5e88d136e5f9aa454d9e6de9d6015dd6 pmc_10611265.pdf 720025d509eff3df86cc1031b53adcc0e87b5eb1 pmc_10611265.pdf 485fe2c22aaa5905699cbbf1ff29ccae87cbb8b616eaa98726d5cf60a7f39056 pmc_10611265.pdf Title: Feline Morbillivirus: Clinical Relevance of a Widespread Endemic Viral Infection of Cats Subject: Feline morbillivirus (FeMV) was first isolated in 2012 from stray cats in Hong Kong. It has been found in association with tubulointerstitial nephritis (TIN), the most common cause of feline chronic kidney disease (CKD). However, viral host spectrum and virus tropism go beyond the domestic cat and kidney tissues. The viral genetic diversity of FeMV is extensive, but it is not known if this is clinically relevant. Urine and kidney tissues have been widely tested in attempts to confirm associations between FeMV infection and renal disease, but samples from both healthy and sick cats can test positive and some cross-sectional studies have not found associations between FeMV infection and CKD. There is also evidence for acute kidney injury following infection with FeMV. The results of prevalence studies differ greatly depending on the population tested and methodologies used for detection, but worldwide distribution of FeMV has been shown. Experimental studies have confirmed previous field observations that higher viral loads are present in the urine compared to other tissues, and renal TIN lesions associated with FeMV antigen have been demonstrated, alongside virus lymphotropism and viraemia-associated lymphopenia. Longitudinal field studies have revealed persistent viral shedding in urine, although infection can be cleared spontaneously.20pt Keywords: FeMV; cat; urine; CKD; TIN; host spectrum; epidemiology; experimental infection; pathology; diagnosis Author: Maria Grazia Pennisi, Sándor Belák, Séverine Tasker, Diane D. Addie, Corine Boucraut-Baralon, Herman Egberink, Tadeusz Frymus, Katrin Hartmann, Regina Hofmann-Lehmann, Albert Lloret, Fulvio Marsilio, Etienne Thiry, Uwe Truyen, Karin Möstl and Margaret J. Hosie Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Oct 13 11:40:55 2023 CEST ModDate: Fri Oct 13 11:44:46 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 778688 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GIFXFT+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 SXQPWE+VnURWPalladioL Type 1 Custom yes yes no 15 0 ARTGCU+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 KGFQOM+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 XCUGMS+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 HOWKDX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 VORBJF+CMSY10 Type 1 Builtin yes yes no 68 0 OVNEXW+EURM10 Type 1 Builtin yes yes no 90 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 108 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 112 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 116 0 BCDIEE+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 120 0 BCDJEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 127 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-01-17 02:28:11 CET RepresentationInformation: pmc_10611265.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-01-12 02:23:09 CET Size: 778688 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 567 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Virus Properties and Host Spectrum Destination: section.2 Item: Title: Epidemiology Destination: section.3 Item: Title: Acute FeMV Infection as Defined in Cats by Experimental Models and Sparse Field Data Destination: section.4 Item: Title: Persistent Infection Documented in Natural Feline Infection Studies Destination: section.5 Item: Title: Difficulties in Obtaining Field Study Evidence of FeMV Pathogenicity Destination: section.6 Item: Title: Conclusions and Future Directions Destination: section.7 Item: Title: References Destination: section.8 Info: Title: Feline Morbillivirus: Clinical Relevance of a Widespread Endemic Viral Infection of Cats Author: Maria Grazia Pennisi, Sándor Belák, Séverine Tasker, Diane D. Addie, Corine Boucraut-Baralon, Herman Egberink, Tadeusz Frymus, Katrin Hartmann, Regina Hofmann-Lehmann, Albert Lloret, Fulvio Marsilio, Etienne Thiry, Uwe Truyen, Karin Möstl and Margaret J. Hosie Subject: Feline morbillivirus (FeMV) was first isolated in 2012 from stray cats in Hong Kong. It has been found in association with tubulointerstitial nephritis (TIN), the most common cause of feline chronic kidney disease (CKD). However, viral host spectrum and virus tropism go beyond the domestic cat and kidney tissues. The viral genetic diversity of FeMV is extensive, but it is not known if this is clinically relevant. Urine and kidney tissues have been widely tested in attempts to confirm associations between FeMV infection and renal disease, but samples from both healthy and sick cats can test positive and some cross-sectional studies have not found associations between FeMV infection and CKD. There is also evidence for acute kidney injury following infection with FeMV. The results of prevalence studies differ greatly depending on the population tested and methodologies used for detection, but worldwide distribution of FeMV has been shown. Experimental studies have confirmed previous field observations that higher viral loads are present in the urine compared to other tissues, and renal TIN lesions associated with FeMV antigen have been demonstrated, alongside virus lymphotropism and viraemia-associated lymphopenia. Longitudinal field studies have revealed persistent viral shedding in urine, although infection can be cleared spontaneously.20pt Keywords: FeMV; cat; urine; CKD; TIN; host spectrum; epidemiology; experimental infection; pathology; diagnosis Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Oct 13 11:40:55 CEST 2023 ModDate: Fri Oct 13 11:44:46 CEST 2023 ID: 0x683997fa7e5320a84630c6a603011ff6, 0x683997fa7e5320a84630c6a603011ff6 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: ARTGCU+URWPalladioL-Bold FontSubset: true FirstChar: 2 LastChar: 246 FontDescriptor: FontName: ARTGCU+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VORBJF+CMSY10 FontSubset: true FirstChar: 0 LastChar: 14 FontDescriptor: FontName: VORBJF+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: KGFQOM+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 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