9814bbdf4bbb803e9b5e3f39e1857a8c pmc_10707177.pdf b0e68df6c5dd7a4b2dd4da855d8b70eaa18d9e85 pmc_10707177.pdf 736cef9d969a906f579756bd8a7836d9ac57f3ccfdc5c4b9174705024571d7af pmc_10707177.pdf Title: Splanchnic Vein Thrombosis in Inflammatory Bowel Disease: An Observational Study from the ENEIDA Registry and Systematic Review Subject: Background: Thromboembolic events are frequent among patients with inflammatory bowel disease (IBD). However, there is little information on the prevalence, features and outcomes of splanchnic vein thrombosis (SVT) in patients with IBD. Aims: To describe the clinical features and outcomes of SVT in patients with IBD and to perform a systematic review of these data with published cases and series. Methods: A retrospective observational study from the Spanish nationwide ENEIDA registry was performed. A systematic search of the literature was performed to identify studies with at least one case of SVT in IBD patients. Results: A new cohort of 49 episodes of SVT from the Eneida registry and 318 IBD patients with IBD identified from the literature review (sixty studies: two multicentre, six single-centre and fifty-two case reports or case series) were analysed. There was a mild predominance of Crohn’s disease and the most frequent clinical presentation was abdominal pain with or without fever followed by the incidental finding in cross-sectional imaging techniques. The most frequent SVT location was the main portal trunk in two-thirds of the cases, followed by the superior mesenteric vein. Anticoagulation therapy was prescribed in almost 90% of the cases, with a high rate of radiologic resolution of SVT. Thrombophilic conditions other than IBD itself were found in at least one-fifth of patients. Conclusions: SVT seems to be a rare (or underdiagnosed) complication in IBD patients. SVT is mostly associated with disease activity and evolves suitably when anticoagulation therapy is started. Keywords: prevalence; splanchnic vein thrombosis; inflammatory bowel disease; outcome Author: Maria Puig, Helena Masnou, Francisco Mesonero, Luís Menchén, Luís Bujanda, Jesús Castro, Irene González-Partida, Raquel Vicente, Carlos González-Muñoza, Marisa Iborra, Mónica Sierra, José María Huguet, María José García, Ruth De Francisco, Francisco Javier García-Alonso, Míriam Mañosa, Eugeni Domènech and on behalf of ENEIDA-GETECCU Registry Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Nov 28 10:57:00 2023 CET ModDate: Tue Nov 28 11:11:50 2023 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 865608 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SXQPWE+VnURWPalladioL Type 1 Custom yes yes no 10 0 UKORBL+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 GXEPZU+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 ZITBHC+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 NRWICF+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 49 0 PNGTLU+URWPalladioL-BoldItal Type 1 Custom yes yes no 77 0 POHEHP+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 99 0 POHEJB+PalatinoLinotype TrueType WinAnsi yes yes no 102 0 POHEJD+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 105 0 POHFED+PalatinoLinotype TrueType MacRoman yes yes no 119 0 POHEHP+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 122 0 POHEJB+PalatinoLinotype TrueType WinAnsi yes yes no 125 0 POHEJD+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 128 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-03 02:40:41 CEST RepresentationInformation: pmc_10707177.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-24 02:38:44 CEST Size: 865608 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 361 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Patients and Methods Destination: section.2 Children: Item: Title: Patients Destination: subsection.2.1 Item: Title: Data Collection Destination: subsection.2.2 Item: Title: Statistical Analysis Destination: subsection.2.3 Item: Title: Systematic Review Destination: subsection.2.4 Item: Title: Data Collection and Analysis Destination: subsection.2.5 Item: Title: Results Destination: section.3 Children: Item: Title: ENEIDA Cohort Destination: subsection.3.1 Item: Title: Systematic Review Destination: subsection.3.2 Item: Title: Discussion Destination: section.4 Item: Title: Appendix A Destination: section.A. Item: Title: References Destination: section.B. Info: Title: Splanchnic Vein Thrombosis in Inflammatory Bowel Disease: An Observational Study from the ENEIDA Registry and Systematic Review Author: Maria Puig, Helena Masnou, Francisco Mesonero, Luís Menchén, Luís Bujanda, Jesús Castro, Irene González-Partida, Raquel Vicente, Carlos González-Muñoza, Marisa Iborra, Mónica Sierra, José María Huguet, María José García, Ruth De Francisco, Francisco Javier García-Alonso, Míriam Mañosa, Eugeni Domènech and on behalf of ENEIDA-GETECCU Registry Subject: Background: Thromboembolic events are frequent among patients with inflammatory bowel disease (IBD). However, there is little information on the prevalence, features and outcomes of splanchnic vein thrombosis (SVT) in patients with IBD. Aims: To describe the clinical features and outcomes of SVT in patients with IBD and to perform a systematic review of these data with published cases and series. Methods: A retrospective observational study from the Spanish nationwide ENEIDA registry was performed. A systematic search of the literature was performed to identify studies with at least one case of SVT in IBD patients. Results: A new cohort of 49 episodes of SVT from the Eneida registry and 318 IBD patients with IBD identified from the literature review (sixty studies: two multicentre, six single-centre and fifty-two case reports or case series) were analysed. There was a mild predominance of Crohn’s disease and the most frequent clinical presentation was abdominal pain with or without fever followed by the incidental finding in cross-sectional imaging techniques. The most frequent SVT location was the main portal trunk in two-thirds of the cases, followed by the superior mesenteric vein. Anticoagulation therapy was prescribed in almost 90% of the cases, with a high rate of radiologic resolution of SVT. Thrombophilic conditions other than IBD itself were found in at least one-fifth of patients. Conclusions: SVT seems to be a rare (or underdiagnosed) complication in IBD patients. SVT is mostly associated with disease activity and evolves suitably when anticoagulation therapy is started. 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