0cf4822fa4e428e792009274ac476b0e pmc_10303223.pdf a83bb0937bbd71b6071a5cc4d8bafdc247da3628 pmc_10303223.pdf afbc2214238624060db03e9419a2c070e410588d3ad767c3143ebb897e630aad pmc_10303223.pdf Title: Sphingomyelin-Rich Lipid Extract Collar for Canine Atopic Dermatitis Subject: The management of canine atopic dermatitis (CAD) is complex, and it needs to be multimodal, combining topical and systemic therapies. Given that the currently available options are not always totally effective and might have some associated adverse effects, novel alternatives are needed. For this reason, a new collar for CAD was developed with 2.5% of a sphingomyelin-rich lipid extract (LE) with proven benefits for skin health. The release of the active ingredient when incorporated into the collar was tested in vitro, showing an adequate kinetic profile. Then, the efficacy and safety of the collar were assessed in 12 client-owned dogs with CAD in a pilot study. After eight weeks, the dogs experienced significant clinical improvements on the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, Pruritus Index for Canine Atopic Dermatitis (PCAD) and Pruritus Visual Analogue Scale (PVAS) scores, without any adverse effects. Additionally, further in vitro studies were performed, indicating that this LE collar should be compatible with antiparasitic collars (with deltamethrin or imidacloprid/flumethrin) if worn simultaneously. Given the observed benefits of this LE collar, combining it with other CAD therapies could potentially allow for drug sparing, reduction in adverse effects, enhanced owner compliance, and reduced treatment costs.–24pt Keywords: atopic dermatitis; sphingolipids; sphingomyelin; collar; pruritus; atopic disease; new technologies; feline dermatology Author: Sergi Segarra, David Sanmiguel, Eliseo Zuriaga, Sophie Leclerc, Jesús Cabañas, Estelle Seigneuric, Aurélie Miquel, Ana Vázquez and Lluís Ferrer Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Jun 13 09:54:20 2023 CEST ModDate: Tue Jun 13 10:03:22 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1829852 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WOSHKI+URWPalladioL-Bold Type 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(2019-04-17) LastModified: 2023-09-09 02:19:54 CEST Size: 1829852 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 380 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Lipid Extract Collar Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Evaluation of In Vitro Release Kinetic Pattern Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Efficacy and Safety in Dogs with Atopic Dermatitis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Analyses of Used Collars Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Compatibility Studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Children: Item: Title: In Vitro Release Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: In Vivo Efficacy and Safety Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Analysis of Used Collars Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Compatibility with Imidacloprid, Flumethrin and Deltamethrin Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Info: Title: Sphingomyelin-Rich Lipid Extract Collar for Canine Atopic Dermatitis Author: Sergi Segarra, David Sanmiguel, Eliseo Zuriaga, Sophie Leclerc, Jesús Cabañas, Estelle Seigneuric, Aurélie Miquel, Ana Vázquez and Lluís Ferrer Subject: The management of canine atopic dermatitis (CAD) is complex, and it needs to be multimodal, combining topical and systemic therapies. Given that the currently available options are not always totally effective and might have some associated adverse effects, novel alternatives are needed. For this reason, a new collar for CAD was developed with 2.5% of a sphingomyelin-rich lipid extract (LE) with proven benefits for skin health. The release of the active ingredient when incorporated into the collar was tested in vitro, showing an adequate kinetic profile. Then, the efficacy and safety of the collar were assessed in 12 client-owned dogs with CAD in a pilot study. After eight weeks, the dogs experienced significant clinical improvements on the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, Pruritus Index for Canine Atopic Dermatitis (PCAD) and Pruritus Visual Analogue Scale (PVAS) scores, without any adverse effects. Additionally, further in vitro studies were performed, indicating that this LE collar should be compatible with antiparasitic collars (with deltamethrin or imidacloprid/flumethrin) if worn simultaneously. Given the observed benefits of this LE collar, combining it with other CAD therapies could potentially allow for drug sparing, reduction in adverse effects, enhanced owner compliance, and reduced treatment costs. 24pt Keywords: atopic dermatitis; sphingolipids; sphingomyelin; collar; pruritus; atopic disease; new technologies; feline dermatology Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Jun 13 09:54:20 CEST 2023 ModDate: Tue Jun 13 10:03:22 CEST 2023 ID: 0x86b3af66592bf97a98f2ed34d4202ccd, 0x86b3af66592bf97a98f2ed34d4202ccd Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: LWZXXB+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 122 FontDescriptor: FontName: LWZXXB+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LWLIVD+EURM10 FontSubset: true FirstChar: 12 LastChar: 12 FontDescriptor: FontName: LWLIVD+EURM10 Flags: Symbolic FontBBox: -32, -243, 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