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Title:           USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder
Subject:         Nature Communications, doi:10.1038/s41467-023-44120-2
Keywords:        
Author:          Julian Cheron
Creator:         Springer
Producer:        iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
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     Item: 
      Title: USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder
      Destination: title_link
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       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: Maged1 expression in Vglut2 neurons, and specifically in the paraventricular thalamus, is necessary and sufficient for cocaine-related behaviors
          Destination: B1
         Item: 
          Title: Cocaine-induced transcriptomic changes involve the Maged1-mediated Polycomb repressive complex
          Destination: B2
         Item: 
          Title: Maged1 enables interaction between histone H2A and’USP7
          Destination: B3
         Item: 
          Title: Cocaine induces an increase of histone H2A monoubiquitination in the NAc, PFC, and thalamus
          Destination: B4
         Item: 
          Title: USP7 pharmacological inhibition or Maged1 inactivation precludes cocaine-evoked H2A monoubiquitination and cocaine sensitization
          Destination: B5
         Item: 
          Title: Cocaine-evoked histone H2A monoubiquitination and its subsequent transcriptional repression
          Destination: B6
         Item: 
          Title: MAGED1-USP7 modifies addiction risk and behavioral response to cocaine in’humans
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       Item: 
        Title: Discussion
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       Item: 
        Title: Methods
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        Children: 
         Item: 
          Title: Animals
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         Item: 
          Title: Genotyping
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         Item: 
          Title: AAV stereotaxic injections
          Destination: B10
         Item: 
          Title: Cocaine-induced locomotor sensitization
          Destination: B11
         Item: 
          Title: Cocaine-induced CPP and operant self-administration
          Destination: B12
         Item: 
          Title: Immunohistochemistry
          Destination: B13
         Item: 
          Title: In situ hybridization autoradiography
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         Item: 
          Title: Fluorescent In situ hybridization with RNAscope
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         Item: 
          Title: Flow cytometry and cell sorting
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         Item: 
          Title: Transcriptome analyses
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         Item: 
          Title: Protein extraction
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         Item: 
          Title: Immunoprecipitation with mouse lysates
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         Item: 
          Title: Mass spectrometry from mouse lysates
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         Item: 
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         Item: 
          Title: Human cell’lines
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          Title: Immunoprecipitation from human’cells
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         Item: 
          Title: Mass spectrometry from human’cells
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         Item: 
          Title: USP7 inhibition and in’vivo cannula infusion
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         Item: 
          Title: ChIPmentation
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         Item: 
          Title: H2Aub enrichment analysis
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         Item: 
          Title: Gene ontology and curated gene set analysis
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         Item: 
          Title: Statistics and reproducibility
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         Item: 
          Title: Human genotyping, sample selection and clinical assessment
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         Item: 
          Title: Biological sampling and genetic analyses
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         Item: 
          Title: Human SNP-based data analysis
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         Item: 
          Title: Reporting summary
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       Item: 
        Title: Data availability
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       Item: 
        Title: References
        Destination: A4
       Item: 
        Title: Acknowledgements
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       Item: 
        Title: Author contributions
        Destination: A6
       Item: 
        Title: Competing interests
        Destination: A7
       Item: 
        Title: Additional information
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    Title: USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder
    Author: Julian Cheron
    Subject: Nature Communications, doi:10.1038/s41467-023-44120-2
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
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