14cfeaac2c2438118b472e473e991cb8 pmc_10383788.pdf 6c118062066bae4f524ed70d15a030f0e409e939 pmc_10383788.pdf 3298c3643ccc59c3517e32b0762e4de3f03f4595c75308ab0fc178b3397575cb pmc_10383788.pdf Title: Strategies for the Preparation of Phosphorus Janus Dendrimers and Their Properties Subject: Dendrimers, being highly branched monodispersed macromolecules, predominantly exhibit identical terminal functionalities within their structural framework. Nonetheless, there are instances where the presence of two distinct surface functionalities becomes advantageous for the fulfilment of specific properties. To achieve this objective, one approach involves implementing Janus dendrimers, consisting of two dendrimeric wedges terminated by dissimilar functionalities. The prevalent method for creating these structures involves the synthesis of dendrons that possess a core functionality that complements that of a second dendron, facilitating their coupling to generate the desired dendrimers. In this comprehensive review, various techniques employed in the fabrication of phosphorus-based Janus dendrimers are elucidated, displaying the different coupling methodologies employed between the two units. The advantages of phosphorus dendrimers over classic dendrimers will be shown, as the presence of at least one phosphorus atom in each generation allows for the easy monitoring of reactions and the confirmation of purity through a simple technique such as 31P NMR, as these structures typically exhibit easily interpretable patterns. Keywords: phosphorus chemistry; Janus dendrimers; dendrons; 31P NMR spectroscopy Author: Joel Cejas-Sánchez, Anna Kajetanowicz, Karol Grela, Anne-Marie Caminade and Rosa María Sebastián Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Jul 21 13:29:23 2023 CEST ModDate: Fri Jul 21 15:35:32 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 7172958 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CYSXXM+VnURWPalladioL Type 1 Custom yes yes no 10 0 WALEFK+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 DZYPRU+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 WSLVCQ+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 SSNIUI+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 PUSVWS+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 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TrueType WinAnsi yes yes no 475 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 479 0 BCDHEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 483 0 BCDIEE+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 489 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 508 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 512 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 516 0 BCDHEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 520 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-02 02:33:31 CET RepresentationInformation: pmc_10383788.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-02-01 02:45:06 CET Size: 7172958 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 712 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Phosphorus Dendrimers Built via Vinyl/Amine Coupling Destination: section.2 Item: Title: Synthesis of Dendrimers via Staudinger Reaction Destination: section.3 Item: Title: Synthesis via Coupling of AB5 Cyclotriphosphazene Systems Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Strategies for the Preparation of Phosphorus Janus Dendrimers and Their Properties Author: Joel Cejas-Sánchez, Anna Kajetanowicz, Karol Grela, Anne-Marie Caminade and Rosa María Sebastián Subject: Dendrimers, being highly branched monodispersed macromolecules, predominantly exhibit identical terminal functionalities within their structural framework. Nonetheless, there are instances where the presence of two distinct surface functionalities becomes advantageous for the fulfilment of specific properties. To achieve this objective, one approach involves implementing Janus dendrimers, consisting of two dendrimeric wedges terminated by dissimilar functionalities. The prevalent method for creating these structures involves the synthesis of dendrons that possess a core functionality that complements that of a second dendron, facilitating their coupling to generate the desired dendrimers. In this comprehensive review, various techniques employed in the fabrication of phosphorus-based Janus dendrimers are elucidated, displaying the different coupling methodologies employed between the two units. The advantages of phosphorus dendrimers over classic dendrimers will be shown, as the presence of at least one phosphorus atom in each generation allows for the easy monitoring of reactions and the confirmation of purity through a simple technique such as 31P NMR, as these structures typically exhibit easily interpretable patterns. 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