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Title:           The prognostic impact of SIGLEC5-induced impairment of CD8+ T cell activation in sepsis
Subject:         eBioMedicine, 97 (2023) 104841. doi:10.1016/j.ebiom.2023.104841
Author:          Roberto Lozano-Rodríguez
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     Item: 
      Title: The prognostic impact of SIGLEC5-induced impairment of CD8+ T cell activation in sepsis
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       Item: 
        Title: Introduction
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       Item: 
        Title: Methods
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        Children: 
         Item: 
          Title: Study design
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         Item: 
          Title: Healthy volunteers and patients’ samples
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         Item: 
          Title: Mouse strains
          Destination: slink3
         Item: 
          Title: Cell culture conditions
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         Item: 
          Title: ELISA protocol
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         Item: 
          Title: Antibodies and flow cytometry analysis
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         Item: 
          Title: In vitro LPS stimulation
          Destination: slink7
         Item: 
          Title: In silico analysis of genomic and protein sequences
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         Item: 
          Title: Monocyte nucleofection procedure
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         Item: 
          Title: Chromatin immunoprecipitation (ChIP) assay
          Destination: slink10
         Item: 
          Title: RNA isolation and RT-qPCR
          Destination: slink11
         Item: 
          Title: Lymphocyte proliferation assays
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         Item: 
          Title: Apoptosis assay
          Destination: slink13
         Item: 
          Title: Binding assay protocol
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         Item: 
          Title: Mouse endotoxin in vivo model
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         Item: 
          Title: Mouse cecal ligation and puncture (CLP) in vivo model
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         Item: 
          Title: Histological analysis
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         Item: 
          Title: Statistical analysis
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         Item: 
          Title: Ethics
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         Item: 
          Title: Role of the funding source
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       Item: 
        Title: Results
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         Item: 
          Title: LPS induces SIGLEC5 expression in human monocytes in a HIF1α-dependent manner
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         Item: 
          Title: SIGLEC5 displays IC ligand hallmarks
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         Item: 
          Title: Soluble SIGLEC5 specifically impairs CD8+, but not CD4+ T cell proliferation
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         Item: 
          Title: SIGLEC5 reduces survival in mouse models of sepsis
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         Item: 
          Title: Monocyte from septic patients modulate CD8+ T cell proliferation thought SIGLEC5
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         Item: 
          Title: SIGLEC5 is a biomarker of prognosis in septic patients
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        Title: Discussion
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        Title: ContributorsLópez-Collazo, E. performed the conceptualisation of the study. Lozano-Rodríguez, R. and Avendaño-Ortíz, J. per ...
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        Title: Data sharing statementThe data that support the findings of this study are available from the corresponding author upon rea ...
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        Title: Declaration of interests
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        Title: Acknowledgements
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       Item: 
        Title: Appendix A. Supplementary data
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       Item: 
        Title: References
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  Checksum: cdb328ed
   Type: CRC32
  Checksum: ebb1a3430107b4d4e292a2d60d01e219
   Type: MD5
  Checksum: b1fb1ce31ee8b4f56eed8732b909a09094e2a2bd
   Type: SHA-1
  Checksum: 8e1620c3d2eabd71fcf8c3962ce0803e36f78fb6c9b44e7ca7f56529fcc208ff
   Type: SHA-256