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Simpson Creator: Springer CreationDate: Fri Sep 1 00:23:48 2023 CEST ModDate: Wed Oct 4 10:03:41 2023 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 2927967 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-SemiCn Type 1C Custom yes no yes 371 0 MyriadPro-Semibold Type 1C Custom yes no yes 372 0 MyriadPro-SemiboldSemiCn Type 1C Custom yes no yes 384 0 MyriadPro-Bold Type 1C Custom yes no yes 388 0 ZOBOCA+STIX-Regular Type 1C Custom yes yes yes 389 0 STIX-Italic Type 1C WinAnsi yes no yes 390 0 SUTCBC+MyriadPro-SemiCn2 Type 1C WinAnsi yes yes yes 417 0 MyriadPro-SemiCn3 Type 1C Custom yes no yes 200 0 MyriadPro-BoldSemiCn Type 1C Custom yes no yes 214 0 TKIKMM+ArialMT Type 1C WinAnsi yes yes no 219 0 TKIKMM+Arial-ItalicMT Type 1C WinAnsi yes yes no 220 0 TKIKMM+Arial-BoldMT Type 1C WinAnsi yes yes no 217 0 TKIKMM+Arial-BoldItalicMT Type 1C WinAnsi yes yes no 223 0 HJOFXL+STIX-Bold Type 1C WinAnsi yes yes yes 233 0 SFTMNP+Wingdings-Regular Type 1C WinAnsi yes yes yes 328 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-07 02:38:56 CEST RepresentationInformation: pmc_10570233.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-24 02:39:14 CEST Size: 2927967 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 484 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Tralokinumab Efficacy Over 1 Year in Adults with Moderate-to-Severe Atopic Dermatitis: Pooled Data from Two Phase III Trials Children: Item: Title: Abstract Children: Item: Title: Background Item: Title: Methods Item: Title: Results Item: Title: Conclusions Item: Title: Clinical Trial Registration Item: Title: Infographic Item: Title: Plain Language Summary Item: Title: 1 Introduction Item: Title: 2 Methods Children: Item: Title: 2.1 Trial Design and Patient Population Item: Title: 2.2 Endpoints Item: Title: 2.3 Statistical Analysis Children: Item: Title: 2.3.1 Prespecified Efficacy Statistical Analysis Item: Title: 2.3.2 Post Hoc Efficacy Statistical Analysis Item: Title: 2.3.3 Post Hoc Analysis of Topical Corticosteroid (TCS) Use Item: Title: 3 Results Children: Item: Title: 3.1 Patient Disposition and Baseline Characteristics Item: Title: 3.2 Prespecified Analysis of the Primary Endpoints at Week 16 Item: Title: 3.3 Prespecified Analysis of the Maintenance Endpoints at Week 52 Item: Title: 3.4 Post Hoc Analyses of the Open-Label Arm Item: Title: 3.5 Post Hoc Analysis Following All Patients Initiated on Tralokinumab from Weeks 0 to 52 Item: Title: 3.6 TCS Use Item: Title: 4 Discussion Item: Title: 5 Conclusions Item: Title: Anchor 27 Item: Title: Acknowledgements Item: Title: References Info: Title: Tralokinumab Efficacy Over 1 Year in Adults with Moderate-to-Severe Atopic Dermatitis: Pooled Data from Two Phase III Trials Author: Eric L. 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Simpson Andrew E. Pink Andrew Blauvelt Melinda Gooderham April W. 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