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Keywords:       COVID-19, SARS-CoV-2, vaccine, neutralizing antibodies, humoral response, Spike glycoprotein
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      Title: Novel Spike-stabilized trimers with improved production protect K18-hACE2 mice and golden Syrian hamsters from the highly pathogenic SARS-CoV-2 Beta variant
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        Title: 1 Introduction
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        Title: 2 Materials and methods
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          Title: 2.1 Recombinant trimeric S glycoprotein design and modeling
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          Title: 2.2 Recombinant protein production and purification
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          Title: 2.3 Recombinant S proteins quantification and RBD exposure
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          Title: 2.4 Viral stock preparation
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          Title: 2.5 In vivo immunization and challenge experiments
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          Title: 2.6 Quantification of anti-S and anti-RBD antibodies by ELISA
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          Title: 2.7 Neutralizing activity of serum samples
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          Title: 2.8 Viral load quantification in oropharyngeal swab and tissue samples
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          Title: 2.9 Pathology and immunohistochemistry
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        Title: 3 Results
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          Title: 3.1 Strategy for S glycoprotein stabilization
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          Title: 3.2 S-21 and S-29 vaccination protects K18-hACE2 mice from SARS-CoV-2-induced disease
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          Title: 3.3 S-21 and S-29 trimer vaccination protects golden Syrian hamsters from COVID-19 development
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        Title: 4 Discussion
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        Title: Data availability statement
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        Title: Ethics statement
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        Title: Author contributions
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        Title: Conflict of interest
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        Title: Supplementary material
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   Type: CRC32
  Checksum: 7ff7c9d4885691b36b8ade7bd164bf97
   Type: MD5
  Checksum: 8f7d464013fdeb8a4cc6fa3e9b58c1ed10a7e785
   Type: SHA-1
  Checksum: eca0d6cf7f0873a459fde78eca2b3bec8061fedf5d40a4ecdcbcdc07aa35ad40
   Type: SHA-256