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Title:           Systemic and functional effects of continuous azithromycin treatment in patients with severe chronic obstructive pulmonary disease and frequent exacerbations
Subject:         Background: Continuous treatment with azithromycin may lead to fewer acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but little is known of its impact on systemic and functional outcomes in real-life settings.
Author:          Ester Cuevas; Daniel Huertas; Concepción Montón; Alicia Marin; Anna Carrera-Salinas; Xavier Pomares; Marian García-Nuñez; Sara Martí; Salud Santos
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     Item: 
      Title: Systemic and functional effects of continuous azithromycin treatment in patients with severe chronic obstructive pulmonary disease and frequent exacerbations
      Children: 
       Item: 
        Title: 1. Introduction
       Item: 
        Title: 2. Methods
        Children: 
         Item: 
          Title: 2.1. Study design
         Item: 
          Title: 2.2. Patient selection
         Item: 
          Title: 2.3. Visits and follow-up
         Item: 
          Title: 2.4. Quantification of inflammatory parameters in blood and sputum
         Item: 
          Title: 2.5. Sputum collection and bacterial load detection
         Item: 
          Title: 2.6. Statistical analyzes
       Item: 
        Title: 3. Results
        Children: 
         Item: 
          Title: 3.1. Study subjects
         Item: 
          Title: 3.2. Clinical and functional effects after continuous azithromycin treatment
         Item: 
          Title: 3.3. Inflammatory changes in serum and sputum
         Item: 
          Title: 3.4. Predictors of clinical response in study participants
         Item: 
          Title: 3.5. Effect of treatment with azithromycin on COPD exacerbations
         Item: 
          Title: 3.6. Microbiological effect of continuous azithromycin treatment
       Item: 
        Title: 4. Discussion
       Item: 
        Title: Data availability statement
       Item: 
        Title: Ethics statement
       Item: 
        Title: Author contributions
       Item: 
        Title: Funding
       Item: 
        Title: Conflict of interest
       Item: 
        Title: Publisher’s note
       Item: 
        Title: Supplementary material
     Item: 
      Title: References
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    Author: Ester Cuevas; Daniel Huertas; Concepción Montón; Alicia Marin; Anna Carrera-Salinas; Xavier Pomares; Marian García-Nuñez; Sara Martí; Salud Santos
    Subject: Background: Continuous treatment with azithromycin may lead to fewer acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but little is known of its impact on systemic and functional outcomes in real-life settings.
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   Type: CRC32
  Checksum: 36ef6d63136ae0364bc511d9136d5aea
   Type: MD5
  Checksum: f96cead80c986829d0525567fdc714b77881df3b
   Type: SHA-1
  Checksum: 1e71b83d2efd87cccfa81ed10156c67e096339bca5fb8452fb11aadf46d9d9cb
   Type: SHA-256