25d69e152b377f8765488f9eb8b8b600 pmc_10675133.pdf 952714a90e89686f83338af234dab4a0a16cb40f pmc_10675133.pdf 159d57319c06fe94c57baa7e16cd8147bf3df089bdc7f81c553749bbf2824efd pmc_10675133.pdf Title: A Profile of Adult Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia Patients According to Pneumococcal Vaccination Status Subject: Certain patient profile characteristics, such as preexisting medical conditions, can modify the risk of developing SARS-CoV-2 pneumonia among adults vaccinated and not vaccinated against pneumococcal disease. This retrospective cohort study aimed to quantify the risk of pneumonia caused by SARS-CoV-2 among individuals from 15 to 64 years old with and without pneumococcal vaccination in Spain during the 2020–2021 influenza season and establish a risk profile of patients more likely to develop SARS-CoV-2 pneumonia. Data (demographic information, patient medical history, and lifestyle habits) were gathered both directly from the patient via personal interview and by reviewing electronic medical records. In an adjusted analysis for pneumococcal vaccinated patients, visits to hospital outpatient clinics were protective while visits to primary health care services, being widowed, obese, and not using masks in outdoor open spaces were identified as risk factors. For patients who had not received a pneumococcal vaccine, visits to hospital outpatient clinics were protective, while being overweight or obese, alcohol consumption, and not using masks in outdoor open spaces were identified as risk factors. Concerning comorbidities, in the pneumococcal vaccinated group none were found to be protective but having diabetes or other respiratory diseases were identified as risk factors. In the unvaccinated group, undergoing immunosuppressive treatment and having metastatic tumors were protective factors, while cerebrovascular disease and obesity with a BMI 40 were risk factors. A similar risk profile for developing SARS-CoV-2 pneumonia in pneumococcal vaccinated and non-vaccinated individuals was found. Generally, vaccinated individuals had a lower risk of developing SARS-CoV-2. The findings suggest that vaccination against S. pneumoniae could prevent and reduce SARS-CoV-2 pneumonia. Additionally, this study has identified individuals with other medical conditions, such as obesity, underweight, diabetes, and a history of respiratory diseases, who are at an increased risk of developing SARS-CoV-2 pneumonia and could benefit from vaccination and supervision. Keywords: SARS-CoV-2 pneumonia; Streptococcus pneumoniae; pneumococcal vaccine Author: María Morales-Suárez-Varela, Diana Toledo, María Amelia Fernández-Sierra, María Liébana, Gerardo Rubiera, Gema Navarro, Concepción Prados, Judith Chamarro, Isabel Peraita-Costa, Angela Domínguez and Working Group of Project FIS PI19/00354 Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Oct 24 13:39:22 2023 CEST ModDate: Tue Oct 24 15:00:07 2023 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 21 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1008879 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IYDCBB+VnURWPalladioL Type 1 Custom yes yes no 10 0 EHHUYG+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 UPDING+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 LAIUMO+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 ZYGMNY+CMSY10 Type 1 Builtin yes yes no 28 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 78 0 PJDGMM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 112 0 PJDGMO+PalatinoLinotype TrueType WinAnsi yes yes no 115 0 PJDGNA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 118 0 PJDHJN+PalatinoLinotype TrueType MacRoman yes yes no 121 0 PJDGMM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 143 0 PJDGMO+PalatinoLinotype TrueType WinAnsi yes yes no 146 0 PJDGNA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 149 0 PJDHJN+PalatinoLinotype TrueType MacRoman yes yes no 152 0 RIJDHR+CMBSY10 Type 1 Builtin yes yes no 178 0 PJDGMM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 196 0 PJDGMN+PalatinoLinotype CID TrueType Identity-H yes yes yes 199 0 PJDGMO+PalatinoLinotype TrueType WinAnsi yes yes no 205 0 PJDGNA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 208 0 PJDHJN+PalatinoLinotype TrueType MacRoman yes yes no 211 0 PJDGMM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 227 0 PJDGMN+PalatinoLinotype CID TrueType Identity-H yes yes yes 230 0 PJDGMO+PalatinoLinotype TrueType WinAnsi yes yes no 236 0 PJDGNA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 239 0 PJDHJN+PalatinoLinotype TrueType MacRoman yes yes no 242 0 NJWNDJ+VnURWPalladioL-Italic Type 1 Custom yes yes no 256 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-06-18 02:41:43 CEST RepresentationInformation: pmc_10675133.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-06-12 02:48:55 CEST Size: 1008879 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 370 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Design and Study Population Destination: subsection.2.1 Children: Item: Title: Patient Selection Destination: subsubsection.2.1.1 Item: Title: SARS-CoV-2 Pneumonia Inclusion Criteria Destination: subsubsection.2.1.2 Item: Title: SARS-CoV-2 Pneumonia Exclusion Criteria Destination: subsubsection.2.1.3 Item: Title: Data Analysis Destination: subsection.2.2 Item: Title: Results Destination: section.3 Children: Item: Title: Sociodemographic and Health-Related Variables Destination: subsection.3.1 Item: Title: Comorbidities Destination: subsection.3.2 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: A Profile of Adult Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia Patients According to Pneumococcal Vaccination Status Author: María Morales-Suárez-Varela, Diana Toledo, María Amelia Fernández-Sierra, María Liébana, Gerardo Rubiera, Gema Navarro, Concepción Prados, Judith Chamarro, Isabel Peraita-Costa, Angela Domínguez and Working Group of Project FIS PI19/00354 Subject: Certain patient profile characteristics, such as preexisting medical conditions, can modify the risk of developing SARS-CoV-2 pneumonia among adults vaccinated and not vaccinated against pneumococcal disease. This retrospective cohort study aimed to quantify the risk of pneumonia caused by SARS-CoV-2 among individuals from 15 to 64 years old with and without pneumococcal vaccination in Spain during the 2020 2021 influenza season and establish a risk profile of patients more likely to develop SARS-CoV-2 pneumonia. Data (demographic information, patient medical history, and lifestyle habits) were gathered both directly from the patient via personal interview and by reviewing electronic medical records. In an adjusted analysis for pneumococcal vaccinated patients, visits to hospital outpatient clinics were protective while visits to primary health care services, being widowed, obese, and not using masks in outdoor open spaces were identified as risk factors. For patients who had not received a pneumococcal vaccine, visits to hospital outpatient clinics were protective, while being overweight or obese, alcohol consumption, and not using masks in outdoor open spaces were identified as risk factors. Concerning comorbidities, in the pneumococcal vaccinated group none were found to be protective but having diabetes or other respiratory diseases were identified as risk factors. In the unvaccinated group, undergoing immunosuppressive treatment and having metastatic tumors were protective factors, while cerebrovascular disease and obesity with a BMI 40 were risk factors. A similar risk profile for developing SARS-CoV-2 pneumonia in pneumococcal vaccinated and non-vaccinated individuals was found. Generally, vaccinated individuals had a lower risk of developing SARS-CoV-2. The findings suggest that vaccination against S. pneumoniae could prevent and reduce SARS-CoV-2 pneumonia. Additionally, this study has identified individuals with other medical conditions, such as obesity, underweight, diabetes, and a history of respiratory diseases, who are at an increased risk of developing SARS-CoV-2 pneumonia and could benefit from vaccination and supervision. 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