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indirect destination - referenced object 'B17' cannot be found Offset: 7288389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B30' cannot be found Offset: 7288389 MIMEtype: application/pdf PDFMetadata: Objects: 1278 FreeObjects: 3 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Genetic diversification patterns in swine influenza A virus (H1N2) in vaccinated and nonvaccinated animals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 2 Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Children: Item: Title: 2.1 Cells, viruses, and vaccine Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 2.2 Experiment design and samples collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 2.3 Evaluation of the humoral response against SIAV Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 2.4 Pathological analyses and immunohistochemistry in lung Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: 2.5 SIAV RNA detection, whole genome amplification, and sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: 2.6 Bioinformatic workflow for quasispecies genomic and evolutionary analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: 2.7 Protein structure representation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: 2.8 Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: 3 Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Children: Item: Title: 3.1 Humoral response, viral replication, and pig rectal temperature kinetics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: 3.2 Pathological findings Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: 3.3 Whole genome SIAV sequencing of inoculum, nasal swab, and BALF samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: 3.4 Inoculum SNVs and their subsequent detection in pig collected samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: 3.5 De novo SNVs identification; synonymous and nonsynonymous proportion and allocation along SIAV genome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: 3.6 De novo nonsynonymous SNV with an allele frequency greater than 5% allocation on protein domains Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: 3.7 Nucleotide diversity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: 4 Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Children: Item: Title: 4.1 Permission to reuse and copyright Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Data availability statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Ethics statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: Supplementary material Destination: 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Pérez Ayub Darji Chiara Chiapponi Llilianne Ganges Joaquim. Segalés José I. Núñez López-Valiñas Á, Valle M, Pérez M, Darji A, Chiapponi C, Ganges L, Segalés J and Núñez JI (2023) Genetic diversification patterns in swine influenza A virus (H1N2) in vaccinated and nonvaccinated animals. Front. Cell. Infect. Microbiol. 13:1258321 Copyright © 2023 López-Valiñas, Valle, Pérez, Darji, Chiapponi, Ganges, Segalés and Núñez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. swine influenza virus viral evolution vaccination NGS quasispecies Genetic diversification patterns in swine influenza A virus (H1N2) in vaccinated and nonvaccinated animals swine influenza virus, viral evolution, vaccination, NGS, quasispecies True https://www.frontiersin.org/legal/copyright-statement Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 686, 524, 707 Annotation: Subtype: Link Rect: 222, 661, 473, 682 Annotation: Subtype: Link Rect: 222, 636, 464, 657 Annotation: Subtype: Link Rect: 222, 611, 443, 632 Annotation: Subtype: Link Rect: 49, 33, 202, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 691, 125, 706 Annotation: Subtype: Link Rect: 60, 547, 144, 554 Annotation: Subtype: Link Rect: 60, 527, 127, 534 Annotation: Subtype: Link Rect: 49, 415, 155, 422 Annotation: Subtype: Link Rect: 101, 365, 160, 372 Annotation: 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