30abe866ca4c16c93ef7e4f6ca0315d3  pmc_10329377.pdf
a145ba3fb06a40fa669c22a9e65df0f2abb224ed  pmc_10329377.pdf
f696c05b7935c775e529fc9c5755f4a312ec7113eec90e0628dd680528ac124a  pmc_10329377.pdf

Title:           Unravelling transmission ratio distortion across the bovine genome: identification of candidate regions for reproduction defects
Subject:         BMC Genomics, https://doi.org/10.1186/s12864-023-09455-6
Keywords:        Transmission ratio distortion;Cattle Genomics;Reproduction;Mendelian inheritance;Deleterious mutations
Author:           Samir Id-Lahoucine
Creator:         Adobe InDesign 15.1 (Windows)
Producer:        Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Thu Jul  6 04:38:44 2023 CEST
ModDate:         Sat Jul  8 11:00:38 2023 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           16
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       1970710 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     42  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes     43  0
MyriadPro-It                         Type 1C           Custom           yes no  yes     44  0
MyriadPro-Regular2                   Type 1C           WinAnsi          yes no  no     530  0
MyriadPro-Light                      Type 1C           Custom           yes no  yes     66  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     45  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     46  0
LOWOBB+STIX-Regular                  Type 1C           Custom           yes yes yes     47  0
MyriadPro-SemiboldIt                 Type 1C           Custom           yes no  yes     65  0
MyriadPro-Regular3                   Type 1C           WinAnsi          yes no  yes    472  0
WarnockPro-It                        Type 1C           WinAnsi          yes no  yes    213  0
DXYROR+MTSYN3                        Type 1C           Custom           yes yes no     240  0
ZGNIFZ+MTMI2                         Type 1C           Custom           yes yes no     241  0
ZGNIFZ+WarnockPro-Regular3           Type 1C           Custom           yes yes no     242  0
JDQQPF+WarnockPro-Bold2              Type 1C           Custom           yes yes no     243  0
KIJHDH+WarnockPro-Bold               Type 1C           WinAnsi          yes yes yes    244  0
DXYROR+WarnockPro-Regular5           Type 1C           Custom           yes yes no     245  0
DXYROR+MTSYN                         Type 1C           Custom           yes yes no     246  0
JDQQPF+MTGU                          Type 1C           Custom           yes yes no     247  0
DXYROR+MTSYN4                        Type 1C           Custom           yes yes no     248  0
ZGNIFZ+MTMI4                         Type 1C           Custom           yes yes no     249  0
DXYROR+MTSYN2                        Type 1C           Custom           yes yes no     250  0
ZGNIFZ+MTMI                          Type 1C           Custom           yes yes no     251  0
ZGNIFZ+WarnockPro-Regular2           Type 1C           Custom           yes yes no     252  0
ZGNIFZ+MTMI3                         Type 1C           Custom           yes yes no     253  0
DXYROR+WarnockPro-Regular4           Type 1C           Custom           yes yes no     254  0
DXYROR+MTSYN6                        Type 1C           Custom           yes yes no     316  0
ZGNIFZ+MTMI6                         Type 1C           Custom           yes yes no     317  0
ZGNIFZ+WarnockPro-Regular7           Type 1C           Custom           yes yes no     318  0
JDQQPF+WarnockPro-Bold3              Type 1C           Custom           yes yes no     319  0
JDQQPF+MTGU2                         Type 1C           Custom           yes yes no     320  0
JDQQPF+CMEX102                       Type 1C           Custom           yes yes no     321  0
DXYROR+MTSYN5                        Type 1C           Custom           yes yes no     322  0
JDQQPF+MTGU3                         Type 1C           Custom           yes yes no     323  0
ZGNIFZ+MTMI5                         Type 1C           Custom           yes yes no     324  0
ZGNIFZ+WarnockPro-Regular6           Type 1C           Custom           yes yes no     325  0
JDQQPF+MTGU4                         Type 1C           Custom           yes yes no     326  0
DXYROR+MTSYN7                        Type 1C           Custom           yes yes no     327  0
ZGNIFZ+MTMI9                         Type 1C           Custom           yes yes no     328  0
ZGNIFZ+MTMI7                         Type 1C           Custom           yes yes no     329  0
ZGNIFZ+WarnockPro-Regular10          Type 1C           Custom           yes yes no     330  0
ZGNIFZ+WarnockPro-Regular8           Type 1C           Custom           yes yes no     331  0
DXYROR+MTSYN9                        Type 1C           Custom           yes yes no     332  0
ZGNIFZ+MTMI8                         Type 1C           Custom           yes yes no     333  0
DXYROR+MTSYN8                        Type 1C           Custom           yes yes no     334  0
JDQQPF+CMEX103                       Type 1C           Custom           yes yes no     335  0
ZGNIFZ+WarnockPro-Regular9           Type 1C           Custom           yes yes no     336  0
JDQQPF+MTGU5                         Type 1C           Custom           yes yes no     418  0
ZGNIFZ+WarnockPro-Regular11          Type 1C           Custom           yes yes no     419  0
JDQQPF+CMEX104                       Type 1C           Custom           yes yes no     420  0
ZGNIFZ+MTMI10                        Type 1C           Custom           yes yes no     421  0
DXYROR+MTSYN10                       Type 1C           Custom           yes yes no     422  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-05-15 02:42:10 CEST
 RepresentationInformation: pmc_10329377.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-05-14 02:33:18 CEST
  Size: 1970710
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 629
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Unravelling transmission ratio distortion across the bovine genome: identification of candidate regions for reproduction defects
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background 
         Item: 
          Title: Results 
         Item: 
          Title: Conclusions 
       Item: 
        Title: Background
       Item: 
        Title: Results and discussion
        Children: 
         Item: 
          Title: Prevalence of TRD across Holstein genome
          Children: 
           Item: 
            Title: Rare variants identified by TRD approach
         Item: 
          Title: Integration of TRD mapping
         Item: 
          Title: Goodness-of-fit and pattern of TRD
         Item: 
          Title: Allelic versus genotypic patterns
         Item: 
          Title: Examining the inheritance patterns of the previously described lethal haplotypes
          Children: 
           Item: 
            Title: Inheritance pattern of Holstein lethal haplotypes
           Item: 
            Title: Concordance of TRD findings across breeds
         Item: 
          Title: Novel candidate lethal allele regions
         Item: 
          Title: Functional analyses of candidate lethal allele regions
       Item: 
        Title: Conclusions
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Genotypes and trios
         Item: 
          Title: Imputation to BovineSNP50 array
          Children: 
           Item: 
            Title: Analytical models of transmission ratio distortion
         Item: 
          Title: Statistical analyses
         Item: 
          Title: Functional analyses
       Item: 
        Title: Anchor 25
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
   Info: 
    Title: Unravelling transmission ratio distortion across the bovine genome: identification of candidate regions for reproduction defects
    Author:  Samir Id-Lahoucine
    Subject: BMC Genomics, https://doi.org/10.1186/s12864-023-09455-6
    Keywords: Transmission ratio distortion;Cattle Genomics;Reproduction;Mendelian inheritance;Deleterious mutations
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Thu Jul 06 04:38:44 CEST 2023
    ModDate: Sat Jul 08 11:00:38 CEST 2023
   ID: 0x00ec5e6a317b63a819cd389948ff37b6, 0x93681e1f406f7e31ce18a0fa25391a57
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 40
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 42
      ImageHeight: 77
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 82
      ImageHeight: 84
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 75
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 40
      ImageHeight: 77
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1418
      ImageHeight: 743
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1385
      ImageHeight: 1605
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1946
      ImageHeight: 852
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1946
      ImageHeight: 1112
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MyriadPro-Regular2
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular2
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JDQQPF+MTGU5
      FontSubset: true
      FirstChar: 31
      LastChar: 32
      FontDescriptor: 
       FontName: JDQQPF+MTGU5
       Flags: Symbolic
       FontBBox: 0, -10, 387, 683
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+WarnockPro-Regular11
      FontSubset: true
      FirstChar: 20
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+WarnockPro-Regular11
       Flags: Symbolic
       FontBBox: 0, -226, 542, 710
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: JDQQPF+CMEX104
      FontSubset: true
      FirstChar: 28
      LastChar: 32
      FontDescriptor: 
       FontName: JDQQPF+CMEX104
       Flags: Symbolic
       FontBBox: 0, -1159, 413, 40
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+MTMI10
      FontSubset: true
      FirstChar: 28
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+MTMI10
       Flags: Symbolic
       FontBBox: 0, -177, 538, 676
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: DXYROR+MTSYN10
      FontSubset: true
      FirstChar: 28
      LastChar: 32
      FontDescriptor: 
       FontName: DXYROR+MTSYN10
       Flags: Symbolic
       FontBBox: 0, -156, 724, 662
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LOWOBB+STIX-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 216
      FontDescriptor: 
       FontName: LOWOBB+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: DXYROR+MTSYN6
      FontSubset: true
      FirstChar: 29
      LastChar: 32
      FontDescriptor: 
       FontName: DXYROR+MTSYN6
       Flags: Symbolic
       FontBBox: 0, -156, 724, 662
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+MTMI6
      FontSubset: true
      FirstChar: 29
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+MTMI6
       Flags: Symbolic
       FontBBox: 0, -177, 538, 676
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+WarnockPro-Regular7
      FontSubset: true
      FirstChar: 25
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+WarnockPro-Regular7
       Flags: Symbolic
       FontBBox: 0, -226, 542, 710
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: JDQQPF+WarnockPro-Bold3
      FontSubset: true
      FirstChar: 31
      LastChar: 32
      FontDescriptor: 
       FontName: JDQQPF+WarnockPro-Bold3
       Flags: Symbolic, SmallCap
       FontBBox: -6, -232, 505, 700
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: JDQQPF+MTGU2
      FontSubset: true
      FirstChar: 31
      LastChar: 32
      FontDescriptor: 
       FontName: JDQQPF+MTGU2
       Flags: Symbolic
       FontBBox: 0, -10, 387, 683
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: MyriadPro-SemiboldIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldIt
       Flags: Nonsymbolic, Italic
       FontBBox: -193, -250, 1164, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JDQQPF+CMEX102
      FontSubset: true
      FirstChar: 30
      LastChar: 32
      FontDescriptor: 
       FontName: JDQQPF+CMEX102
       Flags: Symbolic
       FontBBox: 0, -1159, 413, 40
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: DXYROR+MTSYN5
      FontSubset: true
      FirstChar: 30
      LastChar: 32
      FontDescriptor: 
       FontName: DXYROR+MTSYN5
       Flags: Symbolic
       FontBBox: 0, -156, 724, 662
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: JDQQPF+MTGU3
      FontSubset: true
      FirstChar: 31
      LastChar: 32
      FontDescriptor: 
       FontName: JDQQPF+MTGU3
       Flags: Symbolic
       FontBBox: 0, -10, 387, 683
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+MTMI5
      FontSubset: true
      FirstChar: 29
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+MTMI5
       Flags: Symbolic
       FontBBox: 0, -177, 538, 676
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+WarnockPro-Regular6
      FontSubset: true
      FirstChar: 29
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+WarnockPro-Regular6
       Flags: Symbolic
       FontBBox: 0, -226, 542, 710
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: JDQQPF+MTGU4
      FontSubset: true
      FirstChar: 31
      LastChar: 32
      FontDescriptor: 
       FontName: JDQQPF+MTGU4
       Flags: Symbolic
       FontBBox: 0, -10, 387, 683
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: DXYROR+MTSYN7
      FontSubset: true
      FirstChar: 29
      LastChar: 32
      FontDescriptor: 
       FontName: DXYROR+MTSYN7
       Flags: Symbolic
       FontBBox: 0, -156, 724, 662
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+MTMI9
      FontSubset: true
      FirstChar: 28
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+MTMI9
       Flags: Symbolic
       FontBBox: 0, -177, 538, 676
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+MTMI7
      FontSubset: true
      FirstChar: 29
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+MTMI7
       Flags: Symbolic
       FontBBox: 0, -177, 538, 676
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+WarnockPro-Regular10
      FontSubset: true
      FirstChar: 19
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+WarnockPro-Regular10
       Flags: Symbolic
       FontBBox: 0, -226, 542, 710
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+WarnockPro-Regular8
      FontSubset: true
      FirstChar: 21
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+WarnockPro-Regular8
       Flags: Symbolic
       FontBBox: 0, -226, 542, 710
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: DXYROR+MTSYN9
      FontSubset: true
      FirstChar: 28
      LastChar: 32
      FontDescriptor: 
       FontName: DXYROR+MTSYN9
       Flags: Symbolic
       FontBBox: 0, -156, 724, 662
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+MTMI8
      FontSubset: true
      FirstChar: 29
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+MTMI8
       Flags: Symbolic
       FontBBox: 0, -177, 538, 676
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: DXYROR+MTSYN8
      FontSubset: true
      FirstChar: 29
      LastChar: 32
      FontDescriptor: 
       FontName: DXYROR+MTSYN8
       Flags: Symbolic
       FontBBox: 0, -156, 724, 662
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: JDQQPF+CMEX103
      FontSubset: true
      FirstChar: 30
      LastChar: 32
      FontDescriptor: 
       FontName: JDQQPF+CMEX103
       Flags: Symbolic
       FontBBox: 0, -1159, 413, 40
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+WarnockPro-Regular9
      FontSubset: true
      FirstChar: 19
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+WarnockPro-Regular9
       Flags: Symbolic
       FontBBox: 0, -226, 542, 710
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: WarnockPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -221, -533, 1474, 950
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: DXYROR+MTSYN3
      FontSubset: true
      FirstChar: 29
      LastChar: 32
      FontDescriptor: 
       FontName: DXYROR+MTSYN3
       Flags: Symbolic
       FontBBox: 0, -156, 724, 662
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+MTMI2
      FontSubset: true
      FirstChar: 29
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+MTMI2
       Flags: Symbolic
       FontBBox: 0, -177, 538, 676
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+WarnockPro-Regular3
      FontSubset: true
      FirstChar: 19
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+WarnockPro-Regular3
       Flags: Symbolic
       FontBBox: 0, -226, 542, 710
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: JDQQPF+WarnockPro-Bold2
      FontSubset: true
      FirstChar: 31
      LastChar: 32
      FontDescriptor: 
       FontName: JDQQPF+WarnockPro-Bold2
       Flags: Symbolic, SmallCap
       FontBBox: -6, -232, 505, 700
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: KIJHDH+WarnockPro-Bold
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: KIJHDH+WarnockPro-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -183, -599, 1614, 1030
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: DXYROR+WarnockPro-Regular5
      FontSubset: true
      FirstChar: 16
      LastChar: 32
      FontDescriptor: 
       FontName: DXYROR+WarnockPro-Regular5
       Flags: Symbolic, SmallCap
       FontBBox: 0, -99, 702, 710
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: DXYROR+MTSYN
      FontSubset: true
      FirstChar: 27
      LastChar: 32
      FontDescriptor: 
       FontName: DXYROR+MTSYN
       Flags: Symbolic
       FontBBox: 0, -156, 724, 662
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: JDQQPF+MTGU
      FontSubset: true
      FirstChar: 31
      LastChar: 32
      FontDescriptor: 
       FontName: JDQQPF+MTGU
       Flags: Symbolic
       FontBBox: 0, -10, 387, 683
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: DXYROR+MTSYN4
      FontSubset: true
      FirstChar: 29
      LastChar: 32
      FontDescriptor: 
       FontName: DXYROR+MTSYN4
       Flags: Symbolic
       FontBBox: 0, -156, 724, 662
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+MTMI4
      FontSubset: true
      FirstChar: 29
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+MTMI4
       Flags: Symbolic
       FontBBox: 0, -177, 538, 676
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: DXYROR+MTSYN2
      FontSubset: true
      FirstChar: 30
      LastChar: 32
      FontDescriptor: 
       FontName: DXYROR+MTSYN2
       Flags: Symbolic
       FontBBox: 0, -156, 724, 662
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+MTMI
      FontSubset: true
      FirstChar: 29
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+MTMI
       Flags: Symbolic
       FontBBox: 0, -177, 538, 676
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+WarnockPro-Regular2
      FontSubset: true
      FirstChar: 26
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+WarnockPro-Regular2
       Flags: Symbolic
       FontBBox: 0, -226, 542, 710
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZGNIFZ+MTMI3
      FontSubset: true
      FirstChar: 29
      LastChar: 32
      FontDescriptor: 
       FontName: ZGNIFZ+MTMI3
       Flags: Symbolic
       FontBBox: 0, -177, 538, 676
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: DXYROR+WarnockPro-Regular4
      FontSubset: true
      FirstChar: 21
      LastChar: 32
      FontDescriptor: 
       FontName: DXYROR+WarnockPro-Regular4
       Flags: Symbolic, SmallCap
       FontBBox: 0, -99, 702, 710
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2023-07-06T02:38:44</xmp:CreateDate>
         <xmp:CreatorTool>Adobe InDesign 15.1 (Windows)</xmp:CreatorTool>
         <xmp:ModifyDate>2023-07-08T11:00:38+02:00</xmp:ModifyDate>
         <xmp:MetadataDate>2023-07-08T11:00:38+02:00</xmp:MetadataDate>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Keywords>Transmission ratio distortion;Cattle Genomics;Reproduction;Mendelian inheritance;Deleterious mutations</pdf:Keywords>
         <pdf:Trapped>False</pdf:Trapped>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1186/s12864-023-09455-6</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BioMed Central</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">BMC Genomics, https://doi.org/10.1186/s12864-023-09455-6</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Transmission ratio distortion</rdf:li>
               <rdf:li>Cattle Genomics</rdf:li>
               <rdf:li>Reproduction</rdf:li>
               <rdf:li>Mendelian inheritance</rdf:li>
               <rdf:li>Deleterious mutations</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Unravelling transmission ratio distortion across the bovine genome: identification of candidate regions for reproduction defects</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li> Samir Id-Lahoucine</rdf:li>
               <rdf:li> Joaquim Casellas</rdf:li>
               <rdf:li> Aroa Suárez-Vega</rdf:li>
               <rdf:li> Pablo A. S. Fonseca</rdf:li>
               <rdf:li> Flavio S. Schenkel</rdf:li>
               <rdf:li> Mehdi Sargolzaei</rdf:li>
               <rdf:li> Angela Cánovas</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1186/s12864-023-09455-6</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1186/s12864-023-09455-6</prism:url>
         <prism:doi>10.1186/s12864-023-09455-6</prism:doi>
         <prism:issn>1471-2164</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>BMC Genomics</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s12864-023-09455-6</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmpMM:DocumentID>uuid:c5a91cb9-7f21-41a8-8f35-24cb9703625c</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:2121c40f-7b59-4a01-8a99-961fb6e4729c</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:c5a91cb9-7f21-41a8-8f35-24cb9703625c</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2023-07-07T07:59:15Z</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 212, 68, 330, 60
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 486, 68, 530, 60
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 60, 276, 52
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 683, 540, 650
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 129, 655, 134, 643
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 140, 655, 145, 643
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 87, 619, 92, 607
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 242, 595, 247, 583
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 96, 583, 101, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 282, 583, 287, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 207, 547, 211, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 216, 547, 226, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 114, 463, 124, 451
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 129, 463, 138, 451
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 227, 439, 237, 427
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 128, 391, 138, 379
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 242, 307, 251, 295
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 116, 151, 126, 139
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 132, 151, 142, 139
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 136, 115, 146, 103
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 367, 535, 377, 523
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 506, 439, 516, 427
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 503, 427, 508, 415
       Flags: Print
       AppearanceDictionary: true
       Destination: 394
      Annotation: 
       Subtype: Link
       Rect: 307, 283, 317, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 307, 103, 317, 91
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 134, 584, 143, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 59, 572, 69, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 167, 332, 177, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 322, 632, 327, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 49
      Annotation: 
       Subtype: Link
       Rect: 508, 512, 513, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 394
      Annotation: 
       Subtype: Link
       Rect: 475, 416, 480, 404
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 351, 368, 361, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 179, 693, 189, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 195, 621, 205, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 249, 237, 258, 224
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 227, 81, 236, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 482, 501, 492, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 373, 453, 378, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 96
      Annotation: 
       Subtype: Link
       Rect: 415, 453, 420, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 410, 201, 420, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 425, 201, 435, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 526, 201, 536, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 304, 189, 314, 176
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 408, 189, 418, 176
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 424, 189, 434, 176
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 307, 177, 317, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 321, 165, 331, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 337, 165, 347, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 354, 141, 359, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 377, 105, 382, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 96
      Annotation: 
       Subtype: Link
       Rect: 458, 93, 463, 80
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 205, 198, 215, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 275, 174, 285, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 421, 246, 426, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 320, 210, 325, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 394
      Annotation: 
       Subtype: Link
       Rect: 330, 174, 340, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 373, 174, 383, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 388, 174, 398, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 446, 174, 456, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 461, 174, 471, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 441, 162, 451, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 388, 126, 393, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 268, 218, 273, 206
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 169, 182, 179, 170
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 96, 110, 106, 98
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 112, 110, 122, 98
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 215, 110, 224, 98
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 198, 98, 207, 86
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 220, 86, 230, 74
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 428, 230, 438, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 334, 158, 339, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 452, 158, 457, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 394
      Annotation: 
       Subtype: Link
       Rect: 442, 146, 452, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 478, 98, 483, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 364, 86, 369, 74
       Flags: Print
       AppearanceDictionary: true
       Destination: 394
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 526, 113, 536, 100
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 304, 101, 314, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 525, 101, 535, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 365, 77, 375, 64
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 261, 214, 463, 206
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 275, 621, 285, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 192, 513, 202, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 208, 513, 218, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 120, 501, 130, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 196, 477, 206, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 124, 465, 134, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 139, 465, 149, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 59, 453, 69, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 74, 453, 84, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 166, 441, 176, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 180, 441, 190, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 107, 429, 117, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 122, 429, 132, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 164, 405, 169, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 280, 405, 285, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 394
      Annotation: 
       Subtype: Link
       Rect: 198, 393, 208, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 213, 393, 223, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 275, 357, 285, 344
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 247, 333, 252, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 135, 321, 140, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 394
      Annotation: 
       Subtype: Link
       Rect: 348, 585, 358, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 363, 345, 368, 332
       Flags: Print
       AppearanceDictionary: true
       Destination: 214
      Annotation: 
       Subtype: Link
       Rect: 428, 297, 433, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 214
      Annotation: 
       Subtype: Link
       Rect: 364, 237, 369, 224
       Flags: Print
       AppearanceDictionary: true
       Destination: 214
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 200, 693, 205, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 394
      Annotation: 
       Subtype: Link
       Rect: 252, 645, 257, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 394
      Annotation: 
       Subtype: Link
       Rect: 283, 645, 288, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 394
      Annotation: 
       Subtype: Link
       Rect: 166, 537, 176, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 201, 489, 210, 476
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 216, 489, 226, 476
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 127, 453, 137, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 232, 429, 237, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 394
      Annotation: 
       Subtype: Link
       Rect: 104, 369, 109, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 132, 369, 137, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 218
      Annotation: 
       Subtype: Link
       Rect: 243, 321, 248, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 218
      Annotation: 
       Subtype: Link
       Rect: 89, 105, 99, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 308, 669, 318, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 419, 657, 429, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 308, 585, 318, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 324, 585, 335, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 401, 537, 411, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 345, 501, 355, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 473, 489, 478, 476
       Flags: Print
       AppearanceDictionary: true
       Destination: 233
      Annotation: 
       Subtype: Link
       Rect: 388, 297, 398, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 409, 225, 419, 212
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
     Thumb: true
    Page: 
     Sequence: 10
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 278, 140, 288, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 56, 128, 66, 116
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 361, 369, 366, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 305
      Annotation: 
       Subtype: Link
       Rect: 438, 177, 443, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 394
      Annotation: 
       Subtype: Link
       Rect: 372, 81, 382, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 80, 258, 90, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 94, 258, 104, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 371, 282, 381, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 507, 246, 517, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
     Thumb: true
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 59, 439, 69, 426
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 408, 243, 418, 231
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 523, 207, 533, 195
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 512, 183, 522, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 386, 123, 396, 111
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
     Thumb: true
    Page: 
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 149, 657, 159, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 438
      Annotation: 
       Subtype: Link
       Rect: 107, 561, 116, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 122, 561, 132, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 207, 376, 217, 364
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 188, 340, 198, 328
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 239, 196, 290, 184
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 184, 116, 172
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 126, 184, 136, 172
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 142, 184, 152, 172
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 139, 172, 149, 160
       Flags: Print
       AppearanceDictionary: true
       Destination: 456
      Annotation: 
       Subtype: Link
       Rect: 496, 689, 529, 681
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 304, 680, 404, 672
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 252, 252, 274, 244
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 244, 180, 233
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 386, 91, 536, 83
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 82, 377, 74
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 16
     Thumb: true
  Checksum: d46c8bae
   Type: CRC32
  Checksum: 30abe866ca4c16c93ef7e4f6ca0315d3
   Type: MD5
  Checksum: a145ba3fb06a40fa669c22a9e65df0f2abb224ed
   Type: SHA-1
  Checksum: f696c05b7935c775e529fc9c5755f4a312ec7113eec90e0628dd680528ac124a
   Type: SHA-256