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EICNIP+AdvOT7d6df7ab.I+fb Type 1C Custom yes yes yes 763 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-15 03:24:37 CEST RepresentationInformation: pmc_10272729.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-14 02:39:11 CEST Size: 5052671 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 903 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: E. coli infection disrupts the epithelial barrier and activates intrinsic neurosecretory reflexes in the pig colon Destination: titlink1 Children: Item: Title: 1 Introduction Destination: flink1 Item: Title: 2 Materials and methods Destination: flink2 Children: Item: Title: 2.1 Animals Destination: slink1 Item: Title: 2.2 E. coli infection Destination: slink2 Item: Title: 2.3 Solutions and drugs Destination: slink3 Item: Title: 2.4 Measurement of electrophysiological parameters Destination: slink4 Item: Title: 2.5 Assessment of epithelial permeability Destination: slink5 Item: Title: 2.6 Mechanical experiments Destination: slink6 Item: Title: 2.7 Mast cells staining and counting Destination: slink7 Item: Title: 2.8 Data analysis and statistics Destination: slink8 Item: Title: 3 Results Destination: flink3 Children: Item: Title: 3.1 Effect of agonists and antagonists on secretory and motor function Destination: slink9 Children: Item: Title: 3.1.1 Role of muscarinic receptor on secretion and motility Destination: sslink1 Item: Title: 3.1.2 Role of VIP and forskolin on colonic secretion and motility Destination: sslink2 Item: Title: 3.1.3 Effect of nicotine on colonic secretion and motility Destination: sslink3 Item: Title: 3.1.4 Effect of serotonin on colonic secretion and motility Destination: sslink4 Item: Title: 3.1.5 Effect of histamine on colonic secretion and motility Destination: sslink5 Item: Title: 3.2 Characterization of the neurosecretory response Destination: slink10 Children: Item: Title: 3.2.1 Neural evoked mucosal chloride secretion Destination: sslink6 Item: Title: 3.3 Effect of ETEC infection on secretion and motility Destination: slink11 Children: Item: Title: 3.3.1 Effect of ETEC infection on electrophysiological parameters and epithelial permeability Destination: sslink7 Item: Title: 3.3.2 Effect of ETEC infection on neural blockade on Isc Destination: sslink8 Item: Title: 3.3.3 Effect of ETEC infection on muscular excitatory pathway Destination: sslink9 Item: Title: 3.3.4 Effect of ETEC infection on colonic MCs Destination: sslink10 Item: Title: 4 Discussion Destination: flink4 Item: Title: Data availability statement Destination: flink5 Item: Title: Ethics statement Destination: flink6 Item: Title: Author contributions Destination: flink7 Item: Title: Acknowledgments Destination: slink12 Item: Title: Conflict of interest Destination: flink8 Item: Title: Publisher’s note Destination: flink9 Item: Title: 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