c68381c8c83a52a5a045016c8409c009 pmc_10804976.pdf afe830f455d92ee096adf7e526b52549bc49ee13 pmc_10804976.pdf 1ca387a5666d4d30f1ba0a20fbb117ff8e59f999d6a0dcd1d5e13903b13ba057 pmc_10804976.pdf Title: Interrelation between gut microbiota, SCFA, and fatty acid composition in pigs Subject: mSystems 2024.9:e01049-23 Keywords: gut microbiome, pig, lipid metabolism, prevotella, SCFA, functional prediction Author: Cristina Sebastià, Josep M. Folch, Maria Ballester, Jordi Estellé, Magí Passols, María Muñoz, Juan M. García-Casco, Ana I. Fernández, Anna Castelló, Armand Sánchez, Daniel Crespo-Piazuelo Creator: Antenna XSL House Formatter V7.3 MR2 Linux : 7.3.3.60933 (2023-04-21T14:08+09) Producer: Antenna House PDF Output Library 7.3.1866; modified using iText 4.2.0 by 1T3XT CreationDate: Wed Jan 17 08:56:58 2024 CET ModDate: Mon Jun 2 10:30:17 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 585 x 783 pts Page rot: 0 File size: 1104474 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KRRHVS+MyriadPro-Regular Type 1C Custom yes yes yes 74 0 KRRHVS+MyriadPro-Semibold Type 1C Custom yes yes yes 75 0 KRRHVS+MyriadPro-Regular Type 1C Custom yes yes yes 76 0 KRRHVS+MyriadPro-It Type 1C Custom yes yes yes 77 0 KRRHVS+MyriadPro-BoldSemiExt Type 1C Builtin yes yes yes 78 0 KRRHVS+MyriadPro-Light Type 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of gut microbiota Item: Title: Phenotypic analysis Item: Title: Phenotype and taxonomy association Item: Title: Functional prediction Item: Title: DISCUSSION Children: Item: Title: Conclusions Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 32 ImageHeight: 51 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 889 ImageHeight: 136 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1111 ImageHeight: 828 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 990 ImageHeight: 737 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 986 ImageHeight: 985 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FolchMaria BallesterJordi EstelléMagí PassolsMaría MuñozJuan M. García-CascoAna I. FernándezAnna CastellóArmand SánchezDaniel Crespo-PiazueloCristina SebastiàJosep M. FolchMaria BallesterJordi EstelléMagí PassolsMaría MuñozJuan M. García-CascoAna I. FernándezAnna CastellóArmand SánchezDaniel Crespo-PiazueloAmerican Society for MicrobiologyCopyright © 2023 Sebastià et al.This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.20232023The gut microbiota is a key player in the host metabolism. Some bacteria are able to ferment non-digestible compounds and produce short-chain fatty acids that the host can later transform and accumulate in tissue. In this study, we aimed to better understand the relationships between the microorganisms and the short-chain fatty acid composition of the rectal content, including the possible linkage with the fatty acid composition in backfat and muscle of the pig. We studied a Duroc × Iberian crossbred population, and we found significant correlations between different bacterial and archaeal genera and the fatty acid profile. The abundance of n-butyric acid in the rectal content was positively associated with Prevotella spp. and negatively associated with Akkermansia spp., while conversely, the abundance of acetic acid was negatively and positively associated with the levels of Prevotella spp. and Akkermansia spp., respectively. The most abundant genus, Rikenellaceae RC9 gut group, had a positive correlation with palmitic acid in muscle and negative correlations with stearic acid in backfat and oleic acid in muscle. These results suggest the possible role of Prevotella spp. and Akkermansia spp. as biomarkers for acetic and n-butyric acids, and the relationship of Rikenellaceae RC9 gut group with the lipid metabolism, building up the potential, although indirect, role of the microbiota in the modification of the backfat and muscle fatty acid composition of the host.20231003202311062379-5077uuid:ef4e68ab-a330-4048-b9a5-b89bb9b0c486uuid:3ad26082-08ea-47fc-9053-d4d1b7bf2b7b Antenna House PDF Output Library 7.3.1866; modified using iText 4.2.0 by 1T3XT Antenna XSL House Formatter V7.3 MR2 Linux : 7.3.3.60933 (2023-04-21T14:08+09) 2024-01-17T13:26:58+05:30 2025-06-02T01:30:17-07:00 2025-06-02T01:30:17-07:00 489dc4c0-fab4-4557-984e-3fd2dd831743 1 Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Contents: CHECK_FOR_UPDATE_LOGO Rect: 505, 701, 544, 742 LastModified: D:20240117132658+05'30' Flags: Print Annotation: Subtype: Link Contents: 10.1128/msystems.01049-23 Rect: 448, 23, 534, 32 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