733ac5812604ff2cdbdae9113b01fb49 pmc_10299629.pdf 97aa3c5f2b82be9d1ed98a4b2718df550978b7f7 pmc_10299629.pdf f2239ec2a0f61d5591cf7205e600d2f459e3220deb76e1e0bb74021980b0fd1a pmc_10299629.pdf Title: A Personalized Approach to Determining the Caloric Needs of Children with Prader–Willi Syndrome Treated with Growth Hormone Subject: Prader–Willi Syndrome (PWS) is the most frequent cause of genetic obesity. Early reports indicate that children with PWS require 20–40% fewer calories than healthy children to maintain adequate growth. Growth hormone treatment for children with PWS, approved in 2000, affects the body composition and probably affects energy requirements. This retrospective cross-sectional study analyzed the caloric intake in children with PWS aged from 6 months to 12 years old who underwent growth hormone treatment, comparing the patients’ caloric intake calculated from parent-recorded dietary intake versus the recommended caloric intake for healthy children, taking into account the age, sex, height, weight, and physical activity. We analyzed the data from 25 patients (13 (52%) boys; mean age, 6.72 2.81 y; median age at starting growth hormone treatment, 1.4 y (IQR: 0.78–2.29); 17 (68%) normal weight and 8 (32%) overweight or obese). The mean daily energy intake was 1208 186 kcal/d, representing 96.83% 18.66 of the recommended caloric intake for healthy children. The caloric intake in children with PWS treated with growth hormone was very similar to that recommended for healthy children; thus, we should rethink the dietary recommendations for these children. Keywords: Prader–Willi syndrome; growth hormone; caloric intake; childhood; dietary record Author: Yolanda Couto-Rosende, Diana Garcia-Tirado, Mónica Palacio-Marco, Assumpta Caixàs and Raquel Corripio Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sat Jun 10 11:40:09 2023 CEST ModDate: Sat Jun 10 11:42:26 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 557798 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CVSFSJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 EBZUUU+VnURWPalladioL Type 1 Custom yes yes no 15 0 DNXEDD+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 MEBZDN+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 MQYMVW+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 RSRPIZ+CMSY10 Type 1 Builtin yes yes no 32 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 50 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 53 0 EDHILH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 91 0 EDHILI+PalatinoLinotype CID TrueType Identity-H yes yes yes 94 0 EDHILJ+PalatinoLinotype TrueType WinAnsi yes yes no 100 0 EDHILL+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 103 0 EDHJDJ+PalatinoLinotype TrueType MacRoman yes yes no 106 0 EDHILH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 120 0 EDHILI+PalatinoLinotype CID TrueType Identity-H yes yes yes 123 0 EDHILJ+PalatinoLinotype TrueType WinAnsi yes yes no 129 0 EDHILL+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 132 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-14 02:29:29 CEST RepresentationInformation: pmc_10299629.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-09-13 02:17:50 CEST Size: 557798 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 255 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Study Design and Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Measurements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Children: Item: Title: Auxological Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Daily Caloric Intake Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Physical Activity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Total Energy Expenditure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Total Energy Expenditure = Henry BMR Activity Factor Ethics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Info: Title: A Personalized Approach to Determining the Caloric Needs of Children with Prader Willi Syndrome Treated with Growth Hormone Author: Yolanda Couto-Rosende, Diana Garcia-Tirado, Mónica Palacio-Marco, Assumpta Caixàs and Raquel Corripio Subject: Prader Willi Syndrome (PWS) is the most frequent cause of genetic obesity. Early reports indicate that children with PWS require 20 40% fewer calories than healthy children to maintain adequate growth. Growth hormone treatment for children with PWS, approved in 2000, affects the body composition and probably affects energy requirements. This retrospective cross-sectional study analyzed the caloric intake in children with PWS aged from 6 months to 12 years old who underwent growth hormone treatment, comparing the patients’ caloric intake calculated from parent-recorded dietary intake versus the recommended caloric intake for healthy children, taking into account the age, sex, height, weight, and physical activity. We analyzed the data from 25 patients (13 (52%) boys; mean age, 6.72 2.81 y; median age at starting growth hormone treatment, 1.4 y (IQR: 0.78 2.29); 17 (68%) normal weight and 8 (32%) overweight or obese). The mean daily energy intake was 1208 186 kcal/d, representing 96.83% 18.66 of the recommended caloric intake for healthy children. The caloric intake in children with PWS treated with growth hormone was very similar to that recommended for healthy children; thus, we should rethink the dietary recommendations for these children. 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