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Title:           Impact of mutagenesis and lateral gene transfer processes in bacterial susceptibility to phage in food biocontrol and phage therapy
Subject:         Introduction: The emergence of resistance and interference mechanisms to phage infection can hinder the success of bacteriophage-based applications, but the significance of these mechanisms in phage therapy has not been determined.
Keywords:        mutations, phage resistance, lateral gene transfer, phage interference, IncI1 plasmids, phage biocontrol, phage therapy
Author:          Júlia López-Pérez
CreationDate:    Mon Sep 25 08:31:27 2023 CEST
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      Title: Impact of mutagenesis and lateral gene transfer processes in bacterial susceptibility to phage in food biocontrol and phage therapy
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        Title: 1 Introduction
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       Item: 
        Title: 2 Materials and methods
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          Title: 2.1 Bacterial strains
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         Item: 
          Title: 2.2 Bacteriophage propagation and titration
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         Item: 
          Title: 2.3 Isolation of S. Typhimurium ATCC 14028 RifR variants with reduced phage susceptibility
          Destination: s2_3
         Item: 
          Title: 2.4 Spot assays
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         Item: 
          Title: 2.5 Effect of phage infection on the bacterial growth kinetics
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         Item: 
          Title: 2.6 Efficiency of plating
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         Item: 
          Title: 2.7 Phage adsorption, burst size and efficiency of centre of infection
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         Item: 
          Title: 2.8 Characterization of Salmonella LPS profiles
          Destination: s2_8
         Item: 
          Title: 2.9 Sequencing and analysis of Salmonella genomes
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         Item: 
          Title: 2.10 Construction of complemented strains
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         Item: 
          Title: 2.11 Conjugative mating assays
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         Item: 
          Title: 2.12 Introduction of kanamycin cassette on plasmids
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          Title: 2.13 Plasmid curing methods
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        Title: 3 Results
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        Children: 
         Item: 
          Title: 3.1 Isolation of S. Typhimurium ATCC14028 RifR variants with reduced UAB_Phi78-susceptibility
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         Item: 
          Title: 3.2 Molecular basis of reduced phage-susceptibility of S. Typhimurium ATCC 14028 RifR variants isolated from LAB and FOOD
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         Item: 
          Title: 3.3 Molecular basis of reduced phage-susceptibility of S. Typhimurium ATCC 14028 RifR variants isolated from PT
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       Item: 
        Title: 4 Discussion
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       Item: 
        Title: Data availability statement
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        Title: Author contributions
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       Item: 
        Title: Funding
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       Item: 
        Title: Acknowledgments
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       Item: 
        Title: Supplementary material
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       Item: 
        Title: References
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    Title: Impact of mutagenesis and lateral gene transfer processes in bacterial susceptibility to phage in food biocontrol and phage therapy
    Author: Júlia López-Pérez
    Subject: Introduction: The emergence of resistance and interference mechanisms to phage infection can hinder the success of bacteriophage-based applications, but the significance of these mechanisms in phage therapy has not been determined.
    Keywords: mutations, phage resistance, lateral gene transfer, phage interference, IncI1 plasmids, phage biocontrol, phage therapy
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  Checksum: c3a46293
   Type: CRC32
  Checksum: c8e9aade4bcba67327140bed10ebc81f
   Type: MD5
  Checksum: 99a1aed34d58bc14be270125fde913de015657f4
   Type: SHA-1
  Checksum: f2e4abbf8ca32daa2c2b78874c73ef6dd79abec6bf4dd773c1b25baef341e842
   Type: SHA-256