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Title:           The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70
Subject:         Nature Communications, doi:10.1038/s41467-023-41150-8
Keywords:        
Author:          Lorea Velasco-Carneros
Creator:         Springer
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      Title: The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate’proteins and with Hsc70
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       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: DNAJA2 self-associates in solution
          Destination: B1
         Item: 
          Title: Several domains are involved in DNAJA2 oligomerisation
          Destination: B2
         Item: 
          Title: CryoEM structure of oligomeric DNAJA2
          Destination: B3
         Item: 
          Title: Localisation of the DNAJA2 oligomer-forming sites
          Destination: B4
         Item: 
          Title: Functionality of the DNAJA2 variants: holding activity and collaboration with Hsc70
          Destination: B5
         Item: 
          Title: Modulation of DNAJA2 oligomerisation state by substrates and Hsc70
          Destination: B6
       Item: 
        Title: Discussion
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       Item: 
        Title: Methods
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        Children: 
         Item: 
          Title: Cloning, expression and purification of proteins
          Destination: B7
         Item: 
          Title: Dynamic light scattering
          Destination: B8
         Item: 
          Title: ATPase assay
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         Item: 
          Title: Holding activity
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         Item: 
          Title: Refolding of unfolded luciferase
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         Item: 
          Title: Disaggregating activity
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         Item: 
          Title: Chaperone binding to G6PDH aggregates
          Destination: B13
         Item: 
          Title: Crosslinking and mass spectrometry (XL-MS) analysis
          Destination: B14
         Item: 
          Title: Negative staining electron microscopy
          Destination: B15
         Item: 
          Title: Nanogold labelling of Hsc70
          Destination: B16
         Item: 
          Title: Sample preparation for CryoEM
          Destination: B17
         Item: 
          Title: CryoEM data acquisition
          Destination: B18
         Item: 
          Title: Image processing and three-dimensional reconstruction
          Destination: B19
         Item: 
          Title: Homology modelling, molecular dynamics simulations and docking
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         Item: 
          Title: Statistical analysis and reproducibility
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         Item: 
          Title: Reporting summary
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       Item: 
        Title: Data availability
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       Item: 
        Title: References
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       Item: 
        Title: Acknowledgements
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       Item: 
        Title: Author contributions
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       Item: 
        Title: Competing interests
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       Item: 
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    Keywords: 
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