9d1af4fb38ba00a324f27da22800eb02 pmc_10670024.pdf 59f8ef74c6a29ab110e058873d7e516cafea1336 pmc_10670024.pdf f1870f8c6ac95a8b9d77deb41880af8e6fc36e3d7a064be3c2872552f30dc6fe pmc_10670024.pdf Title: Evolution of Pharmacological Treatments and Associated Costs for Multiple Myeloma in the Public Healthcare System of Catalonia: A Retrospective Observational Study Subject: (1) Background: Our understanding of and treatment for multiple myeloma (MM) has advanced significantly, and new pharmacological treatments have promising benefits but high price tags. This study analyzes prescription patterns and pharmaceutical expenditure for MM treatments in Catalonia’s public healthcare system over eight years. (2) Methods: A retrospective observational study examined MM treatment data from 2015 to 2022 in Catalonia, using healthcare registries from the Catalan Health Service to collect information on patients, medicines used, and treatment costs. (3) Results: A total of 4556 MM patients received treatment, with a rising trend in the number of treated patients each year from 902 in 2015 to 1899 in 2022. The mean age was 68.9 years, and patients were almost evenly distributed by gender (51.5% male). Most patients were treated with bortezomib (3338 patients), lenalidomide (2952), and/or daratumumab (1093). Most drugs showed increased utilization annually, most significantly for lenalidomide and daratumumab. The total pharmacological treatment cost throughout the entire study period was EUR 321,811,249, with lenalidomide leading with the highest total cost (EUR 157,236,784), and daratumumab exhibiting the highest increase in annual expenditure. (5) Conclusions: The study reveals a progressive increase in the number of MM patients treated and rising pharmaceutical costs. Lenalidomide and daratumumab incurred the highest costs. The findings highlight MM treatment’s economic impact and the need to monitor prescription patterns and expenditures to optimize healthcare resources and decision making. Understanding these trends can guide resource allocation effectively. 20pt Keywords: multiple myeloma; hematological neoplasms; pharmacological treatments; health expenditures; treatment patterns Author: Gemma Garrido-Alejos, Guillem Saborit-Canals, Laura Guarga, Thais de Pando, Miriam Umbria, Albert Oriol, Anna Feliu, Caridad Pontes and Antonio Vallano Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Nov 9 09:57:26 2023 CET ModDate: Thu Nov 9 10:03:32 2023 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1747315 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LYBHLG+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 XNRCCM+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 GYYMHP+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 38 0 PXTEMV+CMSY10 Type 1 Builtin yes yes no 63 0 AMJCGA+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 77 0 AMJANA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 80 0 AMJANB+PalatinoLinotype CID TrueType Identity-H yes yes yes 83 0 AMJANC+PalatinoLinotype TrueType WinAnsi yes yes no 89 0 AMJANE+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 92 0 AMJBGC+PalatinoLinotype TrueType MacRoman yes yes no 95 0 AMJANA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 115 0 AMJANC+PalatinoLinotype TrueType WinAnsi yes yes no 118 0 AMJANE+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 121 0 AMJANA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 140 0 AMJANC+PalatinoLinotype TrueType WinAnsi yes yes no 143 0 AMJANE+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 146 0 IPXDXF+VnURWPalladioL Type 1 Custom yes yes no 172 0 NYDKVC+VnURWPalladioL-Italic Type 1 Custom yes yes no 177 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-04 02:41:46 CEST RepresentationInformation: pmc_10670024.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-24 02:38:54 CEST Size: 1747315 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 362 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Data Source Destination: subsection.2.1 Item: Title: Study Population Destination: subsection.2.2 Item: Title: Outcomes Destination: subsection.2.3 Item: Title: Statistical Analysis Destination: subsection.2.4 Item: Title: Ethics Destination: subsection.2.5 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Evolution of Pharmacological Treatments and Associated Costs for Multiple Myeloma in the Public Healthcare System of Catalonia: A Retrospective Observational Study Author: Gemma Garrido-Alejos, Guillem Saborit-Canals, Laura Guarga, Thais de Pando, Miriam Umbria, Albert Oriol, Anna Feliu, Caridad Pontes and Antonio Vallano Subject: (1) Background: Our understanding of and treatment for multiple myeloma (MM) has advanced significantly, and new pharmacological treatments have promising benefits but high price tags. This study analyzes prescription patterns and pharmaceutical expenditure for MM treatments in Catalonia’s public healthcare system over eight years. (2) Methods: A retrospective observational study examined MM treatment data from 2015 to 2022 in Catalonia, using healthcare registries from the Catalan Health Service to collect information on patients, medicines used, and treatment costs. (3) Results: A total of 4556 MM patients received treatment, with a rising trend in the number of treated patients each year from 902 in 2015 to 1899 in 2022. The mean age was 68.9 years, and patients were almost evenly distributed by gender (51.5% male). Most patients were treated with bortezomib (3338 patients), lenalidomide (2952), and/or daratumumab (1093). Most drugs showed increased utilization annually, most significantly for lenalidomide and daratumumab. The total pharmacological treatment cost throughout the entire study period was EUR 321,811,249, with lenalidomide leading with the highest total cost (EUR 157,236,784), and daratumumab exhibiting the highest increase in annual expenditure. (5) Conclusions: The study reveals a progressive increase in the number of MM patients treated and rising pharmaceutical costs. Lenalidomide and daratumumab incurred the highest costs. The findings highlight MM treatment’s economic impact and the need to monitor prescription patterns and expenditures to optimize healthcare resources and decision making. 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