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Title:           aSynPEP-DB: a database of biogenic peptides for inhibiting $\upalpha $-synuclein aggregation
Subject:         DOI: https://doi.org/10.1093/database/baad084, Database, 00, 00, Published xx xxx xxx. Abstract: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, yet effective treatments able to stop or delay disease progression remain elusive. The aggregation of a presynaptic protein, α-synuclein (aSyn), is the primary neurological hallmark of PD and, thus, a promising target for therapeutic intervention. However, the lack of consensus on the molecular properties required to specifically bind the toxic species formed during aSyn aggregation has hindered the development of therapeutic molecules. Recently, we defined and experimentally validated a peptide architecture that demonstrated high affinity and selectivity in binding to aSyn toxic oligomers and fibrils, effectively preventing aSyn pathogenic aggregation. Human peptides with such properties may have neuroprotective activities and hold a huge therapeutic interest. Driven by this idea, here, we developed a discr
Keywords:        
Author:          Carlos Pintado-Grima,Oriol B"00E1rcenas,Valentín Iglesias,Jaime Santos,Zoe Manglano-Artuñedo,Irantzu Pallarès,Michał Burdukiewicz, Salvador Ventura
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     Item: 
      Title: aSynPEP-DB: a database of biogenic peptides for inhibiting α-synuclein aggregation
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        Title:  Introduction
       Item: 
        Title:  Methods
        Children: 
         Item: 
          Title:  Dataset generation
         Item: 
          Title:  Discriminative algorithm for screening peptide candidates
         Item: 
          Title:  Additional predicted features
         Item: 
          Title:  Database implementation
       Item: 
        Title:  Results
        Children: 
         Item: 
          Title:  aSynPEP-DB
         Item: 
          Title:  Case studies
          Children: 
           Item: 
            Title:  A human endogenous neuropeptide: the neuropeptide Y
           Item: 
            Title:  The food-derived bioactive BMAP-28 peptide
           Item: 
            Title:  The human antimicrobial lactoferricin-H peptide
           Item: 
            Title:  The gut-microbiome peptide OR-7
       Item: 
        Title:  Discussion
       Item: 
        Title: Supplementary Material
       Item: 
        Title:  Data availability
       Item: 
        Title: Contribution statement
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        Title: Funding
       Item: 
        Title: Conflict of interest statement
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
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