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Title: 2.4 | THOP1 Simoa assay Destination: subsection..1.2.4 Item: Title: 2.5 | Statistical analysis Destination: subsection..1.2.5 Item: Title: 3 | RESULTS Destination: section..1.3 Children: Item: Title: 3.1 | THOP1 immunoassays show good analytical performance and correlated with the proteomics platform Destination: subsection..1.3.1 Item: Title: 3.2 | CSF THOP1 concentrations were highest in MCI-Ab+ and AD groups in both validation cohorts Destination: subsection..1.3.2 Item: Title: 3.3 | CSF THOP1 concentrations correlate with CSF markers reflecting total amyloid load and tau pathology Destination: subsection..1.3.3 Item: Title: 4 | DISCUSSION Destination: section..1.4 Item: Title: AUTHOR CONTRIBUTIONS Destination: section*.4 Item: Title: ACKNOWLEDGMENTS Destination: section*.6 Item: Title: CONFLICTS OF INTEREST STATEMENT Destination: section*.8 Children: Item: Title: DATA AVAILABILITY STATEMENT Destination: section*.10 Item: Title: CONSENT STATEMENT Destination: section*.12 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