5357e7c7ede4dd8bb638b9edfe691d70 pmc_10761448.pdf d6c4aef55cb596fc81352a9da9e6f05a14b38ed4 pmc_10761448.pdf b5045380705d2a74a514c68741ac6be3d990806449ca29c22249f39e005986b1 pmc_10761448.pdf Title: Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries Subject: Archives of Toxicology, https://doi.org/10.1007/s00204-023-03630-0 Keywords: Drug-induced liver injury; Drug reaction with eosinophilia and systemic symptoms; Severe cutaneous adverse reaction; Hepatotoxicity; Hypersensitivity features Author: Inmaculada Medina-Cáliz Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Sun Dec 3 18:14:30 2023 CET ModDate: Thu Dec 21 12:12:45 2023 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 23 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 645929 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-SemiCn Type 1C WinAnsi yes no yes 489 0 MyriadPro-Semibold Type 1C Custom yes no yes 484 0 MyriadPro-SemiboldSemiCn Type 1C Custom yes no yes 485 0 MyriadPro-Bold Type 1C Custom yes no yes 499 0 QERBKH+STIX-Regular Type 1C Custom yes yes yes 498 0 Springnew-Regular Type 1C WinAnsi yes no yes 518 0 MyriadPro-BoldSemiCn Type 1C Custom yes no yes 256 0 STIX-Italic Type 1C WinAnsi yes no yes 262 0 MRXQCB+Wingdings-Regular Type 1C WinAnsi yes yes yes 387 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-01 02:42:36 CEST RepresentationInformation: pmc_10761448.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-24 02:38:15 CEST Size: 645929 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 563 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Methods Children: Item: Title: Study population Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: Demographics, clinical characteristics, and outcome of DILI-DRESS and DILI cases Item: Title: Prognostic factors in DILI-DRESS cases Item: Title: Causative agents Item: Title: Discussion Item: Title: Anchor 12 Item: Title: References Info: Title: Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries Author: Inmaculada Medina-Cáliz Subject: Archives of Toxicology, https://doi.org/10.1007/s00204-023-03630-0 Keywords: Drug-induced liver injury; Drug reaction with eosinophilia and systemic symptoms; Severe cutaneous adverse reaction; Hepatotoxicity; Hypersensitivity features Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Sun Dec 03 18:44:30 CET 2023 ModDate: Thu Dec 21 12:42:45 CET 2023 ID: 0xf619fe25c75c1d4ea8871856d36b3d04, 0x055197013ca94247bccf689c8cbe3884 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: MyriadPro-BoldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-BoldSemiCn Flags: Nonsymbolic FontBBox: -133, -250, 1161, 894 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: QERBKH+STIX-Regular FontSubset: true FirstChar: 25 LastChar: 250 FontDescriptor: FontName: QERBKH+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MRXQCB+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MRXQCB+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-SemiboldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldSemiCn Flags: Nonsymbolic FontBBox: -131, -250, 1115, 886 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: STIX-Italic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: STIX-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiCn Flags: Nonsymbolic FontBBox: -128, -250, 1059, 876 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true XMP: 2023-12-03T22:44:30+05:30 Springer 2023-12-21T16:42:45+05:30 2023-12-21T16:42:45+05:30 Acrobat Distiller 10.1.8 (Windows) Drug-induced liver injury; Drug reaction with eosinophilia and systemic symptoms; Severe cutaneous adverse reaction; Hepatotoxicity; Hypersensitivity features application/pdf https://doi.org/10.1007/s00204-023-03630-0 Springer Berlin Heidelberg Archives of Toxicology, https://doi.org/10.1007/s00204-023-03630-0 Drug-induced liver injury Drug reaction with eosinophilia and systemic symptoms Severe cutaneous adverse reaction Hepatotoxicity Hypersensitivity features Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries Inmaculada Medina-Cáliz Judith Sanabria-Cabrera Marina Villanueva-Paz Lauryna Aukštikalnė Camilla Stephens Mercedes Robles-Díaz José M. Pinazo-Bandera Miren García-Cortes Isabel Conde German Soriano Fernando Bessone Nelia Hernandez Vinicius Nunes Raymundo Paraná M. Isabel Lucena Raúl J. Andrade Hao Niu Ismael Alvarez-Alvarez 10.1007/s00204-023-03630-0 2010-04-23 true springer.com springerlink.com https://doi.org/10.1007/s00204-023-03630-0 10.1007/s00204-023-03630-0 1432-0738 98 1 303 325 journal Archives of Toxicology The Author(s) 2010-04-23 true 10.1007/s00204-023-03630-0 noindex springer.com springerlink.com VoR uuid:a942cec7-331a-4758-b6bc-c220f7ad6c4c uuid:4cb13b95-64e3-4017-98b1-a943160dae9d default 1 converted uuid:e5de9556-88e1-46af-8df9-0a247ebd39ea converted to PDF/A-2b pdfToolbox 2023-12-21T16:42:16+05:30 converted uuid:015c4ce0-99ba-4d68-b828-fe5fc7cd3881 converted to PDF/A-2b pdfToolbox 2023-12-21T16:42:45+05:30 2 B M. 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