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Association of magnetic resonance imaging phenotypes and serum biomarker levels with treatment response and long-­term disease outcomes in multiple sclerosis patients Children: Item: Title: Abstract Item: Title: INTRODUCTION Item: Title: METHODS Children: Item: Title: Patients Item: Title: Baseline MRI phenotypes Item: Title: Quantification of serum biomarker levels Item: Title: Disease outcomes Item: Title: Statistical analysis Item: Title: RESULTS Children: Item: Title: Demographic and clinical characteristics of RRMS patients at baseline Item: Title: Serum NfL levels are associated with the high inflammation phenotype and GFAP levels with the high neurodegeneration phenotype Item: Title: High inflammation phenotype and high serum NfL levels are associated with the response to IFNβ treatment Item: Title: Radiological phenotypes, but not serum biomarker levels, are associated with long-­term prognosis Item: Title: DISCUSSION Item: Title: AUTHOR CONTRIBUTIONS Item: Title: CONFLICT OF 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