b7ba0cccd3b8ac2d4bfa93e466b4a9f7 pmc_10654626.pdf 853955d986fb59fa7493042fa937428d2dc638a0 pmc_10654626.pdf fbd3d4aa5bf2e9392b3a1ff8fa0ec5dbb6bf2733a08815407ff01574500639c8 pmc_10654626.pdf Title: Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly Subject: Marques-Pamies M, Gil J, Valassi E, Hernández M, Biagetti B, Giménez-Palop O, Martínez S, Carrato C, Pons L, Villar-Taibo R, Araujo-Castro M, Blanco C, Simón I, Simó-Servat A, Xifra G, Vázquez F, Pavón I, García-Centeno R, Zavala R, Hanzu FA, Mora M, Aulinas A, Vilarrasa N, Librizzi S, Calatayud M, de Miguel P, Alvarez-Escola C, Picó A, Sampedro M, Salinas I, Fajardo-Montañana C, Cámara R, Bernabéu I, Jordà M, Webb SM, Marazuela M and Puig-Domingo M (2023) Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly. Front. Endocrinol. 14:1269787 Keywords: acromegaly, somatostatin analogs, prediction, individualized treatment, precision medicine, acute octreotide test Author: Montserrat Marques-Pamies CreationDate: Tue Oct 31 06:43:58 2023 CET ModDate: Tue Oct 31 06:43:58 2023 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 1441422 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CPBAFB+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 518 0 CPBAJA+AdvPSA18C Type 1C WinAnsi yes yes no 519 0 CPBAJB+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 520 0 CPBAKC+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 525 0 CPBAKD+AdvPSA323 Type 1C WinAnsi yes yes no 526 0 CPBALE+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 527 0 CPBALF+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 530 0 CPBDLD+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 531 0 CPBDOD+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 536 0 CPBEDE+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 238 0 CPBEDF+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 244 0 CPBEDG+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 248 0 CPBECD+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 242 0 CPBECE+AdvTT9b12cd41+22 Type 1C Custom yes yes yes 255 0 CPBEFH+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 260 0 CPBEGH+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 256 0 CPBEHI+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 262 0 CPBELH+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 263 0 CPBELI+AdvTT2cba4af3.B+26 Type 1C Custom yes yes yes 264 0 CPBENJ+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 265 0 HelveticaNeueLTStd-Bd Type 1C WinAnsi yes no no 268 0 CPCNKC+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 274 0 CPCNKD+AdvTT58d178b9+03 Type 1C Custom yes yes yes 272 0 CPCNKE+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 276 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-03-26 02:34:57 CET RepresentationInformation: pmc_10654626.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-03-15 02:37:09 CET Size: 1441422 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 620 FreeObjects: 3 IncrementalUpdates: 3 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly Destination: bmark_1856853160 Children: Item: Title: 1 Introduction Destination: s1 Item: Title: 2 Methods Destination: s2 Children: Item: Title: 2.1 Patients Destination: s2_1 Item: Title: 2.2 Acute octreotide test Destination: s2_2 Item: Title: 2.3 Response criteria Destination: s2_3 Item: Title: 2.4 Magnetic resonance Destination: s2_4 Item: Title: 2.5 Immunohistochemistry Destination: s2_5 Item: Title: 2.6 Hormonal determinations Destination: s2_6 Item: Title: 2.7 Statistical analysis Destination: s2_7 Item: Title: 3 Results Destination: s3 Children: Item: Title: 3.1 sAOT results segregate SRL responders and non-responders Destination: s3_1 Item: Title: 3.2 Correlation of the sAOT variables with basal analytical values and tumor size Destination: s3_2 Item: Title: 3.3 Predictive value of sAOT to the response to SRLs Destination: s3_3 Item: Title: 3.4 Response to the sAOT is associated with tumor expression of E-cadherin and SSTR2 Destination: s3_4 Item: Title: 3.5 Predictive value of basal GH and IGF1 Destination: s3_5 Item: Title: 3.6 Newly diagnosed versus surgically non-cured patients’ response to sAOT Destination: s3_6 Item: Title: 4 Discussion Destination: s4 Item: Title: Data availability statement Destination: s5 Item: Title: Ethics statement Destination: s6 Item: Title: Author contributions Destination: s7 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: References Destination: bmark_2090415954 Info: Title: Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly Author: Montserrat Marques-Pamies Subject: Marques-Pamies M, Gil J, Valassi E, Hernández M, Biagetti B, Giménez-Palop O, Martínez S, Carrato C, Pons L, Villar-Taibo R, Araujo-Castro M, Blanco C, Simón I, Simó-Servat A, Xifra G, Vázquez F, Pavón I, García-Centeno R, Zavala R, Hanzu FA, Mora M, Aulinas A, Vilarrasa N, Librizzi S, Calatayud M, de Miguel P, Alvarez-Escola C, Picó A, Sampedro M, Salinas I, Fajardo-Montañana C, Cámara R, Bernabéu I, Jordà M, Webb SM, Marazuela M and Puig-Domingo M (2023) Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly. Front. Endocrinol. 14:1269787 Keywords: acromegaly, somatostatin analogs, prediction, individualized treatment, precision medicine, acute octreotide test CreationDate: Tue Oct 31 06:43:58 CET 2023 ModDate: Tue Oct 31 06:43:58 CET 2023 ID: 0xfdbe4bee8d6a0c203bdca8edf3f92311, 0x4ae3d13ad80a514e85a7da730dbbe61c Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 3173 ImageHeight: 2879 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1299 ImageHeight: 2098 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 886 ImageHeight: 745 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: 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Silvia Martínez Cristina Carrato Laura Pons Rocío Villar-Taibo Marta Araujo-Castro Concepción Blanco Inmaculada Simón Andreu Simó-Servat Gemma Xifra Federico Vázquez Isabel Pavón Rogelio García-Centeno Roxana Zavala Felicia Alexandra Hanzu Mireia Mora Anna Aulinas Nuria Vilarrasa Soledad Librizzi María Calatayud Paz de Miguel Cristina Alvarez-Escola Antonio Picó Miguel Sampedro Isabel Salinas Carmen Fajardo-Montañana Rosa Cámara Ignacio Bernabéu Mireia Jordà Susan M. Webb Mónica Marazuela Manel Puig-Domingo Marques-Pamies M, Gil J, Valassi E, Hernández M, Biagetti B, Giménez-Palop O, Martínez S, Carrato C, Pons L, Villar-Taibo R, Araujo-Castro M, Blanco C, Simón I, Simó-Servat A, Xifra G, Vázquez F, Pavón I, García-Centeno R, Zavala R, Hanzu FA, Mora M, Aulinas A, Vilarrasa N, Librizzi S, Calatayud M, de Miguel P, Alvarez-Escola C, Picó A, Sampedro M, Salinas I, Fajardo-Montañana C, Cámara R, Bernabéu I, Jordà M, Webb SM, Marazuela M and Puig-Domingo M (2023) Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly. Front. Endocrinol. 14:1269787 Copyright © 2023 Marques-Pamies, Gil, Valassi, Hernández, Biagetti, Giménez-Palop, Martínez, Carrato, Pons, Villar-Taibo, Araujo-Castro, Blanco, Simón, Simó-Servat, Xifra, Vázquez, Pavón, García-Centeno, Zavala, Hanzu, Mora, Aulinas, Vilarrasa, Librizzi, Calatayud, de Miguel, Alvarez-Escola, Picó, Sampedro, Salinas, Fajardo-Montañana, Cámara, Bernabéu, Jordà, Webb, Marazuela and Puig-Domingo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. acromegaly somatostatin analogs prediction individualized treatment precision medicine acute octreotide test Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly acromegaly, somatostatin analogs, prediction, individualized treatment, precision medicine, acute octreotide test True https://www.frontiersin.org/legal/copyright-statement 2023-10-31T13:43:58+08:00 2023-10-31T13:43:58+08:00 2023-10-31T13:43:58+08:00 uuid:46d3c83d-b82b-49a7-bd5e-df6d1d256d11 uuid:03725d68-5c4a-4a45-a8e0-4b55d702c5d0 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 691, 465, 712 Annotation: Subtype: Link Rect: 222, 666, 545, 687 Annotation: Subtype: Link Rect: 222, 641, 522, 662 Annotation: Subtype: Link Rect: 222, 616, 358, 637 Annotation: Subtype: Link Rect: 368, 586, 377, 595 Annotation: Subtype: Link Rect: 432, 586, 441, 595 Annotation: Subtype: 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