: SHA-1