b5289fc6a7c63e106225dd5d304cb2e7  pmc_10598203.pdf
517bd36a801a9bae4552638f2fb3e97d8c19666a  pmc_10598203.pdf
be968b49db1191751ec39297e22c894c79837681cdf5a9e8dd1c9391247c6ccc  pmc_10598203.pdf

Title:           Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A
Subject:         Signal Transduction and Targeted Therapy, doi:10.1038/s41392-023-01661-8
Keywords:        
Author:          Javier Martin-Broto
Creator:         Springer
Producer:        iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Thu Oct 26 17:08:15 2023 CEST
ModDate:         Sun Nov 19 03:46:11 2023 CET
Custom Metadata: no
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           10
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       1321433 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
JNFHJK+AdvOT46dcae81+20              Type 1C           WinAnsi          yes yes no      28  0
JNFHIH+AdvOT46dcae81                 Type 1C           WinAnsi          yes yes no      29  0
JNFHJL+AdvMyriad_R                   Type 1C           WinAnsi          yes yes no      30  0
JNFHII+AdvOT65f8a23b.I               Type 1C           WinAnsi          yes yes no      31  0
JNFHIJ+AdvOT46dcae81+fb              Type 1C           Custom           yes yes yes     32  0
JNFHJM+AdvOT3b30f6db.B               Type 1C           WinAnsi          yes yes no      35  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  no     408  0
JNFGKG+AdvTT5afe5d37.B               Type 1C           WinAnsi          yes yes no     409  0
Arial-BoldMT                         Type 1C           WinAnsi          yes no  no     410  0
JNFHAG+AdvOTa20b42a7                 Type 1C           WinAnsi          yes yes no     411  0
JNFHAH+AdvOT5cf73554.I               Type 1C           WinAnsi          yes yes no     412  0
JNFHAI+AdvTT6780a46b                 Type 1C           WinAnsi          yes yes no      36  0
JNFHAJ+AdvTT2876772e+27              Type 1C           Custom           yes yes yes    413  0
JNFMPN+AdvOT919a0533.B               Type 1C           WinAnsi          yes yes no      33  0
JNFOBH+AdvOT7d2ebc01                 Type 1C           WinAnsi          yes yes no      34  0
JNFOEH+AdvTTab7e17fd                 Type 1C           WinAnsi          yes yes no      60  0
JNFOFI+AdvTT6780a46b+20              Type 1C           WinAnsi          yes yes no      61  0
JNGPNP+AdvOT46dcae81+03              Type 1C           Custom           yes yes yes    132  0
JNGPMN+AdvOT46dcae81+22              Type 1C           Custom           yes yes yes    133  0
JNGPNO+AdvTT7b515deb                 Type 1C           WinAnsi          yes yes no     134  0
JNHABO+AdvTT6780a46b+fb              Type 1C           Custom           yes yes yes    147  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-05-07 02:38:55 CEST
 RepresentationInformation: pmc_10598203.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-04-24 02:39:12 CEST
  Size: 1321433
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 500
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A
      Destination: title_link
      Children: 
       Item: 
        Title: Introduction
        Destination: A1
       Item: 
        Title: Results
        Destination: A2
       Item: 
        Title: Discussion
        Destination: A3
       Item: 
        Title: Material and methods
        Destination: A4
        Children: 
         Item: 
          Title: Study design and participants
          Destination: B1
         Item: 
          Title: CDK4 and CDKN2A cut-off reference for RNA overexpression
          Destination: B2
         Item: 
          Title: Patient screening
          Destination: B3
         Item: 
          Title: Immunohistochemistry
          Destination: B4
         Item: 
          Title: Copy number variation (CNV) and single nucleotide variant (SNV) analysis
          Destination: B5
         Item: 
          Title: Clinical procedures
          Destination: B6
         Item: 
          Title: Statistical analysis
          Destination: B7
       Item: 
        Title: Acknowledgements
        Destination: A5
       Item: 
        Title: Author contributions
        Destination: A6
       Item: 
        Title: ADDITIONAL INFORMATION
        Destination: M1
       Item: 
        Title: References
        Destination: A7
   Info: 
    Title: Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A
    Author: Javier Martin-Broto
    Subject: Signal Transduction and Targeted Therapy, doi:10.1038/s41392-023-01661-8
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Thu Oct 26 17:38:15 CEST 2023
    ModDate: Sun Nov 19 03:46:11 CET 2023
   ID: 0xcdec956c8ba900f15670e826d9882437, 0x89c6f59e75f381c72d7c70b0f4a4ecf0
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 96
      ImageHeight: 82
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1500
      ImageHeight: 1005
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1350
      ImageHeight: 1645
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1975
      ImageHeight: 1070
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: JNFHIJ+AdvOT46dcae81+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: JNFHIJ+AdvOT46dcae81+fb
       Flags: Symbolic
       FontBBox: 0, 0, 739, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JNFMPN+AdvOT919a0533.B
      FontSubset: true
      FirstChar: 46
      LastChar: 108
      FontDescriptor: 
       FontName: JNFMPN+AdvOT919a0533.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 656, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JNFOBH+AdvOT7d2ebc01
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: JNFOBH+AdvOT7d2ebc01
       Flags: Nonsymbolic
       FontBBox: -31, -208, 958, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JNFHJM+AdvOT3b30f6db.B
      FontSubset: true
      FirstChar: 46
      LastChar: 121
      FontDescriptor: 
       FontName: JNFHJM+AdvOT3b30f6db.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JNFHAI+AdvTT6780a46b
      FontSubset: true
      FirstChar: 37
      LastChar: 122
      FontDescriptor: 
       FontName: JNFHAI+AdvTT6780a46b
       Flags: Nonsymbolic
       FontBBox: -41, -250, 875, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JNGPNP+AdvOT46dcae81+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: JNGPNP+AdvOT46dcae81+03
       Flags: Symbolic
       FontBBox: -31, -208, 739, 802
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JNGPMN+AdvOT46dcae81+22
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: JNGPMN+AdvOT46dcae81+22
       Flags: Symbolic
       FontBBox: 0, -145, 687, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JNGPNO+AdvTT7b515deb
      FontSubset: true
      FirstChar: 174
      LastChar: 174
      FontDescriptor: 
       FontName: JNGPNO+AdvTT7b515deb
       Flags: Nonsymbolic
       FontBBox: -93, -187, 854, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JNHABO+AdvTT6780a46b+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: JNHABO+AdvTT6780a46b+fb
       Flags: Symbolic
       FontBBox: 9, 0, 875, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JNFGKG+AdvTT5afe5d37.B
      FontSubset: true
      FirstChar: 65
      LastChar: 84
      FontDescriptor: 
       FontName: JNFGKG+AdvTT5afe5d37.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 895, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Arial-BoldMT
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JNFHAG+AdvOTa20b42a7
      FontSubset: true
      FirstChar: 47
      LastChar: 120
      FontDescriptor: 
       FontName: JNFHAG+AdvOTa20b42a7
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -239, 979, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JNFHJK+AdvOT46dcae81+20
      FontSubset: true
      FirstChar: 146
      LastChar: 151
      FontDescriptor: 
       FontName: JNFHJK+AdvOT46dcae81+20
       Flags: Nonsymbolic
       FontBBox: 0, -197, 1125, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JNFHAH+AdvOT5cf73554.I
      FontSubset: true
      FirstChar: 47
      LastChar: 78
      FontDescriptor: 
       FontName: JNFHAH+AdvOT5cf73554.I
       Flags: Nonsymbolic
       FontBBox: -145, -239, 1093, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JNFOEH+AdvTTab7e17fd
      FontSubset: true
      FirstChar: 43
      LastChar: 61
      FontDescriptor: 
       FontName: JNFOEH+AdvTTab7e17fd
       Flags: Nonsymbolic
       FontBBox: -156, -250, 1072, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JNFHAJ+AdvTT2876772e+27
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: JNFHAJ+AdvTT2876772e+27
       Flags: Symbolic
       FontBBox: 0, -197, 968, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JNFHIH+AdvOT46dcae81
      FontSubset: true
      FirstChar: 35
      LastChar: 246
      FontDescriptor: 
       FontName: JNFHIH+AdvOT46dcae81
       Flags: Nonsymbolic
       FontBBox: -41, -250, 833, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JNFOFI+AdvTT6780a46b+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: JNFOFI+AdvTT6780a46b+20
       Flags: Nonsymbolic
       FontBBox: 0, -114, 1156, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JNFHJL+AdvMyriad_R
      FontSubset: true
      FirstChar: 35
      LastChar: 121
      FontDescriptor: 
       FontName: JNFHJL+AdvMyriad_R
       Flags: Nonsymbolic
       FontBBox: -41, -239, 1125, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JNFHII+AdvOT65f8a23b.I
      FontSubset: true
      FirstChar: 44
      LastChar: 122
      FontDescriptor: 
       FontName: JNFHII+AdvOT65f8a23b.I
       Flags: Nonsymbolic
       FontBBox: -104, -250, 885, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41392-023-01661-8</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Javier Martin-Broto</rdf:li>
               <rdf:li>Jeronimo Martinez-Garcia</rdf:li>
               <rdf:li>David S. Moura</rdf:li>
               <rdf:li>Andres Redondo</rdf:li>
               <rdf:li>Antonio Gutierrez</rdf:li>
               <rdf:li>Antonio Lopez-Pousa</rdf:li>
               <rdf:li>Javier Martinez-Trufero</rdf:li>
               <rdf:li>Isabel Sevilla</rdf:li>
               <rdf:li>Roberto Diaz-Beveridge</rdf:li>
               <rdf:li>Maria Pilar Solis-Hernandez</rdf:li>
               <rdf:li>Amancio Carnero</rdf:li>
               <rdf:li>Marco Perez</rdf:li>
               <rdf:li>David Marcilla</rdf:li>
               <rdf:li>Jesus Garcia-Foncillas</rdf:li>
               <rdf:li>Pablo Romero</rdf:li>
               <rdf:li>Javier Fernandez-Jara</rdf:li>
               <rdf:li>Daniel Lopez-Lopez</rdf:li>
               <rdf:li>Ivan Arribas</rdf:li>
               <rdf:li>Nadia Hindi</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag></rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Signal Transduction and Targeted Therapy, doi:10.1038/s41392-023-01661-8</rdf:li>
            </rdf:Alt>
         </dc:description>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2023-11-19T03:46:11+01:00</xmp:ModifyDate>
         <xmp:CreateDate>2023-10-26T20:38:15+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2023-11-19T03:46:11+01:00</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords></pdf:Keywords>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer></rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:c8d057d3-87ef-4c0b-9e18-3f053f43dd88</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:08258892-aa2d-4003-b783-0aad05faef2c</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:de24ff2b-feb7-45f4-b760-1b1ca9ca8a58</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2023-10-26T20:39:01+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 524, 704, 526, 736
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 524, 709, 544, 740
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 544, 695, 549, 705
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 544, 695, 549, 705
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 124, 617, 125, 626
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 124, 617, 125, 626
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 134, 617, 135, 626
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 125, 617, 134, 626
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 133, 617, 134, 626
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 488, 617, 489, 626
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 488, 617, 489, 626
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 498, 617, 499, 626
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 489, 617, 498, 626
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 497, 617, 498, 626
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 501, 606, 502, 615
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 501, 606, 502, 615
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 510, 606, 511, 615
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 502, 606, 510, 615
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 509, 606, 510, 615
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 155, 595, 156, 604
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 155, 595, 156, 604
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 165, 595, 166, 604
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 156, 595, 165, 604
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 164, 595, 165, 604
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 303, 72, 312
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 73, 303, 77, 312
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 175, 303, 179, 312
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 180, 303, 183, 312
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 223, 303, 226, 312
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 120, 293, 124, 302
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 280, 293, 283, 302
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 182, 224, 185, 233
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 186, 224, 190, 233
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 89, 204, 96, 213
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 100, 204, 106, 213
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 484, 333, 491, 342
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 405, 264, 412, 272
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 342, 244, 348, 253
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 350, 244, 357, 253
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 510, 234, 517, 243
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 147, 80, 205, 87
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 458, 749, 549, 757
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 260, 399, 267, 408
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 286, 369, 293, 378
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 193, 299, 200, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 99, 146, 104, 155
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 204, 56, 209, 65
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 380, 315, 385, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 443, 216, 448, 225
       Flags: Print
       AppearanceDictionary: true
       Destination: 66
      Annotation: 
       Subtype: Link
       Rect: 364, 196, 368, 205
       Flags: Print
       AppearanceDictionary: true
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 437, 146, 442, 155
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 239, 205, 244, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 258, 145, 263, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 490, 683, 494, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 347, 478, 354, 487
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 519, 438, 525, 447
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 529, 438, 536, 447
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 415, 358, 422, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 286, 265, 293, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 200, 235, 207, 244
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 254, 186, 260, 195
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 258, 126, 265, 135
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 266, 126, 273, 135
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 412, 285, 418, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 552, 245, 559, 254
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 463, 225, 470, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 552, 166, 559, 175
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 502, 126, 509, 135
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 529, 106, 536, 115
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 519, 76, 526, 85
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 48, 443, 55, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 95, 393, 102, 402
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 133, 363, 140, 372
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 221, 344, 228, 352
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 230, 344, 237, 352
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 406, 274, 412, 283
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 413, 254, 420, 263
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 318, 224, 325, 233
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 493, 214, 500, 223
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 377, 164, 384, 173
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
     Thumb: true
    Page: 
     Label: 6
     Thumb: true
    Page: 
     Label: 7
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 79, 103, 86, 112
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 87, 103, 94, 112
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 265, 83, 272, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 124, 63, 131, 72
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 541, 192, 548, 201
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 71, 140, 199, 147
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 541, 302, 559, 309
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 311, 293, 422, 300
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: a5b51d6e
   Type: CRC32
  Checksum: b5289fc6a7c63e106225dd5d304cb2e7
   Type: MD5
  Checksum: 517bd36a801a9bae4552638f2fb3e97d8c19666a
   Type: SHA-1
  Checksum: be968b49db1191751ec39297e22c894c79837681cdf5a9e8dd1c9391247c6ccc
   Type: SHA-256