f404592233ba5b340424d804e4246f28 pmc_10516499.pdf e8ca2183f4b059a88d4cd426f83458db02ed9b72 pmc_10516499.pdf 47e458bc5c7cff8cec41192e6c2c8cb9d38553f164351f5f2754ffa53d497a0c pmc_10516499.pdf Title: Severe hematotoxicity after CD19 CAR-T therapy is associated with suppressive immune dysregulation and limited CAR-T expansion Author: Kai Rejeski, Ariel Perez, Gloria Iacoboni, Viktoria Blumenberg, Veit L. Bücklein, Simon Völkl, Olaf Penack, Omar Albanyan, Sophia Stock, Fabian Müller, Philipp Karschnia, Agnese Petrera, Kayla Reid, Rawan Faramand, Marco L. Davila, Karnav Modi, Erin A. Dean, Christina Bachmeier, Michael von Bergwelt-Baildon, Frederick L Locke, Wolfgang Bethge, Lars Bullinger, Andreas Mackensen, Pere Barba, Michael D. Jain, Marion Subklewe Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64) CreationDate: Tue Sep 19 16:12:20 2023 CEST ModDate: Tue Sep 19 16:12:20 2023 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 593.972 x 756 pts Page rot: 0 File size: 3442559 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WQHSED+MyriadPro-Bold Type 1C Custom yes yes yes 211 0 QBTGSE+MyriadPro-Semibold Type 1C Custom yes yes yes 216 0 SCRKTL+SegoeUISymbol CID TrueType Identity-H yes yes yes 221 0 QYHZGT+STIXGeneral-Bold Type 1C Custom yes yes yes 226 0 BMPBXY+MyriadPro-Regular Type 1C Custom yes yes yes 231 0 KEUHPE+MinionPro-Regular Type 1C Custom yes yes yes 236 0 ZRNPVN+MinionPro-It Type 1C Custom yes yes yes 241 0 JFFDKD+STIXGeneral-Regular Type 1C Custom yes yes yes 246 0 DCUZHS+MyriadPro-It Type 1C Custom yes yes yes 251 0 MTTGBZ+MyriadPro-BoldIt Type 1C Custom yes yes yes 57 0 SCDNXO+MinionPro-Bold Type 1C Custom yes yes yes 45 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-17 17:02:08 CET RepresentationInformation: pmc_10516499.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-06 02:52:24 CET Size: 3442559 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 268 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: OneColumn PageMode: UseNone Language: en Outlines: Item: Title: INTRODUCTION Destination: sec1 Item: Title: RESULTS Destination: sec2 Children: Item: Title: Baseline patient characteristics by neutrophil recovery phenotype Destination: sec3 Item: Title: Influence of neutrophil recovery phenotypes on CAR-T related toxicity and nonrelapse mortality Destination: sec4 Item: Title: Influence of neutrophil recovery phenotypes on post CAR-T clinical outcomes Destination: sec5 Item: Title: The intermittent phenotype is characterized by decreasing inflammation over time, while the aplastic phenotype is associated with high peak IL-6 and ferritin levels Destination: sec6 Item: Title: Multivariable binary logistic analysis for the aplastic versus non-aplastic phenotype Destination: sec7 Item: Title: Increased (CAR) T cell expansion and persistence in patients with biphasic neutrophil recovery Destination: sec8 Item: Title: Unfavorable relation of CAR T cell expansion to baseline tumor load and inflammation with the aplastic phenotype Destination: sec9 Item: Title: Serum proteome analysis revealed progressive immune dysregulation and endothelial dysfunction in the aplastic patients Destination: sec10 Item: Title: DISCUSSION Destination: sec11 Item: Title: MATERIALS AND METHODS Destination: sec12 Children: Item: Title: Patients and data collection Destination: sec13 Item: Title: Defining hematological toxicity and neutrophil recovery phenotypes Destination: sec14 Item: Title: Toxicity grading Destination: sec15 Item: Title: Clinical outcomes Destination: sec16 Item: Title: Multivariable analyses for the aplastic phenotype and survival outcomes Destination: sec17 Item: Title: (CAR) T cell kinetics Destination: sec18 Item: Title: Serum proteomic analysis Destination: sec19 Item: Title: Statistical considerations Destination: sec20 Item: Title: Supplementary Materials Destination: sec21 Children: Item: Title: This PDF file includes: Destination: sec22 Item: Title: REFERENCES AND NOTES Destination: reflist Item: Title: Acknowledgments Destination: ackBk Info: Title: Severe hematotoxicity after CD19 CAR-T therapy is associated with suppressive immune dysregulation and limited CAR-T expansion Author: Kai Rejeski, Ariel Perez, Gloria Iacoboni, Viktoria Blumenberg, Veit L. Bücklein, Simon Völkl, Olaf Penack, Omar Albanyan, Sophia Stock, Fabian Müller, Philipp Karschnia, Agnese Petrera, Kayla Reid, Rawan Faramand, Marco L. Davila, Karnav Modi, Erin A. Dean, Christina Bachmeier, Michael von Bergwelt-Baildon, Frederick L Locke, Wolfgang Bethge, Lars Bullinger, Andreas Mackensen, Pere Barba, Michael D. 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Bücklein, Simon Völkl, Olaf Penack, Omar Albanyan, Sophia Stock, Fabian Müller, Philipp Karschnia, Agnese Petrera, Kayla Reid, Rawan Faramand, Marco L. Davila, Karnav Modi, Erin A. Dean, Christina Bachmeier, Michael von Bergwelt-Baildon, Frederick L Locke, Wolfgang Bethge, Lars Bullinger, Andreas Mackensen, Pere Barba, Michael D. 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