bbd29ccf98e56ece82141921da5623b5 pmc_10745891.pdf 30bfc3391cf4762335de8b9b826540b22b10a17a pmc_10745891.pdf a7b0a8f3cc8cb118d37293f622c4bcb73fc4d4635a358151c054f657bca4d316 pmc_10745891.pdf Title: Vascular and Platelet Effects of Tomato Soffritto Intake in Overweight and Obese Subjects Subject: Tomatoes are known for their numerous health benefits, including antioxidants, anti-cancer, antimicrobial, anti-inflammatory, anti-neurodegenerative, antiplatelet, and cardio-protective properties. However, their potential health benefits in the Mediterranean diet’s popular soffritto remain largely unexplored in scientific research. The objective was to evaluate the effects of soffritto intake on platelet activity, vascular endothelial function, weight, lipid profile, and blood parameters. In a prospective, controlled, randomized two-arm longitudinal cross-over trial, 40 overweight and obese individuals received 100 g/day of soffritto, or a control, for 42 days. The primary outcome was the effect on vascular endothelial function and platelet activity. As exploratory secondary outcomes, anthropometric measures, serum lipid profile, and hemogram profile were measured before and after a 6-week intervention with or without soffritto supplementation. Compared with the control group, soffritto supplementation for six weeks improved collagen-induced (-5.10 3.06%) platelet aggregation (p < 0.05). In addition, after six weeks, a reduction in ADP-induced aggregation (-3.67 1.68%) was also only observed in the soffritto group (p < 0.05). No significant effects of the soffritto intake were observed on vascular endothelial function, anthropometric measures, serum lipid profile, or blood parameters (p > 0.05). In conclusion, as a basic culinary technique, soffritto may have a role in the primary prevention of cardiovascular disease by reducing platelet activation, which could contribute to a reduction in thrombotic events. Keywords: dietary antiplatelet; lipid profile; endothelial activation; cardiovascular disease; Mediterranean diet Author: Anallely López-Yerena, Teresa Padro, Victoria de Santisteban Villaplana, Natàlia Muñoz-García, Antonio Pérez, Gemma Vilahur and Lina Badimon Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Dec 13 06:24:34 2023 CET ModDate: Wed Dec 13 06:32:33 2023 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1269914 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- TWJYWV+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 IMMOGI+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 LHAVCI+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 QMDDXF+CMSY10 Type 1 Builtin yes yes no 23 0 AWHDWW+VnURWPalladioL Type 1 Custom yes yes no 27 0 ZSBPMM+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 HGMNRX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 50 0 ALMJEC+EURM10 Type 1 Builtin yes yes no 76 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 84 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 88 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 92 0 BCDHEE+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 96 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 103 0 BCDJEE+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 110 0 ZPGVCH+CMEX10 Type 1 Builtin yes yes no 125 0 JHYTSG+CMR10 Type 1 Builtin yes yes no 129 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 144 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 148 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 152 0 BCDHEE+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 156 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 163 0 BCDJEE+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 170 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 183 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 187 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 191 0 BCDHEE+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 195 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 202 0 BCDJEE+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 209 0 BCDLEE+PalatinoLinotype-BoldItalic CID TrueType Identity-H yes yes yes 216 0 PDXFNG+PazoMath-Bold Type 1 Builtin yes yes no 229 0 QFBPDK+URWPalladioL-BoldItal Type 1 Custom yes yes no 233 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-01 02:42:40 CEST RepresentationInformation: pmc_10745891.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-24 02:38:25 CEST Size: 1269914 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 459 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Subjects Destination: subsection.2.1 Item: Title: Ethics Statement Destination: subsection.2.2 Item: Title: Soffritto Samples Destination: subsection.2.3 Item: Title: Study Design and Dietary Monitoring Destination: subsection.2.4 Item: Title: Outcomes Destination: subsection.2.5 Children: Item: Title: Platelet Aggregation Destination: subsubsection.2.5.1 Item: Title: Flow Cytometric Analysis of Circulating Extracellular Vesicles Destination: subsubsection.2.5.2 Item: Title: Anthropometric Data, Blood Pressure, Lipid Profile, and Other Biochemical Measurements Destination: subsubsection.2.5.3 Item: Title: Vascular Endothelial Function and Hemogram Profile Destination: subsubsection.2.5.4 Item: Title: Statistical Analysis Destination: subsection.2.6 Item: Title: Results Destination: section.3 Children: Item: Title: Platelet Function Destination: subsection.3.1 Item: Title: Endothelial Function Destination: subsection.3.2 Item: Title: Anthropometric and Biochemical Variables Destination: subsection.3.3 Item: Title: Lipid Profile Destination: subsection.3.4 Item: Title: Blood Parameters Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.A. Info: Title: Vascular and Platelet Effects of Tomato Soffritto Intake in Overweight and Obese Subjects Author: Anallely López-Yerena, Teresa Padro, Victoria de Santisteban Villaplana, Natàlia Muñoz-García, Antonio Pérez, Gemma Vilahur and Lina Badimon Subject: Tomatoes are known for their numerous health benefits, including antioxidants, anti-cancer, antimicrobial, anti-inflammatory, anti-neurodegenerative, antiplatelet, and cardio-protective properties. However, their potential health benefits in the Mediterranean diet’s popular soffritto remain largely unexplored in scientific research. The objective was to evaluate the effects of soffritto intake on platelet activity, vascular endothelial function, weight, lipid profile, and blood parameters. In a prospective, controlled, randomized two-arm longitudinal cross-over trial, 40 overweight and obese individuals received 100 g/day of soffritto, or a control, for 42 days. The primary outcome was the effect on vascular endothelial function and platelet activity. As exploratory secondary outcomes, anthropometric measures, serum lipid profile, and hemogram profile were measured before and after a 6-week intervention with or without soffritto supplementation. Compared with the control group, soffritto supplementation for six weeks improved collagen-induced (-5.10 3.06%) platelet aggregation (p < 0.05). In addition, after six weeks, a reduction in ADP-induced aggregation (-3.67 1.68%) was also only observed in the soffritto group (p < 0.05). No significant effects of the soffritto intake were observed on vascular endothelial function, anthropometric measures, serum lipid profile, or blood parameters (p > 0.05). In conclusion, as a basic culinary technique, soffritto may have a role in the primary prevention of cardiovascular disease by reducing platelet activation, which could contribute to a reduction in thrombotic events. 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