2413a2befbc3c649e5f97e9f6ebfc0d1 pmc_10376071.pdf 73886f5e768880d1da933d72b35384f0ba8f3654 pmc_10376071.pdf 62a560c0a1a894df394491deb6b78a8bda723ad67a6d615b5a8dfca5709feb39 pmc_10376071.pdf Title: Reference Range of Kaolin-Activated Thromboelastography (TEG) Values in Healthy Pet Rabbits (Oryctolagus cuniculus) Subject: Thromboelastography (TEG) is a viscoelastic technique that allows the examination of both cellular and plasma protein clotting factors. Thromboelastography helps to investigate the underlying coagulopathy and to monitor therapeutic modalities. Although viscoelastic techniques have been used in human and veterinary medicine, reference ranges in pet rabbits are missing. The objective of this study is to establish the reference-range values of TEG parameters in healthy pet rabbits. 24 healthy pet rabbits of different breeds were included: 16 crossbreeds, four Californians, two lops, one lionhead, and one angora. Four rabbits were less than one year old and 20 were older than one year. Twelve rabbits were neutered females, 10 neutered males, and two were intact females. Health status was assessed through a physical examination, a complete blood work, and a coagulation profile. A TEG 5000 Thromboelastograph Hemostasis System was used with kaolin-activated citrated whole blood. All samples were analysed 30 min postextraction. The TEG reference ranges were reaction time (R) 1.4–6.9 min; clot formation time (K) 0.8–2.2 min; angle 65.8–82.2 degrees; maximal amplitude (MA) 53.7–73.5 mm; measure of clot strength/firmness (G-value) 5796.6–13,885.9 dyn/cm2; and percentage of clot lysis in 30 min (LY30%) 0–41.5%. This study provides the reference ranges of TEG in pet rabbits. Keywords: haemostatic disorder; rabbit; reference range; thromboelastography; viscoelastic method Author: Tiziana Bassan, Josep Pastor, Beatriz Agulla, Oriol Jornet and Jaume Martorell Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sun Jul 23 10:13:13 2023 CEST ModDate: Sun Jul 23 10:17:38 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 958457 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KORLVE+VnURWPalladioL Type 1 Custom yes yes no 10 0 ZXDKIP+EURM10 Type 1 Builtin yes yes no 15 0 HBCWNC+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 VZSCNK+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 OEOMAT+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 KBRCPS+URWPalladioL-BoldItal Type 1 Custom yes yes no 32 0 SZMRXJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 50 0 UWJUYN+CMSY10 Type 1 Builtin yes yes no 72 0 DCLNNA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 92 0 DCLNOB+PalatinoLinotype CID TrueType Identity-H yes yes yes 95 0 DCLNOC+PalatinoLinotype TrueType WinAnsi yes yes no 101 0 DCLNOE+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 104 0 DCLPFO+PalatinoLinotype TrueType MacRoman yes yes no 107 0 DCLNNA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 142 0 DCLNOB+PalatinoLinotype CID TrueType Identity-H yes yes yes 145 0 DCLNOC+PalatinoLinotype TrueType WinAnsi yes yes no 151 0 DCLNOE+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 154 0 DCLPDO+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 157 0 DCLPFO+PalatinoLinotype TrueType MacRoman yes yes no 160 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-06 02:27:11 CEST RepresentationInformation: pmc_10376071.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-09-02 02:20:37 CEST Size: 958457 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 344 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Animals Selected Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Sample Collection and Processing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Thromboelastography Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Info: Title: Reference Range of Kaolin-Activated Thromboelastography (TEG) Values in Healthy Pet Rabbits (Oryctolagus cuniculus) Author: Tiziana Bassan, Josep Pastor, Beatriz Agulla, Oriol Jornet and Jaume Martorell Subject: Thromboelastography (TEG) is a viscoelastic technique that allows the examination of both cellular and plasma protein clotting factors. Thromboelastography helps to investigate the underlying coagulopathy and to monitor therapeutic modalities. Although viscoelastic techniques have been used in human and veterinary medicine, reference ranges in pet rabbits are missing. The objective of this study is to establish the reference-range values of TEG parameters in healthy pet rabbits. 24 healthy pet rabbits of different breeds were included: 16 crossbreeds, four Californians, two lops, one lionhead, and one angora. Four rabbits were less than one year old and 20 were older than one year. Twelve rabbits were neutered females, 10 neutered males, and two were intact females. Health status was assessed through a physical examination, a complete blood work, and a coagulation profile. A TEG 5000 Thromboelastograph Hemostasis System was used with kaolin-activated citrated whole blood. All samples were analysed 30 min postextraction. The TEG reference ranges were reaction time (R) 1.4 6.9 min; clot formation time (K) 0.8 2.2 min; angle 65.8 82.2 degrees; maximal amplitude (MA) 53.7 73.5 mm; measure of clot strength/firmness (G-value) 5796.6 13,885.9 dyn/cm2; and percentage of clot lysis in 30 min (LY30%) 0 41.5%. This study provides the reference ranges of TEG in pet rabbits. 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