ca6397bbabc342c3ffe90459a056a8a3 pmc_10646843.pdf 37fc3a3cc59ba161e1bc952bdd3c228c6e6e5e98 pmc_10646843.pdf f9f15f10c062c887e3401a2a17d2d575959698589d88243812806c50c03e3e99 pmc_10646843.pdf Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Fri Nov 3 19:07:46 2023 CET ModDate: Fri Nov 3 19:07:50 2023 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 3471643 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SEPFXO+ArialMT CID TrueType Identity-H yes yes yes 388 0 JEHIQG+FrutigerLTPro-LightCn Type 1C Custom yes yes yes 367 0 LSDKSC+FrutigerLTPro-BoldCn Type 1C Custom yes yes yes 368 0 VAGHNI+FrutigerLTPro-Condensed Type 1C Custom yes yes yes 369 0 UWWBZK+FrutigerLTPro-CondensedIta Type 1C WinAnsi yes yes yes 370 0 YGOKSC+FrutigerLTPro-LightCnIta Type 1C Custom yes yes yes 389 0 YDNKDC+ClassicalGaramondBT-Roman TrueType WinAnsi yes yes yes 395 0 JEHIQG+FrutigerLTPro-LightCn Type 1C WinAnsi yes yes yes 448 0 YGOKSC+FrutigerLTPro-LightCnIta Type 1C Custom yes yes yes 450 0 LSDKSC+FrutigerLTPro-BoldCn Type 1C WinAnsi yes yes yes 452 0 LRDPDC+ClassicalGaramondBT-Roman CID TrueType Identity-H yes yes yes 266 0 MBKLRA+Symbol Type 1C Custom yes yes yes 270 0 BAXCTW+ClassicalGaramondBT-Italic TrueType WinAnsi yes yes yes 259 0 JEHIQG+FrutigerLTPro-LightCn Type 1C WinAnsi yes yes yes 262 0 YGOKSC+FrutigerLTPro-LightCnIta Type 1C Custom yes yes yes 260 0 LSDKSC+FrutigerLTPro-BoldCn Type 1C WinAnsi yes yes yes 265 0 IVHNNI+FrutigerLTPro-BoldCnIta Type 1C WinAnsi yes yes yes 285 0 JEHIQG+FrutigerLTPro-LightCn Type 1C WinAnsi yes yes yes 288 0 YGOKSC+FrutigerLTPro-LightCnIta Type 1C Custom yes yes yes 291 0 LSDKSC+FrutigerLTPro-BoldCn Type 1C WinAnsi yes yes yes 290 0 EXHPJQ+FrutigerLTStd-Cn Type 1C WinAnsi yes yes yes 295 0 DYXJVS+FrutigerLTStd-BoldCn Type 1C WinAnsi yes yes yes 296 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-04-04 02:49:47 CEST RepresentationInformation: pmc_10646843.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-03-15 02:37:12 CET Size: 3471643 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 475 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Spanish cohort of VEXAS syndrome: clinical manifestations, outcome of treatments and novel evidences about UBA1 mosaicism Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Methods Children: Item: Title: Patients Item: Title: Molecular genetics Item: Title: Cell isolation Item: Title: Cytokines profile Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: Identification of patients with UBA1 variants Item: Title: Clinical features and analytical abnormalities in patients with VEXAS syndrome Item: Title: UBA1 mosaicism analyses Item: Title: Outcome of medical treatments Item: Title: Phenotype and genotype rescue by allogeneic haematopoietic stem cell transplantation Item: Title: Circulating cytokines Item: Title: Discussion Item: Title: References Info: Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Fri Nov 03 19:37:46 CET 2023 ModDate: Fri Nov 03 19:37:50 CET 2023 ID: 0x3c39bc1dfce89f4194e2d4a59788b01b, 0x204a25663926f74484a4866dc1ca65ef Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1228 ImageHeight: 663 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2409 ImageHeight: 3429 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2431 ImageHeight: 3309 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2446 ImageHeight: 3327 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: SEPFXO+ArialMT Encoding: Identity-H ToUnicode: true Font: BaseFont: LRDPDC+ClassicalGaramondBT-Roman Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: LSDKSC+FrutigerLTPro-BoldCn FontSubset: true FirstChar: 31 LastChar: 151 FontDescriptor: FontName: LSDKSC+FrutigerLTPro-BoldCn Flags: Nonsymbolic FontBBox: -112, -250, 1000, 940 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VAGHNI+FrutigerLTPro-Condensed FontSubset: true FirstChar: 29 LastChar: 215 FontDescriptor: FontName: VAGHNI+FrutigerLTPro-Condensed Flags: Nonsymbolic FontBBox: -105, -250, 1000, 929 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: UWWBZK+FrutigerLTPro-CondensedIta FontSubset: true FirstChar: 49 LastChar: 85 FontDescriptor: FontName: UWWBZK+FrutigerLTPro-CondensedIta Flags: Nonsymbolic, Italic FontBBox: -166, -250, 992, 929 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: YGOKSC+FrutigerLTPro-LightCnIta FontSubset: true FirstChar: 31 LastChar: 121 FontDescriptor: FontName: YGOKSC+FrutigerLTPro-LightCnIta Flags: Nonsymbolic FontBBox: -161, -250, 991, 919 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: EXHPJQ+FrutigerLTStd-Cn FontSubset: true FirstChar: 67 LastChar: 117 FontDescriptor: FontName: EXHPJQ+FrutigerLTStd-Cn Flags: Nonsymbolic FontBBox: -105, -250, 1000, 929 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: DYXJVS+FrutigerLTStd-BoldCn FontSubset: true FirstChar: 67 LastChar: 83 FontDescriptor: FontName: DYXJVS+FrutigerLTStd-BoldCn Flags: Nonsymbolic FontBBox: -112, -250, 1000, 940 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: IVHNNI+FrutigerLTPro-BoldCnIta FontSubset: true FirstChar: 49 LastChar: 85 FontDescriptor: FontName: IVHNNI+FrutigerLTPro-BoldCnIta Flags: Nonsymbolic FontBBox: -173, -250, 1012, 940 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MBKLRA+Symbol FontSubset: true FirstChar: 27 LastChar: 31 FontDescriptor: FontName: MBKLRA+Symbol Flags: Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: JEHIQG+FrutigerLTPro-LightCn FontSubset: true FirstChar: 29 LastChar: 252 FontDescriptor: FontName: JEHIQG+FrutigerLTPro-LightCn Flags: Nonsymbolic FontBBox: -100, -250, 1000, 919 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: BAXCTW+ClassicalGaramondBT-Italic FontSubset: true FirstChar: 49 LastChar: 85 FontDescriptor: FontName: BAXCTW+ClassicalGaramondBT-Italic Flags: Serif, Nonsymbolic FontBBox: -167, -237, 1275, 963 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: YDNKDC+ClassicalGaramondBT-Roman FontSubset: true FirstChar: 32 LastChar: 237 FontDescriptor: FontName: YDNKDC+ClassicalGaramondBT-Roman Flags: Serif, Nonsymbolic FontBBox: -166, -237, 1261, 963 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: LRDPDC+ClassicalGaramondBT-Roman CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: LRDPDC+ClassicalGaramondBT-Roman Flags: Serif, Symbolic FontBBox: -166, -237, 1261, 963 FontFile2: true Font: BaseFont: SEPFXO+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: SEPFXO+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1006 FontFile2: true XMP: doi:ard-2023-224460 application/pdf 2023-11-03T23:37:46+05:30 2023-11-03T23:37:50+05:30 2023-11-03T23:37:50+05:30 Adobe InDesign 15.1 (Windows) uuid:38c52524-ffe1-41af-ba99-59187cd63333 xmp.did:B2C59A163194E611BD009A7CB80B8EC7 xmp.id:373e3884-1ba1-d64c-8b00-c7484e030e0d proof:pdf xmp.iid:01677450-a115-ee4e-9237-84f7fe1113bf xmp.did:2f6b03ec-14e7-154b-93fb-74871588fcea xmp.did:B2C59A163194E611BD009A7CB80B8EC7 default converted from application/x-indesign to application/pdf Adobe InDesign 15.1 (Windows) / 2023-11-03T23:37:46+05:30 a8db36e1-7174-40e0-9a41-76999827bd95 Adobe PDF Library 15.0 False Pages: Page: Label: 1594 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 67, 38, 113, 20 Annotation: Subtype: Link Rect: 529, 34, 555, 18 Annotation: Subtype: Link Rect: 372, 642, 381, 626 Annotation: Subtype: Link Rect: 228, 626, 237, 611 Annotation: Subtype: Link Rect: 399, 626, 408, 611 Annotation: Subtype: Link Rect: 341, 610, 350, 595 Annotation: Subtype: Link Rect: 471, 610, 480, 595 Annotation: Subtype: Link Rect: 227, 565, 236, 550 Annotation: Subtype: Link Rect: 339, 565, 348, 550 Annotation: Subtype: Link Rect: 373, 534, 382, 519 Annotation: Subtype: Link Rect: 364, 519, 373, 503 Annotation: Subtype: Link Rect: 491, 443, 500, 428 Annotation: Subtype: Link Rect: 390, 427, 399, 412 Annotation: Subtype: Link Rect: 97, 357, 123, 348 Annotation: Subtype: Link Rect: 42, 348, 120, 339 Annotation: Subtype: Link Rect: 42, 339, 65, 330 Annotation: Subtype: Link Rect: 40, 171, 136, 148 Annotation: Subtype: Link Rect: 422, 219, 426, 208 ActionDest: 174 Annotation: Subtype: Link Rect: 388, 87, 397, 76 ActionDest: 174 Annotation: Subtype: Link Rect: 412, 54, 415, 43 ActionDest: 174 Page: Label: 1595 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 223, 120, 236, 109 ActionDest: 174 Annotation: Subtype: Link Rect: 118, 65, 130, 54 ActionDest: 174 Annotation: Subtype: Link Rect: 476, 747, 492, 736 ActionDest: 174 Annotation: Subtype: Link Rect: 471, 725, 478, 714 ActionDest: 174 Annotation: Subtype: Link Rect: 391, 345, 504, 334 Annotation: Subtype: Link Rect: 343, 65, 459, 54 Page: Label: 1596 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 152, 692, 159, 681 ActionDest: 174 Annotation: Subtype: Link Rect: 202, 670, 208, 659 ActionDest: 174 Annotation: Subtype: Link Rect: 511, 747, 536, 736 ActionDest: 77 Annotation: Subtype: Link Rect: 306, 736, 427, 725 Annotation: Subtype: Link Rect: 477, 714, 485, 703 ActionDest: 174 Annotation: Subtype: Link Rect: 430, 670, 547, 659 Annotation: Subtype: Link Rect: 475, 625, 553, 614 Annotation: Subtype: Link Rect: 306, 614, 337, 603 Annotation: Subtype: Link Rect: 474, 483, 504, 473 ActionDest: 88 Annotation: Subtype: Link Rect: 527, 483, 553, 473 Annotation: Subtype: Link Rect: 306, 472, 397, 462 Annotation: Subtype: Link Rect: 420, 450, 448, 439 ActionDest: 88 Annotation: Subtype: Link Rect: 470, 450, 553, 439 Annotation: Subtype: Link Rect: 306, 439, 339, 428 Annotation: Subtype: Link Rect: 453, 395, 502, 384 ActionDest: 93 Annotation: Subtype: Link Rect: 309, 373, 350, 362 ActionDest: 93 Annotation: Subtype: Link Rect: 445, 373, 486, 362 ActionDest: 93 Annotation: Subtype: Link Rect: 430, 362, 468, 351 ActionDest: 93 Annotation: Subtype: Link Rect: 520, 284, 550, 273 ActionDest: 88 Annotation: Subtype: Link Rect: 306, 273, 424, 262 Annotation: Subtype: Link Rect: 444, 273, 553, 262 Annotation: Subtype: Link Rect: 306, 262, 316, 251 Annotation: Subtype: Link Rect: 493, 218, 522, 207 ActionDest: 88 Annotation: Subtype: Link Rect: 527, 218, 553, 207 Annotation: Subtype: Link Rect: 306, 207, 399, 196 Annotation: Subtype: Link Rect: 422, 207, 553, 196 Annotation: Subtype: Link Rect: 306, 196, 335, 185 Annotation: Subtype: Link Rect: 466, 162, 528, 152 ActionDest: 93 Annotation: Subtype: Link Rect: 412, 140, 530, 129 Page: Label: 1597 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 158, 142, 184, 131 ActionDest: 88 Annotation: Subtype: Link Rect: 203, 142, 239, 131 ActionDest: 118 Annotation: Subtype: Link Rect: 309, 142, 425, 131 Annotation: Subtype: Link Rect: 507, 271, 511, 262 ActionDest: 174 Page: Label: 1598 Sequence: 5 Page: Label: 1599 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 44, 527, 80, 516 ActionDest: 118 Annotation: Subtype: Link Rect: 99, 527, 215, 516 Annotation: Subtype: Link Rect: 215, 415, 242, 404 ActionDest: 88 Annotation: Subtype: Link Rect: 264, 415, 288, 404 Annotation: Subtype: Link Rect: 42, 404, 131, 393 Annotation: Subtype: Link Rect: 125, 338, 162, 327 ActionDest: 122 Annotation: Subtype: Link Rect: 409, 515, 458, 505 ActionDest: 122 Annotation: Subtype: Link Rect: 491, 229, 528, 218 ActionDest: 126 Annotation: Subtype: Link Rect: 309, 174, 354, 163 ActionDest: 126 Annotation: Subtype: Link Rect: 335, 54, 449, 43 Page: Label: 1600 Sequence: 7 Page: Label: 1601 Sequence: 8 Page: Label: 1602 Sequence: 9 Page: Label: 1603 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 267, 669, 288, 658 ActionDest: 174 Annotation: Subtype: Link Rect: 245, 490, 249, 479 ActionDest: 174 Annotation: Subtype: Link Rect: 236, 434, 261, 423 ActionDest: 174 Annotation: Subtype: Link Rect: 95, 378, 102, 367 ActionDest: 174 Annotation: Subtype: Link Rect: 178, 188, 198, 177 ActionDest: 174 Annotation: Subtype: Link Rect: 197, 110, 200, 99 ActionDest: 174 Annotation: Subtype: Link Rect: 368, 736, 375, 725 ActionDest: 174 Annotation: Subtype: Link Rect: 327, 626, 343, 615 ActionDest: 174 Annotation: Subtype: Link Rect: 392, 516, 412, 505 ActionDest: 174 Annotation: Subtype: Link Rect: 511, 406, 514, 395 ActionDest: 174 Annotation: Subtype: Link Rect: 396, 263, 411, 252 ActionDest: 174 Annotation: Subtype: Link Rect: 328, 142, 332, 131 ActionDest: 174 Page: Label: 1604 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 242, 659, 245, 648 ActionDest: 174 Annotation: Subtype: Link Rect: 245, 615, 248, 604 ActionDest: 174 Annotation: Subtype: Link Rect: 186, 571, 192, 560 ActionDest: 174 Annotation: Subtype: Link Rect: 274, 538, 288, 527 ActionDest: 174 Annotation: Subtype: Link Rect: 282, 505, 288, 494 ActionDest: 174 Annotation: Subtype: Link Rect: 107, 395, 113, 384 ActionDest: 174 Annotation: Subtype: Link Rect: 139, 120, 142, 109 ActionDest: 174 Page: Label: 1605 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 116, 604, 171, 594 Annotation: Subtype: Link Rect: 111, 101, 247, 91 Annotation: Subtype: Link Rect: 113, 75, 228, 65 Annotation: Subtype: Link Rect: 355, 747, 470, 737 Annotation: Subtype: Link Rect: 385, 738, 499, 728 Annotation: Subtype: Link Rect: 358, 729, 472, 719 Annotation: Subtype: Link Rect: 360, 719, 475, 710 Annotation: Subtype: Link Rect: 354, 710, 469, 701 Annotation: Subtype: Link Rect: 344, 701, 459, 692 Annotation: Subtype: Link Rect: 341, 692, 455, 683 Annotation: Subtype: Link Rect: 354, 683, 468, 674 Annotation: Subtype: Link Rect: 345, 674, 460, 665 Annotation: Subtype: Link Rect: 354, 665, 469, 656 Annotation: Subtype: Link Rect: 427, 625, 480, 616 Annotation: Subtype: Link Rect: 471, 607, 524, 598 Annotation: Subtype: Link Rect: 319, 571, 372, 562 Annotation: Subtype: Link Rect: 319, 544, 358, 535 Annotation: Subtype: Link Rect: 462, 526, 531, 517 Annotation: Subtype: Link Rect: 482, 499, 535, 490 Annotation: Subtype: Link Rect: 409, 472, 445, 463 Annotation: Subtype: Link Rect: 368, 453, 384, 445 Annotation: Subtype: Link Rect: 348, 435, 411, 427 Annotation: Subtype: Link Rect: 522, 417, 538, 409 Annotation: Subtype: Link Rect: 458, 399, 474, 391 Annotation: Subtype: Link Rect: 400, 372, 437, 364 Annotation: Subtype: Link Rect: 523, 354, 548, 345 Annotation: Subtype: Link Rect: 319, 345, 355, 336 Annotation: Subtype: Link Rect: 485, 309, 515, 300 Annotation: Subtype: Link Rect: 550, 282, 553, 273 Annotation: Subtype: Link Rect: 319, 273, 375, 264 Annotation: Subtype: Link Rect: 452, 246, 490, 237 Annotation: Subtype: Link Rect: 476, 228, 542, 219 Annotation: Subtype: Link Rect: 473, 201, 511, 192 Annotation: Subtype: Link Rect: 517, 174, 545, 165 Annotation: Subtype: Link Rect: 433, 147, 476, 138 Annotation: Subtype: Link Rect: 425, 129, 488, 120 Annotation: Subtype: Link Rect: 485, 111, 501, 102 Annotation: Subtype: Link Rect: 346, 93, 373, 84 Annotation: Subtype: Link Rect: 319, 75, 337, 66 Checksum: f3b39923 Type: CRC32 Checksum: ca6397bbabc342c3ffe90459a056a8a3 Type: MD5 Checksum: 37fc3a3cc59ba161e1bc952bdd3c228c6e6e5e98 Type: SHA-1 Checksum: f9f15f10c062c887e3401a2a17d2d575959698589d88243812806c50c03e3e99 Type: SHA-256