f2b6de8f8cd27f0775a221cb9112f757 pmc_10450934.pdf b33ec60cb1ee4a3c99c43bd53a8417f21536cf2a pmc_10450934.pdf 7403b420760e449d0f93b0fbe90780b09457253d0f67af81e95ae963089ae3f5 pmc_10450934.pdf Title: Comparison of the pathological outcome and disease progression of two Mycobacterium caprae experimental challenge models in goats: endobronchial inoculation vs. intranasal nebulization Subject: Melgarejo C, Cobos A, Planas C, Fondevila J, Martı́n M, Cervera Z, Cantero G, Moll X, Espada Y, Domingo M, Vidal E and Pérez de Val B (2023) Comparison of the pathological outcome and disease progression of two Mycobacterium caprae experimental challenge models in goats: endobronchial inoculation vs. intranasal nebulization. Front. Microbiol. 14:1236834. doi: 10.3389/fmicb.2023.1236834 Keywords: tuberculosis; Mycobacterium caprae; goat; experimental infection; intranasal; endobronchial Author: Cristian Melgarejo Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Sat Aug 5 15:53:16 2023 CEST ModDate: Sat Aug 5 18:29:58 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.26 x 842.116 pts (A4) Page rot: 0 File size: 3982646 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ELUWVJ+MuseoSans-700 Type 1C Custom yes yes yes 38 0 MONCWM+MuseoSans-300 Type 1C Custom yes yes yes 41 0 YZENCD+MuseoSans-300Italic Type 1C WinAnsi yes yes no 56 0 MOPDMW+MinionPro-Regular Type 1C Custom yes yes no 59 0 WEAZWA+MuseoSans-500 Type 1C Custom yes yes yes 66 0 WVOESN+MuseoSans-500Italic Type 1C WinAnsi yes yes no 68 0 JYXRHX+MTGU Type 1C Custom yes yes no 71 0 WVOESN+MuseoSans-700Italic Type 1C WinAnsi yes yes no 73 0 GKLMFP+MinionPro-It Type 1C WinAnsi yes yes no 86 0 UZEWOG+MTSY Type 1C Custom yes yes yes 144 0 HLWIXK+MTGUB Type 1C Custom yes yes no 157 0 CVJJBP+RMTMI Type 1C Custom yes yes yes 159 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-21 02:28:49 CEST RepresentationInformation: pmc_10450934.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-09-19 02:17:06 CEST Size: 3982646 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 436 FreeObjects: 19 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Comparison of the pathological outcome and disease progression of two Mycobacterium caprae experimental challenge models in go愀琀猀㨀 攀渀搀漀戀爀漀渀挀栀椀愀氀 椀渀漀挀甀氀愀琀椀漀渀 瘀猀⸀ 椀渀琀爀愀渀愀猀愀氀 渀攀戀甀氀椀稀愀琀椀漀温㸾൥湤潢樍㘠〠潢樍㰼⽐慲敮琠㔠〠刯乥硴‷‰⁒⽄敳琯獥捴楯渮〮ㄯ䅣瑩潮⽇潔漯呩瑬攨1. Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: 1. Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: 2. Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: 2.1. Animals and experimental infections Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: 2.2. Ethics statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 2.3. Antigens and reagents Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: 2.4. Whole blood IFN-γ release assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 2.5. Antibody detection assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 2.6. Necropsy, pathological examination, and computed tomography Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 2.7. Quantification of bacterial DNA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 2.8. Data analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 3. Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Children: Item: Title: 3.1. Endobronchial challenge induced earlier and stronger immune responses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 3.2. Disease-related clinical signs appeared later in intranasally challenged goats Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 3.3. Endobronchially challenged animals showed more severe lung lesions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 3.4. Intranasal challenge caused more severe lesions in the head but less generalized TB forms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 4. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Data availability statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Ethics statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Conflict of interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Publisher's note Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Info: Title: Comparison of the pathological outcome and disease progression of two Mycobacterium caprae experimental challenge models in goats: endobronchial inoculation vs. intranasal nebulization Author: Cristian Melgarejo Subject: Melgarejo C, Cobos A, Planas C, Fondevila J, Martı́n M, Cervera Z, Cantero G, Moll X, Espada Y, Domingo M, Vidal E and Pérez 搀攀 嘀愀氀 䈀 ㈀　㈀㌀ 䌀漀洀瀀愀爀椀猀漀渀 漀昀 琀栀攀 瀀愀琀栀漀氀漀最椀挀愀氀 漀甀琀挀漀洀攀 愀渀搀 搀椀猀攀愀猀攀 瀀爀漀最爀攀猀猀椀漀渀 漀昀 琀眀漀 䴀礀挀漀戀愀挀琀攀爀椀甀洀 挀愀瀀爀愀攀 攀砀瀀攀爀椀洀攀渀琀愀氀 挀栀愀氀氀攀湜ഀ最攀 洀漀搀攀氀猀 椀渀 最漀愀琀猀㨀 攀渀搀漀戀爀漀渀挀栀椀愀氀 椀渀漀挀甀氀愀琀椀漀渀 瘀猀⸀ 椀渀琀爀愀渀愀猀愀氀 渀攀戀甀氀椀稀愀琀椀漀渀⸀ 䘀爀漀渀琀⸀ 䴀椀挀爀漀戀椀漀氀⸀ ㄀㐀㨀㄀㈀㌀㘀㠀㌀㐀⸀ 搀漀椀㨀 ㄀　⸀㌀㌀㠀㤀⼀昀洀椀挀戀⸀㈀　㈀.1236834 Keywords: tuberculosis; Mycobacterium caprae; goat; experimental infection; intranasal; endobronchial Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Sat Aug 05 16:23:16 CEST 2023 ModDate: Sat Aug 05 18:59:58 CEST 2023 ID: 0x6cad69e16d04dd94e3f45697822de3e4, 0x79c693b8c9e3084d87e5acea96919302 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: 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Melgarejo, Cobos, Planas, Fondevila, Martı́n, Cervera, Cantero, Moll, Espada, Domingo, Vidal and Pérez de Val. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Melgarejo C, Cobos A, Planas C, Fondevila J, Martı́n M, Cervera Z, Cantero G, Moll X, Espada Y, Domingo M, Vidal E and Pérez de Val B (2023) Comparison of the pathological outcome and disease progression of two Mycobacterium caprae experimental challenge models in goats: endobronchial inoculation vs. intranasal nebulization. Front. Microbiol. 14:1236834. doi: 10.3389/fmicb.2023.1236834 Cristian Melgarejo Alex Cobos Carles Planas Jaume Fondevila Maite Martı́n Zoraida Cervera Guillermo Cantero Xavier Moll Yvonne Espada Mariano Domingo Enric Vidal Bernat Pérez de Val Comparison of the pathological outcome and disease progression of two Mycobacterium caprae experimental challenge models in goats: endobronchial inoculation vs. intranasal nebulization tuberculosis Mycobacterium caprae goat experimental infection intranasal endobronchial uuid:fb97bff7-db02-4ad2-b765-f5620a086983 uuid:18199db1-04a1-49f6-8fcd-57196d906312 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 48, 789, 235, 806 Annotation: Subtype: Link Rect: 454, 800, 513, 808 Annotation: Subtype: Link Rect: 471, 791, 481, 799 Annotation: Subtype: Link Rect: 481, 791, 505, 799 Annotation: Subtype: Link Rect: 505, 791, 523, 799 Annotation: Subtype: Link Rect: 451, 782, 546, 790 Annotation: Subtype: Link Rect: 48, 728, 124, 745 Annotation: 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Subtype: Link Rect: 212, 281, 248, 293 Destination: External Annotation: Subtype: Link Rect: 252, 281, 271, 293 Destination: External Annotation: Subtype: Link Rect: 212, 269, 263, 281 Destination: External Annotation: Subtype: Link Rect: 267, 269, 286, 281 Destination: External Annotation: Subtype: Link Rect: 190, 257, 289, 269 Destination: External Annotation: Subtype: Link Rect: 48, 245, 67, 257 Destination: External Annotation: Subtype: Link Rect: 98, 137, 175, 149 Destination: External Annotation: Subtype: Link Rect: 180, 137, 199, 149 Destination: External Annotation: Subtype: Link Rect: 72, 77, 137, 89 Destination: External Annotation: Subtype: Link Rect: 139, 77, 159, 89 Destination: External Annotation: Subtype: Link Rect: 161, 77, 216, 89 Destination: External Annotation: Subtype: Link Rect: 219, 77, 238, 89 Destination: External Annotation: Subtype: Link Rect: 372, 342, 444, 354 Destination: External Annotation: Subtype: Link Rect: 448, 342, 467, 354 Destination: External Annotation: Subtype: Link Rect: 471, 342, 544, 354 Destination: External Annotation: Subtype: Link Rect: 303, 330, 322, 342 Destination: External Annotation: Subtype: Link Rect: 497, 222, 322, 222 Destination: External Annotation: Subtype: Link Rect: 324, 210, 343, 222 Destination: External Annotation: Subtype: Link Rect: 346, 210, 411, 222 Destination: External Annotation: Subtype: Link Rect: 413, 210, 432, 222 Destination: External Annotation: Subtype: Link Rect: 455, 114, 512, 126 Destination: External Annotation: Subtype: Link Rect: 514, 114, 533, 126 Destination: External Annotation: Subtype: Link Rect: 48, 33, 130, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Label: 8 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 450, 800, 546, 807 Annotation: Subtype: Link Rect: 48, 33, 130, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Label: 9 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 450, 800, 546, 807 Annotation: Subtype: Link Rect: 48, 33, 130, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Label: 10 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 450, 800, 546, 807 Annotation: Subtype: Link Rect: 233, 752, 289, 764 Destination: External Annotation: Subtype: Link Rect: 48, 740, 67, 752 Destination: External Annotation: Subtype: Link Rect: 103, 656, 161, 668 Destination: External Annotation: Subtype: Link Rect: 164, 656, 183, 668 Destination: External Annotation: Subtype: Link Rect: 239, 608, 289, 620 Destination: External Annotation: Subtype: Link Rect: 48, 596, 67, 608 Destination: External Annotation: Subtype: Link Rect: 265, 524, 67, 524 Destination: External Annotation: Subtype: Link Rect: 69, 512, 88, 524 Destination: External Annotation: Subtype: Link Rect: 130, 452, 185, 464 Destination: External Annotation: Subtype: Link Rect: 188, 452, 207, 464 Destination: External Annotation: Subtype: Link Rect: 172, 152, 213, 164 Destination: External Annotation: Subtype: Link Rect: 216, 152, 235, 164 Destination: External Annotation: Subtype: Link Rect: 210, 92, 289, 104 Destination: External Annotation: Subtype: Link Rect: 303, 752, 322, 764 Destination: External Annotation: Subtype: Link Rect: 326, 752, 386, 764 Destination: External Annotation: Subtype: Link Rect: 389, 752, 409, 764 Destination: External Annotation: Subtype: Link Rect: 476, 548, 521, 560 Destination: External Annotation: Subtype: Link Rect: 525, 548, 544, 560 Destination: External Annotation: Subtype: Link Rect: 303, 536, 322, 548 Destination: External Annotation: Subtype: Link Rect: 389, 536, 462, 548 Destination: External Annotation: Subtype: Link Rect: 466, 536, 485, 548 Destination: External Annotation: Subtype: Link Rect: 489, 536, 544, 548 Destination: External Annotation: Subtype: Link Rect: 303, 524, 322, 536 Destination: External Annotation: Subtype: Link Rect: 389, 524, 482, 536 Destination: External Annotation: Subtype: Link Rect: 487, 524, 506, 536 Destination: External Annotation: Subtype: Link Rect: 434, 500, 479, 512 Destination: External Annotation: Subtype: Link Rect: 483, 500, 502, 512 Destination: External Annotation: Subtype: Link Rect: 506, 500, 544, 512 Destination: External Annotation: Subtype: Link Rect: 303, 488, 322, 500 Destination: External Annotation: Subtype: Link Rect: 306, 416, 396, 428 Destination: External Annotation: Subtype: Link Rect: 399, 416, 418, 428 Destination: External Annotation: Subtype: Link Rect: 448, 260, 521, 272 Destination: External Annotation: Subtype: Link Rect: 525, 260, 544, 272 Destination: External Annotation: Subtype: Link Rect: 303, 248, 322, 260 Destination: External Annotation: Subtype: Link Rect: 327, 248, 346, 260 Destination: External Annotation: Subtype: Link Rect: 350, 248, 432, 260 Destination: External Annotation: Subtype: Link Rect: 436, 248, 455, 260 Destination: External Annotation: Subtype: Link Rect: 459, 248, 479, 260 Destination: External Annotation: Subtype: Link Rect: 483, 248, 544, 260 Destination: External Annotation: Subtype: Link Rect: 303, 236, 322, 248 Destination: External Annotation: Subtype: Link Rect: 327, 236, 384, 248 Destination: External Annotation: Subtype: Link Rect: 389, 236, 408, 248 Destination: External Annotation: Subtype: Link Rect: 515, 200, 353, 200 Destination: External Annotation: Subtype: Link Rect: 356, 188, 375, 200 Destination: External Annotation: Subtype: Link Rect: 48, 33, 130, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Label: 11 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 450, 800, 546, 807 Annotation: Subtype: Link Rect: 60, 297, 122, 306 Annotation: Subtype: Link Rect: 292, 262, 47, 279 Annotation: Subtype: Link Rect: 90, 225, 177, 234 Annotation: Subtype: Link Rect: 60, 189, 147, 198 Annotation: Subtype: Link Rect: 292, 153, 47, 171 Annotation: Subtype: Link Rect: 87, 118, 173, 126 Annotation: Subtype: Link Rect: 292, 73, 47, 91 Annotation: Subtype: Link Rect: 315, 305, 434, 314 Annotation: Subtype: Link Rect: 349, 269, 443, 278 Annotation: Subtype: Link Rect: 437, 241, 524, 250 Annotation: Subtype: Link Rect: 315, 207, 379, 214 Annotation: Subtype: Link Rect: 388, 185, 464, 194 Annotation: Subtype: Link Rect: 360, 158, 447, 166 Annotation: Subtype: Link Rect: 388, 130, 465, 139 Annotation: Subtype: Link Rect: 414, 95, 493, 102 Annotation: Subtype: Link Rect: 48, 32, 130, 40 Annotation: Subtype: Link Rect: 498, 32, 546, 40 Page: Label: 12 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 450, 800, 546, 807 Annotation: Subtype: Link Rect: 60, 744, 140, 751 Annotation: Subtype: Link Rect: 148, 724, 215, 731 Annotation: Subtype: Link Rect: 60, 680, 155, 687 Annotation: Subtype: Link Rect: 101, 624, 164, 631 Annotation: Subtype: Link Rect: 60, 595, 129, 603 Annotation: Subtype: Link Rect: 80, 560, 163, 567 Annotation: Subtype: Link Rect: 113, 532, 166, 539 Annotation: Subtype: Link Rect: 104, 497, 169, 504 Annotation: Subtype: Link Rect: 292, 460, 47, 477 Annotation: Subtype: Link Rect: 292, 414, 47, 433 Annotation: Subtype: Link Rect: 292, 372, 47, 389 Annotation: Subtype: Link Rect: 342, 735, 435, 743 Annotation: Subtype: Link Rect: 365, 708, 434, 715 Annotation: Subtype: Link Rect: 315, 670, 396, 679 Annotation: Subtype: Link Rect: 315, 636, 395, 643 Annotation: Subtype: Link Rect: 315, 599, 391, 607 Annotation: Subtype: Link Rect: 404, 571, 497, 580 Annotation: Subtype: Link Rect: 315, 535, 401, 543 Annotation: Subtype: Link Rect: 462, 509, 541, 516 Annotation: Subtype: Link Rect: 414, 479, 513, 488 Annotation: Subtype: Link Rect: 447, 451, 546, 460 Annotation: Subtype: Link Rect: 315, 409, 410, 416 Annotation: Subtype: Link Rect: 440, 373, 515, 380 Annotation: Subtype: Link Rect: 48, 33, 130, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Checksum: 83dccf8f Type: CRC32 Checksum: f2b6de8f8cd27f0775a221cb9112f757 Type: MD5 Checksum: b33ec60cb1ee4a3c99c43bd53a8417f21536cf2a Type: SHA-1