aaf22f85645693b7236b8ce3de772633 pmc_10735304.pdf b7b0b5c95392f3bbe6f2b3490f32a8e33cdb3512 pmc_10735304.pdf 88f6b9c6a8d99f263db1d8f91af9b463afd318911267f8a600d281722c73484c pmc_10735304.pdf Title: Late gadolinium enhancement distribution patterns in non-ischaemic dilated cardiomyopathy: genotype–phenotype correlation Subject: DOI: 10.1093/ehjci/jead184; European Heart Journal - Cardiovascular Imaging, 25, 1, 2023-08-10.; Abstract: Aims: Late gadolinium enhancement (LGE) is frequently found in patients with dilated cardiomyopathy (DCM); there is little information about its frequency and distribution pattern according to the underlying genetic substrate. We sought to describe LGE patterns according to genotypes and to analyse the risk of major ventricular arrhythmias (MVA) according to patterns. Methods and results: Cardiac magnetic resonance findings and LGE distribution according to genetics were performed in a cohort of 600 DCM patients followed at 20 Spanish centres. After exclusion of individuals with multiple causative gene variants or with variants in infrequent DCM-causing genes, 577 patients (34% females, mean age 53.5 years, left ventricular ejection fraction 36.9 ± 13.9%) conformed to the final cohort. A causative genetic variant was identified in 219 (38%) patients, and 147 (25.5%) had LGE. Si Keywords: dilated cardiomyopathy; late gadolinium enhancement; cardiac magnetic resonance; genetics; sudden cardiac death Author: Fernando de Frutos Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64) CreationDate: Fri Dec 15 09:03:20 2023 CET ModDate: Wed Dec 20 13:07:29 2023 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 2936350 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AQIJAO+CaeciliaLTStd-Roman Type 1C Custom yes yes yes 1729 0 TMPXTC+GillSansNova-Bold CID TrueType Identity-H yes yes yes 1732 0 QEVSUO+GillSansNova-Book CID TrueType Identity-H yes yes yes 1735 0 EQVVPM+GillSansNova-BookItalic CID TrueType Identity-H yes yes yes 1738 0 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secjead184-s1.3 Item: Title: Outcomes Destination: secjead184-s1.4 Item: Title: Statistical analyses Destination: secjead184-s1.5 Item: Title: Results Destination: secjead184-s2 Children: Item: Title: Study participants and baseline characteristics Destination: secjead184-s2.1 Item: Title: CMR measurements Destination: secjead184-s2.2 Item: Title: LGE distribution Destination: secjead184-s2.3 Item: Title: LGE presence according to LVEF Destination: secjead184-s2.4 Item: Title: Yield of genetic testing based on LGE patterns Destination: secjead184-s2.5 Item: Title: Events by LGE patterns Destination: secjead184-s2.6 Item: Title: Discussion Destination: secjead184-s3 Children: Item: Title: Clinical implications Destination: secjead184-s3.1 Item: Title: Limitations Destination: secjead184-s3.2 Item: Title: Conclusion Destination: secjead184-s4 Item: Title: Supplementary data Destination: secjead184-s5 Item: Title: Funding Destination: secjead184-s6 Item: Title: Data availability 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uuid:2B8E71D5-CFDC-F0E3-DC2C-D570438A2D61 True dilated cardiomyopathy; late gadolinium enhancement; cardiac magnetic resonance; genetics; sudden cardiac death PDFlib+PDI 9.0.7p3 (C++/Win64) application/pdf 10.1093/ehjci/jead184 en Oxford University Press Late gadolinium enhancement distribution patterns in non-ischaemic dilated cardiomyopathy: genotype–phenotype correlation Fernando de Frutos Juan Pablo Ochoa Ana Isabel Fernández María Gallego-Delgado Marina Navarro-Peñalver Guillem Casas María Teresa Basurte José María Larrañaga-Moreira María Victoria Mogollón Ainhoa Robles-Mezcua Pablo Elpidio García-Granja Vicente Climent Julián Palomino-Doza Ana García-Álvarez María Brion Ramón Brugada Juan Jiménez-Jáimez Antoni Bayes-Genis Tomas Ripoll-Vera María Luisa Peña-Peña José F. Rodríguez-Palomares Josefa Gonzalez-Carrillo Eduardo Villacorta Maria Angeles Espinosa Pablo Garcia-Pavia Jesus G. Mirelis DOI: 10.1093/ehjci/jead184; European Heart Journal - Cardiovascular Imaging, 25, 1, 2023-08-10.; Abstract: Aims: Late gadolinium enhancement (LGE) is frequently found in patients with dilated cardiomyopathy (DCM); there is little information about its frequency and distribution pattern according to the underlying genetic substrate. We sought to describe LGE patterns according to genotypes and to analyse the risk of major ventricular arrhythmias (MVA) according to patterns. Methods and results: Cardiac magnetic resonance findings and LGE distribution according to genetics were performed in a cohort of 600 DCM patients followed at 20 Spanish centres. After exclusion of individuals with multiple causative gene variants or with variants in infrequent DCM-causing genes, 577 patients (34% females, mean age 53.5 years, left ventricular ejection fraction 36.9 ± 13.9%) conformed to the final cohort. A causative genetic variant was identified in 219 (38%) patients, and 147 (25.5%) had LGE. Si © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. dilated cardiomyopathy late gadolinium enhancement cardiac magnetic resonance genetics sudden cardiac death Journal European Heart Journal - Cardiovascular Imaging © The Author(s) 2023. 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