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Title:          Arabidopsis metacaspase MC1 localizes in stress granules, clears protein aggregates, and delays senescence
Subject:        DOI: 10.1093/plcell/koad172; The Plant Cell, 35, 9, 2023-7-1.; Abstract: Stress granules (SGs) are highly conserved cytoplasmic condensates that assemble in response to stress and contribute to maintaining protein homeostasis. These membraneless organelles are dynamic, disassembling once the stress is no longer present. Persistence of SGs due to mutations or chronic stress has been often related to age-dependent protein-misfolding diseases in animals. Here, we find that the metacaspase MC1 is dynamically recruited into SGs upon proteotoxic stress in Arabidopsis (Arabidopsis thaliana). Two predicted disordered regions, the prodomain and the 360 loop, mediate MC1 recruitment to and release from SGs. Importantly, we show that MC1 has the capacity to clear toxic protein aggregates in vivo and in vitro, acting as a disaggregase. Finally, we demonstrate that overexpressing MC1 delays senescence and this phenotype is dependent on the presence of the 360 loop and an intact catalytic domain. Together, our data indicate that MC1 regulates senescence through its recruitment into SGs and this function could potentially be linked to its remarkable protein aggregate-clearing activity.
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Author:         Nerea Ruiz-Solaní
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      Title: Arabidopsis metacaspase MC1 localizes in stress granules, clears protein aggregates, and delays senescence
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        Title: Introduction
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        Title: Results
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          Title: MC1 dynamically localizes to cytoplasmic SGs upon acute proteotoxic stress
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          Title: The IDRs of MC1 are aggregation prone and confer insolubility in vitro
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          Title: The IDRs of MC1 regulate its dynamic recruitment into SGs
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          Title: MC1 can specifically degrade aggregated proteins
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          Title: MC1 delays senescence
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        Title: Discussion
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          Title: MC1 as a SG component
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          Title: Antiaging role of MC1: physiological implications of the role of MC1 in protein aggregate clearance
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          Title: Protein purification
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          Title: Enzymatic activity assays
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          Title: Preparation of TTR aggregates
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          Title: In vitro disaggregation assay
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          Title: Heat treatments
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