004eeb1517fe0113b29c9cdbd516f21b pmc_10299014.pdf a184dd0b85202c2ebcb3034543f95c8e94dec098 pmc_10299014.pdf 5c388a15a8372687f96469ca045d7439c847734ca9071cc255a0e11488890dff pmc_10299014.pdf Title: Pathogenic Role of IL-17 and Therapeutic Targeting of IL-17F in Psoriatic Arthritis and Spondyloarthropathies Subject: The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in host defence against microbial organisms and the development of inflammatory diseases, including psoriasis (PsO), axial spondyloarthritis (axSpA), and psoriatic arthritis (PsA). IL-17A is the signature cytokine produced by T helper 17 (Th17) cells and is considered the most biologically active form. The pathogenetic involvement of IL-17A in these conditions has been confirmed, and its blockade with biological agents has provided a highly effective therapeutical approach. IL-17F is also overexpressed in the skin and synovial tissues of patients with these diseases, and recent studies suggest its involvement in promoting inflammation and tissue damage in axSpA and PsA. The simultaneous targeting of IL-17A and IL-17F by dual inhibitors and bispecific antibodies may improve the management of Pso, PsA, and axSpA, as demonstrated in the pivotal studies of dual specific antibodies such as bimekizumab. The present review focuses on the role of IL-17F and its therapeutic blockade in axSpA and PsA. Keywords: psoriatic arthritis; axial spondyloarthritis; interleukin 17F; psoriasis; bimekizumab; sonelokimab Author: Guillermo Sánchez-Rodríguez and Lluís Puig Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Jun 21 11:49:43 2023 CEST ModDate: Wed Jun 21 11:51:32 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 824120 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SSNIUI+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 DBXHJN+VnURWPalladioL Type 1 Custom yes yes no 15 0 YIUQBD+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 KAZUWZ+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 HDSLKK+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 ASHNOE+EURM10 Type 1 Builtin yes yes no 32 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 50 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 53 0 IMEOHL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 82 0 IMEOHM+PalatinoLinotype CID TrueType Identity-H yes yes yes 85 0 IMEOHN+PalatinoLinotype TrueType WinAnsi yes yes no 91 0 IMEOHP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 94 0 IMEPNI+PalatinoLinotype TrueType MacRoman yes yes no 97 0 IMEOHL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 114 0 IMEOHM+PalatinoLinotype CID TrueType Identity-H yes yes yes 117 0 IMEOHN+PalatinoLinotype TrueType WinAnsi yes yes no 123 0 IMEOHO+PalatinoLinotype,Italic CID TrueType Identity-H yes yes yes 126 0 IMEOHP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 132 0 IMEPNI+PalatinoLinotype TrueType MacRoman yes yes no 135 0 HZASIJ+CMSY10 Type 1 Builtin yes yes no 151 0 BBETNX+PazoMath Type 1 Builtin yes yes no 168 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-02 02:33:49 CET RepresentationInformation: pmc_10299014.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-12-14 02:19:33 CET Size: 824120 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 510 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Item: Title: IL-17 Family: Synthesis, Regulation, and Receptors Destination: section.3 Item: Title: Physiological Activity of IL-17 Destination: section.4 Item: Title: IL-17: Pathogenic Role in PsA and axSpA Destination: section.5 Item: Title: IL-17F Blockade and Therapeutic Considerations Destination: section.6 Children: Item: Title: Bimekizumab Destination: subsection.6.1 Children: Item: Title: Psoriatic Arthritis Destination: subsubsection.6.1.1 Item: Title: Axial Spondyloarthritis Destination: subsubsection.6.1.2 Item: Title: Safety Destination: subsubsection.6.1.3 Item: Title: Sonelokimab Destination: subsection.6.2 Item: Title: Conclusions Destination: section.7 Item: Title: References Destination: section.8 Info: Title: Pathogenic Role of IL-17 and Therapeutic Targeting of IL-17F in Psoriatic Arthritis and Spondyloarthropathies Author: Guillermo Sánchez-Rodríguez and Lluís Puig Subject: The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in host defence against microbial organisms and the development of inflammatory diseases, including psoriasis (PsO), axial spondyloarthritis (axSpA), and psoriatic arthritis (PsA). IL-17A is the signature cytokine produced by T helper 17 (Th17) cells and is considered the most biologically active form. The pathogenetic involvement of IL-17A in these conditions has been confirmed, and its blockade with biological agents has provided a highly effective therapeutical approach. IL-17F is also overexpressed in the skin and synovial tissues of patients with these diseases, and recent studies suggest its involvement in promoting inflammation and tissue damage in axSpA and PsA. The simultaneous targeting of IL-17A and IL-17F by dual inhibitors and bispecific antibodies may improve the management of Pso, PsA, and axSpA, as demonstrated in the pivotal studies of dual specific antibodies such as bimekizumab. The present review focuses on the role of IL-17F and its therapeutic blockade in axSpA and PsA. 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