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Sci. 10:1213287. doi: 10.3389/fvets.2023.1213287 Keywords: fecal microbiota; canine; aging; intestinal health; nutrition Author: Anna Fernández-Pinteño Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Fri Aug 18 06:20:43 2023 CEST ModDate: Fri Aug 18 06:43:03 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.26 x 842.116 pts (A4) Page rot: 0 File size: 1189285 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HLDJBE+MuseoSans-700 Type 1C Custom yes yes yes 43 0 HCGCPT+MuseoSans-300 Type 1C Custom yes yes yes 46 0 EBAJGE+MuseoSans-300Italic Type 1C WinAnsi yes yes no 59 0 LERTDG+MinionPro-Regular Type 1C Custom yes yes no 62 0 WOHPED+MuseoSans-500 Type 1C Custom yes yes yes 69 0 OBAZBH+RMTMI Type 1C WinAnsi yes yes no 72 0 OCUAFX+MTSY Type 1C Custom yes yes yes 74 0 YINPKX+MinionPro-It Type 1C Custom yes yes no 94 0 ICZWTY+MuseoSans-500Italic Type 1C WinAnsi yes yes no 100 0 CNBJKM+MTGU Type 1C Custom yes yes no 125 0 DRNKUR+MinionPro-Bold Type 1C WinAnsi yes yes no 184 0 Times-Roman Type 1 Standard no no no 186 0 GBAUGV+RMTMIB Type 1C WinAnsi yes yes no 226 0 CNBJKM+MTGUB Type 1C Custom yes yes no 244 0 AZUWQU+MTSYB Type 1C Custom yes yes no 246 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-11-09 02:32:10 CET RepresentationInformation: pmc_10481537.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-11-03 02:24:14 CET Size: 1189285 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 373 FreeObjects: 19 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Age-associated changes in intestinal health biomarkers in dogs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: 1. Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 2. Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: 2.1. Animals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 2.2. Fecal collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 2.3. Fecal biomarkers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Children: Item: Title: 2.3.1. Microbiota analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 2.3.2. Intestinal health indicators Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 2.4. Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: 3. Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Children: Item: Title: 3.1. Quantitative real-time PCR analysis and dysbiosis index Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: 3.2. 16s rRNA sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Children: Item: Title: 3.2.1. Phylum taxonomic level Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: 3.2.2. Family taxonomic level Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: 3.2.3. Genus taxonomic level Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: 3.3. Fecal SCFAs, IgA, and cCP Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: 3.4. Correlations among qPCR, IgA, cCP, and SCFA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: 4. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Children: Item: Title: 4.1. Microbiota results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: 4.2. Beta diversity, alpha diversity, and dysbiosis index Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: 4.3. Fecal SCFAs, IgA, and cCP Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: 4.4. Main features Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: 5. Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Data availability statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Ethics statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: Conflict of interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: Publisher's note Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: Supplementary material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Info: Title: Age-associated changes in intestinal health biomarkers in dogs Subject: Fernández-Pinteño A, Pilla R, Manteca X, Suchodolski J, Torre C and Salas-Mani A (2023) Age-associated changes in intestinal 栀攀愀氀琀栀 戀椀漀洀愀爀欀攀爀猀 椀渀 搀漀最猀⸀ 䘀爀漀渀琀⸀ 嘀攀琀⸀ 匀挀椀⸀ ㄀　㨀㄀㈀㄀㌀㈀㠀㜀⸀ 搀漀椀㨀 ㄀　⸀㌀㌀㠀㤀⼀昀瘀攀琀猀⸀㈀　㈀㌀⸀㄀㈀㄀㌀㈀㠀㜩⽁畴桯爨Anna Fernández-Pinteño Keywords: fecal microbiota; canine; aging; intestinal health; nutrition Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Fri Aug 18 06:50:43 CEST 2023 ModDate: Fri Aug 18 07:13:03 CEST 2023 ID: 0xc400375b8da49d30f0f3175709246cc8, 0x254aea9aebe7fe439ed361239dbcf6cc Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 32 ImageHeight: 128 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 945 ImageHeight: 594 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: 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intestinal health; nutrition dvips + MiKTeX GPL Ghostscript 9.0 application/pdf Copyright © 2023 Fernández-Pinteño, Pilla, Manteca, Suchodolski, Torre and Salas-Mani. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Fernández-Pinteño A, Pilla R, Manteca X, Suchodolski J, Torre C and Salas-Mani A (2023) Age-associated changes in intestinal health biomarkers in dogs. Front. Vet. Sci. 10:1213287. doi: 10.3389/fvets.2023.1213287 Anna Fernández-Pinteño Rachel Pilla Xavier Manteca Jan Suchodolski Celina Torre Anna Salas-Mani Age-associated changes in intestinal health biomarkers in dogs fecal microbiota canine aging intestinal health nutrition uuid:8aa585bd-4ec0-4069-8cb4-8aea00a4e819 uuid:099c7e07-4b52-41f3-9c61-6c73634418ca Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 48, 789, 258, 806 Annotation: Subtype: Link Rect: 458, 800, 516, 808 Annotation: Subtype: Link Rect: 474, 791, 484, 799 Annotation: Subtype: Link Rect: 484, 791, 508, 799 Annotation: Subtype: Link Rect: 508, 791, 526, 799 Annotation: Subtype: Link Rect: 455, 782, 546, 790 Annotation: Subtype: Link Rect: 48, 700, 124, 717 Annotation: Subtype: Link Rect: 57, 551, 169, 559 Annotation: Subtype: Link Rect: 62, 462, 154, 470 Annotation: Subtype: Link Rect: 69, 413, 97, 420 Annotation: Subtype: Link Rect: 97, 413, 133, 420 Annotation: Subtype: Link Rect: 133, 413, 168, 420 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627, 257, 635 Annotation: Subtype: Link Rect: 92, 599, 154, 607 Annotation: Subtype: Link Rect: 354, 726, 411, 735 Annotation: Subtype: Link Rect: 420, 697, 478, 706 Annotation: Subtype: Link Rect: 405, 676, 481, 685 Annotation: Subtype: Link Rect: 351, 649, 433, 656 Annotation: Subtype: Link Rect: 424, 627, 506, 635 Annotation: Subtype: Link Rect: 344, 600, 419, 608 Annotation: Subtype: Link Rect: 48, 33, 146, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Checksum: 76fb1edb Type: CRC32 Checksum: 03cf368eb1d7565d9784725734dcf408 Type: MD5 Checksum: f71ce72be1c529e6f8b4381ecbc93565bed7fe72 Type: SHA-1