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Neurol. 14:1243857. doi: 10.3389/fneur.2023.1243857 Keywords: brain tumor; neuro-oncology; prehabilitation; neuromodulation; neurorehabilitation; neurosurgery; neuroplasticity; clinical trial Author: Leonardo Boccuni Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Fri Sep 22 12:56:34 2023 CEST ModDate: Fri Sep 22 13:00:26 2023 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.26 x 842.116 pts (A4) Page rot: 0 File size: 1423452 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JHERWC+MuseoSans-700 Type 1C Custom yes yes yes 40 0 QQURTU+MuseoSans-300 Type 1C Custom yes yes yes 43 0 ZZQOAS+MuseoSans-300Italic Type 1C Custom yes yes no 56 0 PMKCSL+MinionPro-Regular Type 1C Custom yes yes no 59 0 CVWHPP+MuseoSans-500 Type 1C Custom yes yes yes 66 0 EBVOZO+MinionPro-It Type 1C Custom yes yes no 91 0 QWOSBD+MTSY Type 1C Custom yes yes yes 117 0 IAAFVL+RMTMI Type 1C WinAnsi yes yes no 201 0 CNBJKM+MTGU Type 1C Custom yes yes no 214 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-07-09 02:41:39 CEST RepresentationInformation: pmc_10577187.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-06-29 02:37:58 CEST Size: 1423452 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 381 FreeObjects: 20 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Neuromodulation-induced prehabilitation to leverage neuroplasticity before brain tumor surgery: a single-cohort feasibility trial protocol Destination: ariclecounter.1 Children: Item: Title: Introduction Destination: section*.2 Item: Title: Methods and analysis Destination: section*.3 Children: Item: Title: Study settings Destination: section*.4 Item: Title: Eligibility Destination: section*.5 Item: Title: Primary and secondary outcomes Destination: section*.6 Children: Item: Title: Brain tumor classification and surgical outcomes Destination: section*.7 Item: Title: Measurement of motor function, independency, and quality of life Destination: section*.8 Item: Title: Measurement of language/cognitive function Destination: section*.9 Item: Title: Neuroimaging Destination: section*.10 Item: Title: TMS for assessment and modulation of brain function Destination: section*.11 Item: Title: Neurophysiological assessment Destination: section*.12 Item: Title: Interventions Destination: section*.13 Children: Item: Title: Neuromodulation – Navigated rTMS Destination: section*.14 Item: Title: Neuromodulation – tDCS Destination: section*.15 Item: Title: Training of functions at risk of being compromised Destination: section*.16 Children: Item: Title: Prehabilitation motor training Destination: section*.17 Item: Title: Prehabilitation language and cognitive training Destination: section*.18 Item: Title: Discontinuation, adherence, permission for concomitant care, ancillary, and post-trial care Destination: section*.19 Item: Title: Dissemination Destination: section*.20 Item: Title: Statistical analysis Destination: section*.21 Item: Title: Ethics statement Destination: section*.22 Item: Title: Author contributions Destination: section*.23 Item: Title: Neuromodulation-induced prehabilitation in the brain tumour surgery group Destination: section*.24 Item: Title: Funding Destination: section*.25 Item: Title: Conflict of interest Destination: section*.26 Item: Title: Publisher's note Destination: section*.27 Item: Title: References Destination: section*.28 Info: Title: Neuromodulation-induced prehabilitation to leverage neuroplasticity before brain tumor surgery: a single-cohort feasibility trial protocol Author: Leonardo Boccuni Subject: Boccuni L, Abellaneda-Pérez K, Martı́n-Fernández J, Leno-Colorado D, Roca-Ventura A, Prats Bisbe A, Buloz-Osorio EA, Bartrés-Faz D, Bargalló N, Cabello-Toscano M, Pariente JC, Muñoz-Moreno E, Trompetto C, Marinelli L, Villalba-Martinez G, Duffau H, P愀猀挀甀愀氀ⴀ䰀攀漀渀攀 䄃Ā 愀渀搀 吀漀爀洀漀猀 䴀甀漀稀 䨀䴀 ㈀　㈀㌀ 一攀甀爀漀洀漀搀甀氀愀琀椀漀渀ⴀ椀渀搀甀挀攀搀 瀀爀攀栀愀戀椀氀椀琀愀琀椀漀渀 琀漀 氀攀瘀攀爀愀最攀 渀攀甀爀漀瀀氀愀猀琀椀挀椀琀礀 戀攀昀漀爀攀 戀爀愀椀渀 琀甀or surgery: a single-cohort feasibility trial protocol. Front. Neurol. 14:1243857. doi: 10.3389/fneur.2023.1243857 Keywords: brain tumor; neuro-oncology; prehabilitation; neuromodulation; neurorehabilitation; neurosurgery; neuroplasticity; clinical trial Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Fri Sep 22 13:26:34 CEST 2023 ModDate: Fri Sep 22 13:30:26 CEST 2023 ID: 0x350112c7538318b38e6e792fe24f671c, 0x2ded0acc15dce748a4e417ebdd4f9f95 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 32 ImageHeight: 128 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 2080 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1779 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: CVWHPP+MuseoSans-500 FontSubset: true FirstChar: 0 LastChar: 250 FontDescriptor: FontName: CVWHPP+MuseoSans-500 Flags: Symbolic FontBBox: 2, -210, 845, 882 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: QWOSBD+MTSY FontSubset: true FirstChar: 2 LastChar: 68 FontDescriptor: FontName: QWOSBD+MTSY Flags: Symbolic FontBBox: 0, -209, 944, 679 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: CNBJKM+MTGU FontSubset: true FirstChar: 109 LastChar: 109 FontDescriptor: FontName: CNBJKM+MTGU Flags: Symbolic FontBBox: 0, -188, 607, 450 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ZZQOAS+MuseoSans-300Italic FontSubset: true FirstChar: 39 LastChar: 243 FontDescriptor: FontName: ZZQOAS+MuseoSans-300Italic Flags: Symbolic FontBBox: -53, -200, 727, 715 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: JHERWC+MuseoSans-700 FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: JHERWC+MuseoSans-700 Flags: Symbolic FontBBox: -8, -210, 941, 722 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IAAFVL+RMTMI FontSubset: true FirstChar: 62 LastChar: 62 FontDescriptor: FontName: IAAFVL+RMTMI Flags: Nonsymbolic, AllCap FontBBox: 0, 0, 683, 455 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: QQURTU+MuseoSans-300 FontSubset: true FirstChar: 0 LastChar: 250 FontDescriptor: FontName: QQURTU+MuseoSans-300 Flags: Symbolic FontBBox: -55, -210, 890, 871 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PMKCSL+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 250 FontDescriptor: FontName: PMKCSL+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 821 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: EBVOZO+MinionPro-It FontSubset: true FirstChar: 19 LastChar: 237 FontDescriptor: FontName: EBVOZO+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 1003, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: True https://www.frontiersin.org/legal/copyright-statement 2023-09-22T16:26:34+05:30 LaTeX with hyperref package + hypdvips 2023-09-22T16:30:26+05:30 2023-09-22T16:30:26+05:30 brain tumor; neuro-oncology; prehabilitation; neuromodulation; neurorehabilitation; neurosurgery; neuroplasticity; clinical trial dvips + MiKTeX GPL Ghostscript 9.0 application/pdf Copyright © 2023 Boccuni, Abellaneda-Pérez, Martı́n-Fernández, Leno-Colorado, Roca-Ventura, Prats Bisbe, Buloz-Osorio, Bartrés-Faz, Bargalló, Cabello-Toscano, Pariente, Muñoz-Moreno, Trompetto, Marinelli, Villalba-Martinez, Duffau, Pascual-Leone and Tormos Muñoz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Boccuni L, Abellaneda-Pérez K, Martı́n-Fernández J, Leno-Colorado D, Roca-Ventura A, Prats Bisbe A, Buloz-Osorio EA, Bartrés-Faz D, Bargalló N, Cabello-Toscano M, Pariente JC, Muñoz-Moreno E, Trompetto C, Marinelli L, Villalba-Martinez G, Duffau H, Pascual-Leone Á and Tormos Muñoz JM (2023) Neuromodulation-induced prehabilitation to leverage neuroplasticity before brain tumor surgery: a single-cohort feasibility trial protocol. Front. Neurol. 14:1243857. doi: 10.3389/fneur.2023.1243857 Leonardo Boccuni Kilian Abellaneda-Pérez Jesús Martı́n-Fernández David Leno-Colorado Alba Roca-Ventura Alba Prats Bisbe Edgar Antonio Buloz-Osorio David Bartrés-Faz Nuria Bargalló Marı́a Cabello-Toscano José Carlos Pariente Emma Muñoz-Moreno Carlo Trompetto Lucio Marinelli Gloria Villalba-Martinez Hugues Duffau Álvaro Pascual-Leone Josep Marı́a Tormos Muñoz Neuromodulation-induced prehabilitation to leverage neuroplasticity before brain tumor surgery: a single-cohort feasibility trial protocol brain tumor neuro-oncology prehabilitation neuromodulation neurorehabilitation neurosurgery neuroplasticity clinical trial uuid:d781a9d9-2aed-4ac3-b67b-f7eec3e70e11 uuid:4d0c2789-db5d-40f1-b9a0-f20bfe87103c Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 48, 790, 224, 806 Annotation: Subtype: Link Rect: 456, 800, 505, 808 Annotation: Subtype: Link Rect: 473, 791, 483, 799 Annotation: Subtype: Link Rect: 483, 792, 511, 799 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