edf0951c024a30545e5f009a04ea4995 pmc_10504824.pdf d1658ecd86733d654c4d6b7b04259fc722338adf pmc_10504824.pdf 1efc68a91ddf8e72d5610f3b87308f5ee750cf80ed0d1a225df4716d09fb62ab pmc_10504824.pdf Title: Spatial scale influences the distribution of viral diversity in the eukaryotic virome of the mosquito Culex pipiens Subject: DOI: https://doi.org/10.1093/ve/vead054, Virus Evolution, 9, 2, Published xx xxx xxx. Abstract: Our knowledge of the diversity of eukaryotic viruses has recently undergone a massive expansion. This diversity could influence host physiology through yet unknown phenomena of potential interest to the fields of health and food production. However, the assembly processes of this diversity remain elusive in the eukaryotic viromes of terrestrial animals. This situation hinders hypothesis-driven tests of virome influence on host physiology. Here, we compare taxonomic diversity between different spatial scales in the eukaryotic virome of the mosquito Culex pipiens. This mosquito is a vector of human pathogens worldwide. The experimental design involved sampling in five countries in Africa and Europe around the Mediterranean Sea and large mosquito numbers to ensure a thorough exploration of virus diversity. A group of viruses was found in all countries. This core group represented a relatively large and diverse fraction of the virome. However, certain core viruses were not shared by all host individuals in a given country, and their infection rates fluctuated between countries and years. Moreover, the distribution of coinfections in individual mosquitoes suggested random co-occurrence of those core viruses. Our results also suggested differences in viromes depending on geography, with viromes tending to cluster depending on the continent. Thus, our results unveil that the overlap in taxonomic diversity can decrease with spatial scale in the eukaryotic virome of C. pipiens. Furthermore, our results show that integrating contrasted spatial scales allows us to identify assembly patterns in the mosquito virome. Such patterns can guide future studies of virome influence on mosquito physiology. Keywords: "virome; mosquito; Culex pipiens; metagenomics."; "virome; mosquito; Culex pipiens; metagenomics." Author: Patricia Gil Creator: LuaLaTeX with hyperref package Producer: LuaLaTeX CreationDate: Wed Sep 13 17:03:57 2023 CEST ModDate: Fri Sep 15 14:46:42 2023 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 5534211 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- TDNUVE+CaeciliaLTStd-Bold CID Type 0C Identity-H yes yes yes 1990 0 XVZVYO+LMRoman10-Regular CID Type 0C Identity-H yes yes yes 1993 0 WDHNOK+CaeciliaLTStd-BoldItalic CID Type 0C Identity-H yes yes yes 1996 0 MGHHYR+CaeciliaLTStd-Roman CID Type 0C Identity-H yes yes yes 1999 0 OPIVIN+CaeciliaLTStd-Light CID Type 0C Identity-H yes yes yes 2002 0 FVXFXB+CaeciliaLTStd-Heavy CID Type 0C Identity-H yes yes yes 2005 0 LCCYSC+CaeciliaLTStd-Italic CID Type 0C 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Outlines: Item: Title: Spatial scale influences the distribution of viral diversity in the eukaryotic virome of the mosquito Culex pipiens Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Mosquito sampling Item: Title: Library preparation and sequencing Item: Title: Generation of viral operational taxonomic units Item: Title: Validation of vOTUs Item: Title: Analysis of published viromes of C. pipiens Item: Title: PCR detection of selected virus taxa Item: Title: Phylogenetic analysis Item: Title: Statistical analyses Item: Title: Results Children: Item: Title: Overlap in taxonomic diversity in the virome of C. pipiens around the Mediterranean Basin Item: Title: Presence of core taxa of the virome of C. pipiens in other regions and mosquito species Item: Title: Limited overlap in taxonomic diversity within countries Item: Title: Frequent random coinfection in individual mosquitoes Item: Title: Influence of geography on virome assembly Item: Title: Virus phylogenies do not suggest strict isolation of virus populations in the Mediterranean Basin Item: Title: Discussion Item: Title: Data availability Item: Title: Supplementary data Item: Title: Acknowledgements Item: Title: Funding Item: Title: Conflict of interest: Item: Title: References Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: OPIVIN+CaeciliaLTStd-Light Encoding: Identity-H ToUnicode: true Font: BaseFont: LCVBDB+CaeciliaLTStd-LightItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: FVXFXB+CaeciliaLTStd-Heavy Encoding: Identity-H ToUnicode: true Font: BaseFont: BYCPXM+LatinModernMath-Regular Encoding: Identity-H ToUnicode: true Font: BaseFont: TDNUVE+CaeciliaLTStd-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: BYCPXM+LatinModernMath-Regular Encoding: Identity-H ToUnicode: true Font: BaseFont: LCCYSC+CaeciliaLTStd-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: XVZVYO+LMRoman10-Regular Encoding: Identity-H ToUnicode: 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true Font: BaseFont: MGHHYR+CaeciliaLTStd-Roman CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MGHHYR+CaeciliaLTStd-Roman Flags: Symbolic FontBBox: -167, -270, 1136, 926 FontFile3: true XMP: LuaLaTeX "virome; mosquito; Culex pipiens; metagenomics."; "virome; mosquito; Culex pipiens; metagenomics." 1.5 Unknown application/pdf info:doi/https://doi.org/10.1093/ve/vead054 OUP Publishing 2023-09-13T08:03:57-07:00 en-US DOI: https://doi.org/10.1093/ve/vead054, Virus Evolution, 9, 2, Published xx xxx xxx. Abstract: Our knowledge of the diversity of eukaryotic viruses has recently undergone a massive expansion. This diversity could influence host physiology through yet unknown phenomena of potential interest to the fields of health and food production. However, the assembly processes of this diversity remain elusive in the eukaryotic viromes of terrestrial animals. This situation hinders hypothesis-driven tests of virome influence on host physiology. Here, we compare taxonomic diversity between different spatial scales in the eukaryotic virome of the mosquito Culex pipiens. This mosquito is a vector of human pathogens worldwide. The experimental design involved sampling in five countries in Africa and Europe around the Mediterranean Sea and large mosquito numbers to ensure a thorough exploration of virus diversity. A group of viruses was found in all countries. This core group represented a relatively large and diverse fraction of the virome. However, certain core viruses were not shared by all host individuals in a given country, and their infection rates fluctuated between countries and years. Moreover, the distribution of coinfections in individual mosquitoes suggested random co-occurrence of those core viruses. Our results also suggested differences in viromes depending on geography, with viromes tending to cluster depending on the continent. Thus, our results unveil that the overlap in taxonomic diversity can decrease with spatial scale in the eukaryotic virome of C. pipiens. Furthermore, our results show that integrating contrasted spatial scales allows us to identify assembly patterns in the mosquito virome. Such patterns can guide future studies of virome influence on mosquito physiology. Spatial scale influences the distribution of viral diversity in the eukaryotic virome of the mosquito Culex pipiens Patricia Gil Antoni Exbrayat Etienne Loire Ignace Rakotoarivony Florian Charriat Côme Morel Thierry Baldet Michel Boisseau Albane Marie Benoît Frances Gregory L'Ambert Mohamed Bessat Yehia Otify Maria Goffredo Giuseppe Mancini Núria Busquets Lotty Birnberg Sandra Talavera Carles Aranda Emna Ayari Selma Mejri Soufien Sghaier Amal Bennouna Hicham El Rhaffouli Thomas Balenghien Ghita Chlyeh Ouafaa Fassi Fihri Julie Reveillaud Yannick Simonin Marc Eloit Serafin Gutierrez virome; mosquito; Culex pipiens; metagenomics. virome; mosquito; Culex pipiens; metagenomics. © The Author(s) 2023. 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