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RepresentationInformation: pmc_10666775.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-06-20 02:37:29 CEST Size: 3314024 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 638 FreeObjects: 3 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Zinc deficiency impairs axonal regeneration and functional recovery after spinal cord injury by modulating macrophage polarization via NF-κB pathway Destination: bmark_2039778374 Children: Item: Title: Introduction Destination: s1 Item: Title: Materials and methods Destination: s2 Children: Item: Title: Mice Destination: s2_1 Item: Title: Spinal cord injury Destination: s2_2 Item: Title: Histopathological examination Destination: s2_3 Item: Title: Flow cytometry Destination: s2_4 Item: Title: Quantitative reverse transcription-PCR Destination: s2_5 Item: Title: THP-1 cell culture Destination: s2_6 Item: Title: Statistics Destination: s2_7 Item: Title: Results Destination: s3 Children: Item: Title: Zinc deficiency promotes nuclear translocation of NF-κB in macrophages with change of macrophage phenotype and exacerbates subsequent inflammatory response Destination: s3_1 Item: Title: Zinc regulated NF-&kgr;B activity and subsequent inflammatory response after SCI Destination: s3_2 Item: Title: Zinc supplementation significantly improved axonal regeneration and functional recovery after SCI Destination: s3_3 Item: Title: Discussion Destination: s4 Item: Title: Conclusion Destination: s5 Item: Title: Data availability statement Destination: s6 Item: Title: Ethics statement Destination: s7 Item: Title: Author contributions Destination: s8 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: References Destination: bmark_2090415954 Info: Keywords: spinal cord injury, zinc deficiency, zinc 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FontName: OHMBCJ+AdvTT2c8ce45a Flags: Nonsymbolic FontBBox: -52, -208, 947, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHMBCK+AdvTT9b12cd41+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OHMBCK+AdvTT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: Ken Kijima Gentaro Ono Kazu Kobayakawa Hirokazu Saiwai Masamitsu Hara Shingo Yoshizaki Kazuya Yokota Takeyuki Saito Tetsuya Tamaru Hirotaka Iura Yohei Haruta Kazuki Kitade Takeshi Utsunomiya Daijiro Konno V. Reggie Edgerton Charles Y. Liu Hiroaki Sakai Takeshi Maeda Kenichi Kawaguchi Yoshihiro Matsumoto Seiji Okada Yasuharu Nakashima Kijima K, Ono G, Kobayakawa K, Saiwai H, Hara M, Yoshizaki S, Yokota K, Saito T, Tamaru T, Iura H, Haruta Y, Kitade K, Utsunomiya T, Konno D, Edgerton VR, Liu CY, Sakai H, Maeda T, Kawaguchi K, Matsumoto Y, Okada S and Nakashima Y (2023) Zinc deficiency impairs axonal regeneration and functional recovery after spinal cord injury by modulating macrophage polarization via NF-?B pathway. Front. Immunol. 14:1290100 Copyright © 2023 Kijima, Ono, Kobayakawa, Saiwai, Hara, Yoshizaki, Yokota, Saito, Tamaru, Iura, Haruta, Kitade, Utsunomiya, Konno, Edgerton, Liu, Sakai, Maeda, Kawaguchi, Matsumoto, Okada and Nakashima. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. spinal cord injury zinc deficiency zinc supplementation NF-?B pro-inflammatory like macrophage axonal regeneration Zinc deficiency impairs axonal regeneration and functional recovery after spinal cord injury by modulating macrophage polarization via NF-?B pathway spinal cord injury, zinc deficiency, zinc supplementation, NF-?B, pro-inflammatory like macrophage, axonal regeneration True https://www.frontiersin.org/legal/copyright-statement Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 686, 514, 707 Annotation: Subtype: Link Rect: 222, 661, 492, 682 Annotation: Subtype: Link Rect: 222, 636, 530, 657 Annotation: Subtype: Link Rect: 222, 611, 490, 632 Annotation: Subtype: Link Rect: 222, 586, 524, 607 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 691, 125, 706 Annotation: Subtype: Link 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