b54332ef37a6859e114afdd96325e93b pmc_10496572.pdf 6e226178cc87f319f6b53fa152219ad21816b009 pmc_10496572.pdf 14d59edd4d77a62a081f131a5cb2734001f7451aed5b4c53db47b7bd515469b4 pmc_10496572.pdf Title: OP-PUBQ230034 602..618 Creator: Arbortext Advanced Print Publisher 9.0.114/W Producer: Adobe LiveCycle PDF Generator CreationDate: Thu Aug 31 08:51:12 2023 CEST ModDate: Thu Aug 31 08:51:13 2023 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 432 x 648 pts Page rot: 0 File size: 554972 bytes Optimized: yes PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FMBPPP+AdvOT9d60b855.B Type 1C WinAnsi yes yes no 417 0 FMCAAP+AdvOTf9433e2d Type 1C Custom yes yes no 420 0 FMCABA+AdvOTb4af3d5d.I Type 1C MacRoman yes yes no 424 0 FMCAIO+AdvTT5843c571 Type 1C Custom yes yes yes 385 0 FMCAIP+AdvP80516 Type 1C Custom yes yes yes 390 0 FMCAMO+AdvP4C4E74 Type 1C Custom yes yes yes 225 0 FMCBAO+AdvP4C4E51 Type 1C Custom yes yes yes 231 0 FMCBGM+AdvP4C4E59 Type 1C Custom yes yes yes 239 0 FMCBHN+Helvetica Type 1C Custom yes yes no 236 0 FMCBLM+AdvPSMP13 Type 1C WinAnsi yes yes no 244 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-03-12 02:11:41 CET RepresentationInformation: pmc_10496572.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-03-12 02:04:21 CET Size: 554972 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 428 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Active Content List Destination: mkchap_artid Children: Item: Title: Introduction Destination: mkchap__sec Item: Title: Methods and Hypotheses Destination: mkchap__sec Item: Title: Results Destination: mkchap__sec Item: Title: Discussion Destination: mkchap__sec Item: Title: Supplementary Material Destination: mkchap__sec Item: Title: Acknowledgements Destination: mkchap_ack1_ack Item: Title: Data Availability Destination: mkchap__sec Item: Title: References Destination: mkchap_ref1_ref-list Info: Title: OP-PUBQ230034 602..618 Creator: Arbortext Advanced Print Publisher 9.0.114/W Producer: Adobe LiveCycle PDF Generator CreationDate: Thu Aug 31 09:21:12 CEST 2023 ModDate: Thu Aug 31 09:21:13 CEST 2023 ID: 0xd552dda6266395bcc45ab59504e4ba09, 0xb419c30b9af912bd6ca5d194e895f3e6 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: FMBPPP+AdvOT9d60b855.B FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: FMBPPP+AdvOT9d60b855.B Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1000, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FMCAIO+AdvTT5843c571 FontSubset: true FirstChar: 42 LastChar: 168 FontDescriptor: FontName: FMCAIO+AdvTT5843c571 Flags: Serif, Symbolic FontBBox: -156, -208, 1000, 822 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FMCAMO+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 188 FontDescriptor: FontName: FMCAMO+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FMCAAP+AdvOTf9433e2d FontSubset: true FirstChar: 30 LastChar: 223 FontDescriptor: FontName: FMCAAP+AdvOTf9433e2d Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1000, 895 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: FMCBLM+AdvPSMP13 FontSubset: true FirstChar: 68 LastChar: 68 FontDescriptor: FontName: FMCBLM+AdvPSMP13 Flags: Serif, Nonsymbolic FontBBox: 0, -302, 958, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FMCAIP+AdvP80516 FontSubset: true FirstChar: 86 LastChar: 86 FontDescriptor: FontName: FMCAIP+AdvP80516 Flags: Symbolic FontBBox: 0, -218, 989, 760 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FMCBAO+AdvP4C4E51 FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: FMCBAO+AdvP4C4E51 Flags: Symbolic FontBBox: -31, -239, 1041, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FMCABA+AdvOTb4af3d5d.I FontSubset: true FirstChar: 38 LastChar: 222 FontDescriptor: FontName: FMCABA+AdvOTb4af3d5d.I Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1000, 875 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: FMCBHN+Helvetica FontSubset: true FirstChar: 21 LastChar: 121 FontDescriptor: FontName: FMCBHN+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: FMCBGM+AdvP4C4E59 FontSubset: true FirstChar: 2 LastChar: 46 FontDescriptor: FontName: FMCBGM+AdvP4C4E59 Flags: Serif, Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: 2023-08-31T12:21:12+05:30 2023-08-31T12:21:13+05:30 Arbortext Advanced Print Publisher 9.0.114/W 2023-08-31T12:21:13+05:30 Adobe LiveCycle PDF Generator OP-PUBQ230034 602..618 application/pdf uuid:61bff727-c072-28fe-7eb2-e8ebc5fb91fc uuid:29517b97-8b6a-28c9-7b76-e8ebc5fb91fc Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 137, 527, 147, 537 Annotation: Subtype: Link Rect: 228, 527, 238, 537 Annotation: Subtype: Link Rect: 361, 527, 371, 537 Annotation: Subtype: Link Rect: 124, 514, 134, 524 Annotation: Subtype: Link Rect: 204, 514, 214, 524 Annotation: Subtype: Link Rect: 246, 85, 338, 93 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 157, 435, 304, 445 Destination: 177 Annotation: Subtype: Link Rect: 229, 397, 305, 408 Destination: 177 Annotation: Subtype: Link Rect: 131, 373, 194, 383 Destination: 164 Annotation: Subtype: Link Rect: 199, 373, 351, 383 Destination: 199 Annotation: Subtype: Link Rect: 306, 348, 365, 358 Destination: 164 Annotation: Subtype: Link Rect: 57, 336, 203, 346 Destination: 199 Annotation: Subtype: Link Rect: 89, 287, 142, 297 Destination: 177 Annotation: Subtype: Link Rect: 149, 287, 231, 297 Destination: 177 Annotation: Subtype: Link Rect: 320, 274, 367, 284 Destination: 199 Annotation: Subtype: Link Rect: 57, 262, 111, 272 Destination: 199 Annotation: Subtype: Link Rect: 190, 249, 341, 259 Destination: 177 Annotation: Subtype: Link Rect: 140, 225, 231, 235 Destination: 177 Annotation: Subtype: Link Rect: 267, 200, 367, 210 Destination: 164 Annotation: Subtype: Link Rect: 57, 188, 84, 198 Destination: 164 Annotation: Subtype: Link Rect: 342, 114, 367, 124 Destination: 177 Annotation: Subtype: Link Rect: 57, 101, 177, 111 Destination: 177 Annotation: Subtype: Link Rect: 309, 101, 367, 111 Destination: 199 Annotation: Subtype: Link Rect: 57, 89, 117, 99 Destination: 199 Annotation: Subtype: Link Rect: 214, 89, 300, 99 Destination: 164 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 157, 484, 207, 494 Destination: 199 Annotation: Subtype: Link Rect: 142, 464, 146, 474 Destination: 23 Annotation: Subtype: Link Rect: 146, 460, 146, 470 Destination: 23 Annotation: Subtype: Link Rect: 142, 400, 251, 410 Destination: 177 Annotation: Subtype: Link Rect: 242, 387, 315, 397 Destination: 177 Annotation: Subtype: Link Rect: 321, 387, 341, 397 Destination: 177 Annotation: Subtype: Link Rect: 348, 387, 368, 397 Destination: 177 Annotation: Subtype: Link Rect: 311, 194, 359, 205 Destination: 199 Annotation: Subtype: Link Rect: 204, 182, 254, 192 Destination: 199 Annotation: Subtype: Link Rect: 86, 170, 168, 180 Destination: 177 Annotation: Subtype: Link Rect: 64, 125, 67, 133 Destination: 23 Annotation: Subtype: Link Rect: 134, 105, 187, 113 Destination: 177 Annotation: Subtype: Link Rect: 159, 85, 294, 93 Destination: 177 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 101, 544, 209, 554 Destination: 199 Annotation: Subtype: Link Rect: 214, 544, 233, 554 Destination: 199 Annotation: Subtype: Link Rect: 336, 544, 367, 554 Destination: 177 Annotation: Subtype: Link Rect: 57, 532, 186, 542 Destination: 177 Annotation: Subtype: Link Rect: 61, 508, 193, 518 Destination: 177 Annotation: Subtype: Link Rect: 198, 508, 264, 518 Destination: 164 Annotation: Subtype: Link Rect: 269, 508, 350, 518 Destination: 199 Annotation: Subtype: Link Rect: 152, 471, 259, 481 Destination: 164 Annotation: Subtype: Link Rect: 175, 374, 279, 384 Destination: 177 Annotation: Subtype: Link Rect: 264, 253, 365, 263 Destination: 164 Annotation: Subtype: Link Rect: 155, 204, 262, 214 Destination: 164 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 238, 556, 314, 566 Destination: 164 Annotation: Subtype: Link Rect: 313, 544, 374, 554 Annotation: Subtype: Link Rect: 64, 531, 141, 541 Annotation: Subtype: Link Rect: 257, 350, 290, 360 Destination: 66 Annotation: Subtype: Link Rect: 210, 227, 237, 237 Destination: 76 Annotation: Subtype: Link Rect: 153, 157, 157, 167 Destination: 53 Annotation: Subtype: Link Rect: 157, 153, 157, 163 Destination: 53 Annotation: Subtype: Link Rect: 292, 129, 374, 139 Destination: 164 Annotation: Subtype: Link Rect: 64, 116, 90, 126 Destination: 164 Annotation: Subtype: Link Rect: 64, 95, 67, 103 Destination: 53 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 115, 177, 166, 187 Destination: 199 Annotation: Subtype: Link Rect: 268, 177, 302, 187 Destination: 84 Annotation: Subtype: Link Rect: 234, 77, 309, 87 Destination: 164 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 370, 183, 373, 193 Destination: 76 Annotation: Subtype: Link Rect: 373, 179, 374, 189 Destination: 76 Annotation: Subtype: Link Rect: 265, 166, 368, 176 Destination: 177 Annotation: Subtype: Link Rect: 64, 95, 67, 103 Destination: 76 Annotation: Subtype: Link Rect: 96, 95, 173, 103 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 146, 297, 216, 307 Destination: 199 Annotation: Subtype: Link Rect: 303, 277, 307, 287 Destination: 84 Annotation: Subtype: Link Rect: 307, 272, 307, 282 Destination: 84 Annotation: Subtype: Link Rect: 57, 218, 90, 228 Destination: 99 Annotation: Subtype: Link Rect: 201, 144, 232, 154 Destination: 99 Annotation: Subtype: Link Rect: 57, 85, 61, 93 Destination: 84 Annotation: Subtype: Link Rect: 346, 85, 367, 93 Annotation: Subtype: Link Rect: 57, 75, 95, 83 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 189, 106, 193, 116 Destination: 99 Annotation: Subtype: Link Rect: 193, 101, 193, 111 Destination: 99 Annotation: Subtype: Link Rect: 64, 75, 67, 83 Destination: 99 Annotation: Subtype: Link Rect: 64, 65, 140, 73 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 332, 482, 364, 492 Destination: 110 Annotation: Subtype: Link Rect: 284, 101, 315, 111 Destination: 99 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 193, 568, 225, 578 Destination: 99 Annotation: Subtype: Link Rect: 178, 544, 206, 554 Destination: 119 Annotation: Subtype: Link Rect: 207, 436, 235, 446 Destination: 126 Annotation: Subtype: Link Rect: 138, 87, 160, 95 Destination: 76 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 127, 224, 131, 234 Destination: 126 Annotation: Subtype: Link Rect: 131, 219, 131, 229 Destination: 126 Annotation: Subtype: Link Rect: 96, 152, 99, 162 Destination: 126 Annotation: Subtype: Link Rect: 99, 147, 100, 157 Destination: 126 Annotation: Subtype: Link Rect: 314, 288, 335, 296 Destination: 76 Annotation: Subtype: Link Rect: 57, 106, 61, 114 Destination: 126 Annotation: Subtype: Link Rect: 57, 65, 61, 73 Destination: 126 Annotation: Subtype: Link Rect: 262, 65, 338, 73 Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 223, 330, 326, 340 Destination: 164 Annotation: Subtype: Link Rect: 333, 330, 374, 340 Destination: 177 Annotation: Subtype: Link Rect: 64, 318, 122, 328 Destination: 177 Annotation: Subtype: Link Rect: 116, 306, 192, 316 Destination: 177 Annotation: Subtype: Link Rect: 324, 294, 374, 304 Destination: 177 Annotation: Subtype: Link Rect: 64, 282, 84, 292 Destination: 177 Annotation: Subtype: Link Rect: 90, 282, 110, 292 Destination: 177 Annotation: Subtype: Link Rect: 141, 149, 239, 159 Annotation: Subtype: Link Rect: 323, 88, 374, 98 Destination: 199 Annotation: Subtype: Link Rect: 64, 76, 125, 86 Destination: 199 Annotation: Subtype: Link Rect: 130, 76, 210, 86 Destination: 164 Annotation: Subtype: Link Rect: 216, 76, 319, 86 Destination: 199 Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 276, 381, 367, 391 Destination: 199 Annotation: Subtype: Link Rect: 57, 368, 109, 378 Destination: 199 Annotation: Subtype: Link Rect: 74, 331, 212, 341 Destination: 177 Annotation: Subtype: Link Rect: 218, 331, 362, 341 Destination: 199 Annotation: Subtype: Link Rect: 118, 206, 140, 216 Destination: 177 Annotation: Subtype: Link Rect: 144, 206, 149, 216 Destination: 177 Annotation: Subtype: Link Rect: 154, 206, 199, 216 Destination: 177 Annotation: Subtype: Link Rect: 57, 77, 155, 87 Annotation: Subtype: Link Rect: 57, 64, 202, 74 Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 195, 373, 270, 383 Annotation: Subtype: Link Rect: 352, 292, 374, 300 Annotation: Subtype: Link Rect: 72, 281, 182, 289 Annotation: Subtype: Link Rect: 196, 240, 290, 248 Annotation: Subtype: Link Rect: 162, 219, 305, 227 Annotation: Subtype: Link Rect: 72, 158, 214, 166 Annotation: Subtype: Link Rect: 245, 127, 356, 135 Annotation: Subtype: Link Rect: 183, 106, 321, 114 Annotation: Subtype: Link Rect: 339, 75, 374, 83 Annotation: Subtype: Link Rect: 72, 65, 173, 73 Page: Label: 16 Annotations: Annotation: Subtype: Link Rect: 310, 570, 367, 578 Annotation: Subtype: Link Rect: 65, 560, 120, 568 Annotation: Subtype: Link Rect: 89, 500, 233, 508 Annotation: Subtype: Link Rect: 65, 470, 204, 478 Annotation: Subtype: Link Rect: 137, 440, 248, 448 Annotation: Subtype: Link Rect: 65, 410, 166, 418 Annotation: Subtype: Link Rect: 100, 390, 227, 398 Annotation: Subtype: Link Rect: 93, 350, 232, 358 Annotation: Subtype: Link Rect: 93, 320, 209, 328 Annotation: Subtype: Link Rect: 238, 290, 358, 298 Annotation: Subtype: Link Rect: 293, 270, 367, 278 Annotation: Subtype: Link Rect: 65, 260, 129, 268 Annotation: Subtype: Link Rect: 192, 220, 325, 228 Annotation: Subtype: Link Rect: 321, 190, 367, 198 Annotation: Subtype: Link Rect: 65, 180, 157, 188 Annotation: Subtype: Link Rect: 142, 150, 291, 158 Annotation: Subtype: Link Rect: 321, 120, 367, 128 Annotation: Subtype: Link Rect: 65, 110, 147, 118 Annotation: Subtype: Link Rect: 167, 90, 304, 98 Page: Label: 17 Annotations: Annotation: Subtype: Link Rect: 72, 550, 182, 558 Annotation: Subtype: Link Rect: 260, 500, 374, 508 Annotation: Subtype: Link Rect: 72, 490, 111, 498 Annotation: Subtype: Link Rect: 270, 460, 374, 468 Annotation: Subtype: Link Rect: 72, 450, 107, 458 Annotation: Subtype: Link Rect: 285, 430, 374, 438 Annotation: Subtype: Link Rect: 72, 420, 94, 428 Annotation: Subtype: Link Rect: 147, 390, 258, 398 Annotation: Subtype: Link Rect: 190, 360, 333, 368 Annotation: Subtype: Link Rect: 162, 330, 295, 338 Annotation: Subtype: Link Rect: 170, 260, 302, 268 Annotation: Subtype: Link Rect: 295, 240, 374, 248 Annotation: Subtype: Link Rect: 72, 230, 124, 238 Annotation: Subtype: Link Rect: 339, 210, 374, 218 Annotation: Subtype: Link Rect: 72, 200, 171, 208 Annotation: Subtype: Link Rect: 162, 170, 334, 178 Annotation: Subtype: Link Rect: 341, 170, 374, 178 Annotation: Subtype: Link Rect: 72, 160, 100, 168 Annotation: Subtype: Link Rect: 106, 160, 146, 168 Annotation: Subtype: Link Rect: 209, 140, 374, 148 Annotation: Subtype: Link Rect: 72, 130, 101, 138 Annotation: Subtype: Link Rect: 317, 100, 374, 108 Annotation: Subtype: Link Rect: 72, 90, 150, 98 Checksum: ca289ec8 Type: CRC32 Checksum: b54332ef37a6859e114afdd96325e93b Type: MD5 Checksum: 6e226178cc87f319f6b53fa152219ad21816b009 Type: SHA-1 Checksum: 14d59edd4d77a62a081f131a5cb2734001f7451aed5b4c53db47b7bd515469b4 Type: SHA-256