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Title:          Osteogenic differentiation of adipose-derived canine mesenchymal stem cells seeded in porous calcium-phosphate scaffolds
Subject:        Introduction: Engineered bone graft substitutes are a promising alternative and supplement to autologous bone grafts as treatments for bone healing impairment.
Keywords:       canine mesenchymal stem cell, bone graft substitute, β-tricalcium phosphate, CD90, ceramic scaffold, osteogenic differentiation
Author:         David Herrera
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     Item: 
      Title: Osteogenic differentiation of adipose-derived canine mesenchymal stem cells seeded in porous calcium-phosphate scaffolds
      Children: 
       Item: 
        Title: 1. Introduction
       Item: 
        Title: 2. Materials and methods
        Children: 
         Item: 
          Title: 2.1. Experimental design summary and justification
         Item: 
          Title: 2.2. Confection of β-tricalcium phosphate 3D foams (cell carriers)
         Item: 
          Title: 2.3. Canine adipose-derived mesenchymal stem cells
         Item: 
          Title: 2.4. Implant surface cell seeding
         Item: 
          Title: 2.5. Study groups
         Item: 
          Title: 2.6. Outcome measurement and implant analysis
         Item: 
          Title: 2.6.1. Immunocytochemistry and confocal microscopy
         Item: 
          Title: 2.6.2. Ultrastructural analysis
         Item: 
          Title: 2.6.3. Digital nucleus analysis count
         Item: 
          Title: 2.6.4. Reverse transcription polymerase chain reaction
         Item: 
          Title: 2.7. Statistical and digital image analysis
       Item: 
        Title: 3. Results
        Children: 
         Item: 
          Title: 3.1. Scaffolds as carriers of multipotential stem cells
         Item: 
          Title: 3.1.1. Microscopic evaluation of scaffolds after 72 h of culture
         Item: 
          Title: 3.1.2. Digital nucleus count
         Item: 
          Title: 3.1.3. Ultrastructural evaluation of surface seeding
         Item: 
          Title: 3.2. Osteogenic β-TCP scaffolds
         Item: 
          Title: 3.2.1. Confocal microscopy analysis at 21 days of culture
         Item: 
          Title: 3.2.2. Ultrastructural evaluation of osteogenic scaffolds
         Item: 
          Title: 3.2.3. Genomic confirmation of MSC osteoblastic differentiation in 3D β-TCP scaffolds
       Item: 
        Title: 4. Discussion
       Item: 
        Title: 5. Conclusion
       Item: 
        Title: Data availability statement
       Item: 
        Title: Author contributions
       Item: 
        Title: Acknowledgments
       Item: 
        Title: Conflict of interest
       Item: 
        Title: Publisher’s note
     Item: 
      Title: References
   Info: 
    Author: David Herrera
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    Keywords: canine mesenchymal stem cell, bone graft substitute, β-tricalcium phosphate, CD90, ceramic scaffold, ost攀漀最攀渀椀挀 搀椀昀昀攀爀攀渀琀椀愀琀椀漀滾Ｉ⽍潤䑡瑥⡄㨲〲㌰㔳ㄱ㌱〱㔫〵✳〧
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